Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease

Pacifico, Lucia; Andreoli, G; D'Avanzo, M; Mitri, Delia De; Pierimarchi, Pasquale

doi:10.3748/wjg.v24.i19.2073

Cited by 19 publications

(15 citation statements)

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“…Spearman's correlation analysis showed that there was a significant negative correlation between 25(OH)D and the degree of patients in the NAFLD group, suggesting that 25(OH)D can be used as a monitoring indicator for the severity of NAFLD. Pacifico et al (26) found that the incidence of vitamin D deficiency was significantly higher in patients with cirrhosis than in patients without cirrhosis (86.3 vs. 49.0%, P=0.0001). In the liver function score, the level of vitamin D in Child C group was significantly lower than that in Child A group.…”

Section: Discussionmentioning

confidence: 97%

Correlation between serum 25‑OH vitamin D expression and non‑alcoholic fatty liver disease

et al. 2020

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This study investigated changes in the level of serum 25(OH)D] in patients with non-alcoholic fatty liver disease (NAFLD) and the correlation between the severity of NAFLD and 25(OH)D. A retrospective analysis was performed on 385 NAFLD patients (NAFLD group) admitted to the Zhongshan Hospital and 347 healthy people with physical examination (control group). The height and weight of all subjects were measured, and BMI was calculated. Fasting venous blood was extracted for the determination of blood glucose, blood lipid and 25(OH)D. The indicator levels of patients in the two groups were compared and analyzed. Spearman's correlation analysis was used to investigate the correlation between the severity of NAFLD and the level of 25(OH)D. The levels of BMI, FPG, FPI, HbA1c, TG, TC and LDL-C of patients in the NAFLD group were significantly higher than those in control group (P<0.05). The level of 25(OH)D in the NAFLD group was lower than that in control group (P<0.05). There was a significant negative correlation between 25(OH)D and the severity of patients in the NAFLD group (r=-0.868, P<0.001). BMI, FPG, FPI, HbA1c, TG, TC and LDL-C were independent risk factors for the low level of 25(OH)D (P<0.05). Lowly expressed in the serum of NAFLD patients, 25(OH)D has a significant negative correlation with the severity of NAFLD, which is of guiding significance for the prevention and treatment. 25(OH)D is a novel biomarker for NAFLD diagnosis and a potential drug target. Patients and methodsPatient data. A retrospective analysis was performed on 385 NAFLD patients admitted to the Zhongshan Hospital Affiliated to Xiamen University (Xiamen, China) from January 2015 to December 2017 and 347 healthy people with physical examination. There were 385 NAFLD patients in the NAFLD group, including 237 males and 148 females, aged

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Section: Discussionmentioning

confidence: 97%

Correlation between serum 25‑OH vitamin D expression and non‑alcoholic fatty liver disease

et al. 2020

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“…The most commonly expressed miRNA in the human liver is miR-122, which is involved in NAFLD and is associated with a high risk of developing HCC [154]. Epigenetics has presented potential diagnostic, prognostic, and therapeutic targets [155,156].…”

Section: Genetical Evaluation and Multi-omics Profiles Of Nafldmentioning

confidence: 99%

Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical, Biochemical, and Scoring Methods in the Assessment of NAFLD

Kupčová

Fedelešová

Bulas

et al. 2019

IJERPH

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Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. It represents a range of disorders, including simple steatosis, nonalcoholic steatohepatitis (NASH), and liver cirrhosis, and its prevalence continues to rise. In some cases, hepatocellular carcinoma (HCC) may develop. The develop;ment of non-invasive diagnostic and screening tools is needed, in order to reduce the frequency of liver biopsies. The most promising methods are those able to exclude advanced fibrosis and quantify steatosis. In this study, new perspective markers for inflammation, oxidative stress, apoptosis, and fibrogenesis; emerging scoring models for detecting hepatic steatosis and fibrosis; and new genetic, epigenetic, and multiomic studies are discussed. As isolated biochemical parameters are not specific or sensitive enough to predict the presence of NASH and fibrosis, there is a tendency to use various markers and combine them into mathematical algorithms. Several predictive models and scoring systems have been developed. Current data suggests that panels of markers (NAFLD fibrosis score, Fib-4 score, BARD score, and others) are useful diagnostic modalities to minimize the number of liver biopsies. The review unveils pathophysiological aspects related to new trends in current non-invasive biochemical, genetic, and scoring methods, and provides insight into their diagnostic accuracies and suitability in clinical practice.

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“… 9 Another study shows that there is a correlation between serum osteoprotegerin levels in patients having hepatitis C virus infection of prolonged duration with many cardiovascular complications. 10 …”

Section: Introductionmentioning

confidence: 99%

Association of serum osteoprotegerin with severity of chronic liver disease in female patients: A potential biomarker

Tariq

Hussain

et al. 2020

Pak J Med Sci

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Objective: To determine the association of serum osteoprotegerin (OPG) with the severity of chronic liver disease in female patients. Methods: This case-control study was conducted in Madina Teaching Hospital from 2019-2020.An institutional review board of University Medical and Dental College, The University of Faisalabad gave the approval to conduct the study. Only female patients of age group 40 to 60 years having CLD were included in this study. Total 80 participants were enrolled after fulfilling the inclusion and exclusion criteria. Serum OPG levels were measured by enzyme linked immunosorbant assay (ELISA) supplied by ELAB Sciences, USA. The severity of disease was assessed by Child-Pugh classification. Results: OPG levels were significantly different between the three Child-Pugh classes. OPG levels were significantly high in class C indicating increased level of this cytokine in CLD as compared to class A (p = <0.05). There was a positive association of OPG with splenomegaly (OR = 2.10, p = <0.001), hepatomegaly (OR = 4.41, (p = < 0.05), skin pigmentation (OR = 2.06, p = <0.05), malena (OR = 1.87, p = <0.05) and prolonged bleeding (OR = 1.86, p = <0.05). Conclusion: The levels of serum Osteoprotegerin is increased in severe form of chronic liver disease (Class C) of Child-Pughs classification as compared to mild (Class A) and moderate (Class B) forms of Child-Pughs classification. doi: https://doi.org/10.12669/pjms.36.6.2678 How to cite this:Tariq S, Tariq S, Hussain S, Baig M. Association of serum osteoprotegerin with severity of chronic liver disease in female patients: A potential biomarker. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2678 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease

Cited by 19 publications

References 88 publications

Correlation between serum 25‑OH vitamin D expression and non‑alcoholic fatty liver disease

Correlation between serum 25‑OH vitamin D expression and non‑alcoholic fatty liver disease

Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical, Biochemical, and Scoring Methods in the Assessment of NAFLD

Association of serum osteoprotegerin with severity of chronic liver disease in female patients: A potential biomarker

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