Role of oxidant–antioxidant imbalance in the pathogenesis of chronic obstructive pulmonary disease

El‐Masry, Samir; Al-Azzawi, Mahmood A.; Ghoneim, Adel H.; Nasr, Mohamed Y.; Abozaid, Mohamed

doi:10.1016/j.ejcdt.2015.06.001

Cited by 20 publications

(25 citation statements)

References 45 publications

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“…Stressful conditions lead to excessive production of free radicals which cause an imbalance in the oxidant/ antioxidant system [9] . Testicular tissues are rich in polyunsaturated fatty acid content and poor in antioxidant defense so, they are prone to be attacked by reactive oxygen species (ROS) which are capable of oxidizing proteins, lipids, and deoxyribonucleic acid (DNA) leading to cellular damage [10] .…”

Section: Introductionmentioning

confidence: 99%

The effect of chronic stress on the testis of adult albino Rats and the possible protective effect of astaxanthin supplementation (Histological, immunohistochemical and biochemical studies)

Mohammed

elfadeel

Abdel-aziz

et al. 2019

Journal of Medical Histology

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Background and Objectives: Stress can disrupt homeostasic balance within the organisms. Chronic stress can have damaging effects on the whole organism. The present study aimed to throw more light on themolecular,immunological and histological alterations in adult albino rat's testis subjected to chronic stress and to demonstrate whether the potential chronic stress-induced testicular alterations could be ameliorated by astaxanthin or not. Materials and Methods: Forty healthy adult male albino rats were used in this study, they were assigned as 3 main groups: Group I (Control group) which are subdivided into two equal groups, Group II (stress group) rats were restrained for 1 h and after 4 hs they are forced to swim for 15 minutes every day for 6 months, and Group III (protective group) rats were subjected to stressors as previous group in concomitant with daily administration of astaxanthin (25mg/kg b.w.) dissolved in 1ml normal saline in a single daily doseorally in a single daily dose. Blood samples and testicular tissues were collected and assayed for histological, immunohistochemical and biochemical changes. Results: The results of the present study demon¬strated thatthere were degenerative changes in spermatogenic and Sertoli cells of stress group and were associated with statistical significant reduction in height of germinal epithelium, Ki-67 and vimentinimmunoexpression.These changes were observed to be reduced in astaxanthin protected group.Also,there was a decrease in serum testosterone levels in stress group, which were normalized after astaxanthin administration. Also, stress significantly increased the serum levels of malondialdehyde, and decreased levels of total antioxidant capacity TAC. Conclusions: This study concluded that astaxanthin has beneficial protective effects against the deleterious effects of chronic stress on the testis. Therefore, it may be a suitable nutrional supplement in alleviating some negative aspects of chronic stress effects on testis.

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Section: Introductionmentioning

confidence: 99%

The effect of chronic stress on the testis of adult albino Rats and the possible protective effect of astaxanthin supplementation (Histological, immunohistochemical and biochemical studies)

Mohammed

elfadeel

Abdel-aziz

et al. 2019

Journal of Medical Histology

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“…40 In our study, moderate to strong positive correlations were found between both total cholesterol and triglycerides and O 2 As a rich source of active oxidants, cigarette smoke may cause an imbalance in the endogenous antioxidant defences that are associated with increased production of free ROS. 42 Vitamin C, a strong antioxidant, has a hydrophilic nature and a unique structure that makes it an excellent electron donor for scavenging free RONS. 7 However, vitamin E has a lipophilic nature that enables it to pass through the cell membrane to scavenge free reactive species.…”

Section: Discussionmentioning

confidence: 99%

Comparative assessment of individual RONS in serum of smokers compared with non-smokers and their correlation with the lipid profile and antioxidant status

Khojah

Ahmed

2019

J Int Med Res

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Objective Cigarette smoking generates free radicals, such as reactive oxygen and nitrogen species (RONS) that contribute to many diseases. The aim of this study was to compare the levels of individual RONS in serum from smokers and non-smokers, and to examine their impact on lipid profiles and the endogenous antioxidant status, which is represented by vitamins C and E. Methods Ninety-four healthy Egyptian volunteers (48 smokers and 46 non-smokers) were enrolled. Blood samples were collected and analysed for common haematological tests, lipid profiles, and serum antioxidants. Six reactive oxygen species and three reactive nitrogen species were measured. Results A significant increase in radical levels was observed, as well as significant increases in haemoglobin (Hb), haematocrit, platelet count, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol in smokers compared with non-smokers. In contrast, high-density lipoprotein cholesterol was significantly reduced in smokers compared with non-smokers. A moderate negative correlation was found between serum levels of vitamins C and E and O2–•, HO•, H2O2, NO•, and ONO•, reflecting a negative impact of elevated RONS levels on the endogenous antioxidant status. Conclusion These results may increase our understanding of the pathological role of smoking in several diseases.

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“…The latter showed that the rGSH concentrations were significantly lower in COPD patients than controls (SMD = −3.04, 95% CI = −4.42 to −1.67; p < 0.001). Despite the potentially distortive effects of two studies [45,47], a sensitivity analysis performed by recalculating the confidence interval of the pooled effect size after eliminating each study at a time showed no substantial modification of the effect size, which ranged between −2.10 and −3.37 (Figure 3). The funnel plot in Figure 4 confirms the distortive effects of the two above-mentioned studies.…”

Section: Blood Reduced Gsh (Rgsh) and Copdmentioning

confidence: 99%

Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease

et al. 2020

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The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled reduced GSH concentrations were significantly lower in patients with COPD than controls (SMD = −3.04, 95% CI = −4.42 to −1.67; p < 0.001). By contrast, the pooled total GSH concentrations were significantly higher in patients with COPD than controls (SMD = 0.42, 95% CI = 0.11 to 0.73; p = 0.009). Our meta-analysis showed that the blood concentrations of reduced GSH, even in the presence of higher total GSH concentrations, were significantly lower in patients with COPD when compared to healthy controls. This suggests that an impaired antioxidant defense system plays an important role in the pathogenesis of COPD.

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Role of oxidant–antioxidant imbalance in the pathogenesis of chronic obstructive pulmonary disease

Cited by 20 publications

References 45 publications

The effect of chronic stress on the testis of adult albino Rats and the possible protective effect of astaxanthin supplementation (Histological, immunohistochemical and biochemical studies)

The effect of chronic stress on the testis of adult albino Rats and the possible protective effect of astaxanthin supplementation (Histological, immunohistochemical and biochemical studies)

Comparative assessment of individual RONS in serum of smokers compared with non-smokers and their correlation with the lipid profile and antioxidant status

Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease

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