Role of oxidative stress and low-grade inflammation in letrozole-induced polycystic ovary syndrome in the rat

Pandey, Vivek; Singh, Anusha; Singh, Ajit; Krishna, Amitabh; Pandey, Uma; Tripathi, Yamini B.

doi:10.1016/j.repbio.2015.12.005

Cited by 45 publications

(31 citation statements)

References 34 publications

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“…[22], thus the activities of antioxidant enzymes are a re ection of the antioxidative function of animal. The supplementation of exogenous antioxidants or utilizing plant source rich in antioxidants could be effective to prevent oxidative stress and improve animal health [21,23]. It was reported mulberry leaves could be a source of natural antioxidants to combat oxidative stress in livestock production due to its scavenging of free radicals in animal feed [7].…”

Section: Discussionmentioning

confidence: 99%

Mining Novel Specific Rumen Bacteria to Enhance the Bioactive Function of Mulberry Leaf in Promoting Host Antioxidant Activity and Immunomodulatory

Wang¹,

Luo²

2020

Preprint

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Background: Rumen is a natural fermentation system and the microorganisms inside can effectively utilize plant bioresource and interact with host metabolism. Here, analysis of rumen microbiome, together with animal performance and serum metabolism in a lamb model were performed to identify the potential use of mulberry leaf silage (MS) to replace alfalfa silage (AS) as a new functional feed resource and to mining the novel specific mulberry leaf associated rumen bacteria interact with host metabolism. Results: The lambs fed with MS diet showed improved antioxidant capacity and immune function compared to those fed AS diet. The MS diet significantly altered rumen microbiota α- and β-diversity and taxonomic composition. Microbial analysis revealed that Bifidobacterium, Lactobacillus and Schwartzia were enhanced, and Ruminococcaceae UCG-010 and Lachnospiraceae_XPB1014_group were down-regulated in the rumen of MS group. A strong association was also found between these rumen microbial taxa and host antioxidant capacity and immunomodulatory. Conclusion: These findings indicated that mulberry leaf silage can be a high-quality feed source or bioactive pharmaceutical that is responsible for ruminants health benefits by modifying the rumen microbial community with potentially enhanced probiotics and inhibited biohydrogenation and methane emission.

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Section: Discussionmentioning

confidence: 99%

Mining Novel Specific Rumen Bacteria to Enhance the Bioactive Function of Mulberry Leaf in Promoting Host Antioxidant Activity and Immunomodulatory

Wang¹,

Luo²

2020

Preprint

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“…Much more studies showed that the concentration levels of OS markers in PCOS higher than normal, such as lipid peroxidation (LPO) [66]. A study reported that the advanced oxidation protein products in women with PCOS were higher than that in health women with the same age and body mass index (BMI), while the total antioxidant levels were lower [67].…”

Section: Oxidative Stressmentioning

confidence: 99%

“…A study reported that the advanced oxidation protein products in women with PCOS were higher than that in health women with the same age and body mass index (BMI), while the total antioxidant levels were lower [67]. Previous studies suggested that OS is associated with obesity of PCOS patients, but recent studies have found elevated OS markers levels in lean PCOS patients [66].…”

Section: Oxidative Stressmentioning

confidence: 99%

Diagnosis, Pathogenesis and Management of Polycystic Ovary Syndrome

Wang¹

2017

Testes and Ovaries - Functional and Clinical Differences and Similarities

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Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine diseases occurs among women of childbearing age, which is affected by many factors, but its precise pathophysiology has not yet been determined. The heterogeneous of PCOS is reflected in its complex endocrine dysfunction of the hypothalamic-pituitarygonadal axis (HPG axis) and its multiple clinical features, such as obesity, insulin resistance, hyperandrogenism and anovulation. Meanwhile, women with PCOS also have an increased risk of major cardiovascular events, most notably type 2 diabetes, cardiovascular disease and atherosclerosis. So far, many therapies are available for improving reproductive and metabolic abnormalities in PCOS patients, in which lifestyle modification and insulin-sensitizing agents are more effective management strategies.

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“…increased LH/Follicle stimulating hormone (FSH) ratio, and increase in amplitude and frequency of pulsatile LH secretion 3,4 . Recent study shows that increased insulin resistance and compensatory hyper-insulinemia play a key role in the pathogenesis of PCOS 5 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2018

IJPSR

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Introduction: There are numerous animal models available for polycystic ovary syndrome (PCOS), a fully convincing model for PCOS reflecting all pathologic condition of PCOS seen in humans is not available due to difficulties in inducing all pathologies in rat models. If so, it will help to test drug to treat PCOS. The main goal of this study is to create a new model to reflect all pathologic conditions of PCOS seen in humans using non-steroidal aromatase inhibitor letrozole and fructose in rats. Methods: Twelve rats were divided into two groups containing 6 rats each. Vehicle control group rats received 1% aqueous solution of carboxmethlycellulose (CMC) once daily orally for 28 days and PCOS group was administered letrozole at a concentration of 1 mg/kg dissolved in 1% CMC p.o. once daily for 28 days. Along with these rats were allowed free access of 10% fructose solution daily. During experimental period, vaginal smears were collected daily for estrus cycle determination. Rats were sacrificed and blood sample were collected for hormonal and other biochemical assays. Ovaries were removed to proceed with histolopathological study. Results: When compared to vehicle control group, ovaries from PCOS group showed high incidence of ovarian cyst with incomplete luteinization and decreased number of corpus lutea. Although serum estradiol and progesterone levels were reduced, testosterone levels were elevated, as were levels of luteinizing hormone (LH). Serum follicle-stimulating hormone (FSH) levels were markedly increased in the PCOS group. The PCOS group rats showed significant increase in insulin resistance with compensatory significant hyperinsulinemia than the vehicle control group. Conclusions: Our study was completely fulfilling and convincing as in human PCOS, this rat model is fully convincing for studying PCOS and in several ways, it is similar to the human PCOS.

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Role of oxidative stress and low-grade inflammation in letrozole-induced polycystic ovary syndrome in the rat

Cited by 45 publications

References 34 publications

Mining Novel Specific Rumen Bacteria to Enhance the Bioactive Function of Mulberry Leaf in Promoting Host Antioxidant Activity and Immunomodulatory

Mining Novel Specific Rumen Bacteria to Enhance the Bioactive Function of Mulberry Leaf in Promoting Host Antioxidant Activity and Immunomodulatory

Diagnosis, Pathogenesis and Management of Polycystic Ovary Syndrome

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