Role of Physical Activity and Exercise in Treating Patients with Overweight and Obesity

Jakicic, John M.; Rogers, Renee J.; Davis, Kelliann K.; Collins, Katherine A.

doi:10.1373/clinchem.2017.272443

Cited by 123 publications

(97 citation statements)

References 72 publications

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“…Physical activity is an important non-pharmacological intervention for managing chronic lifestyle-related diseases, such as obesity and diabetes. While the beneficial effects of exercise are well documented and evidence indicates that regular exercise is a viable, cost effective but underused treatment [11], the related molecular mechanisms are not yet fully understood [12,13]. Reports addressing circulating concentrations of EPHX2 and its metabolites in response to exercise in humans are scarce.…”

Section: Introductionmentioning

confidence: 99%

Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity

Khadir

Kavalakatt

Madhu

et al. 2020

IJMS

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Epoxide hydrolase 2 (EPHX2) is an emerging therapeutic target in several immunometabolic disorders. EPHX2 metabolizes anti-inflammatory epoxyeicosatrienoic acids into pro-inflammatory diols. The contribution of EPHX2 activity to human obesity remains unexplored. We compared the expression of EPHX2 between lean and obese humans (n = 20 each) in subcutaneous adipose tissue (SAT) and peripheral blood mononuclear cells (PBMCs) using RT-PCR, Western Blot analysis, immunohistochemistry, and confocal microscopy before and after a 3-month physical activity regimen. We also assessed EPHX2 levels during preadipocyte differentiation in humans and mice. EPHX2 mRNA and protein expression were significantly elevated in obese subjects, with concomitant elevated endoplasmic reticulum (ER) stress components (the 78-kDa glucose-regulated protein; GRP78, and the Activating transcription factor 6; ATF6) and inflammatory markers (Tumor necrosis factor-α; TNFα, and Interleukin 6; IL6) as compared to controls (p < 0.05). EPHX2 mRNA levels strongly correlated with adiposity markers. In obese individuals, physical activity attenuated EPHX2 expression levels in both the SAT and PBMCs, with a parallel decrease in ER stress and inflammation markers. EPHX2 expression was also elevated during differentiation of both human primary and 3T3-L1 mouse preadipocytes. Mediators of cellular stress (palmitate, homocysteine, and macrophage culture medium) also increased EPHX2 expression in 3T3-L1 preadipocytes. Our findings suggest that EPHX2 upregulation is linked to ER stress in adiposity and that physical activity may attenuate metabolic stress by reducing EPHX2 expression.

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Section: Introductionmentioning

confidence: 99%

Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity

Khadir

Kavalakatt

Madhu

et al. 2020

IJMS

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“…Finally, participants were least willing, on average, to pursue physical activity targets. Given the importance of physical activity for weight management (Jakicic, Rogers, Davis, & Collins, ), additional design efforts may be needed to inform how to engage users in these goals.…”

Section: Discussionmentioning

confidence: 99%

Past, current, and future willingness to engage with treatment targets: Applying user‐centered design to inform the design of a mobile behavioral intervention

Weinheimer

Chang

Neubert

et al. 2020

Intl J Eating Disorders

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Objective: User-centered design can improve engagement with and the potential efficacy of behavioral interventions, but is underutilized in health care. This work demonstrates how design methodologies can inform the design of a mobile behavioral intervention for binge eating and obesity.Method: A needs assessment was conducted with end-users (N = 22 adults with obesity and recurrent binge eating [≥12 episodes in 3 months] who were interested in losing weight and addressing binge eating), which included assessing participants' past/current and future willingness to engage with 20 treatment targets for managing binge eating and weight. Targets focused on improving dietary intake, increasing physical activity, and reducing overvaluation of weight and/or shape, unhealthy weight control practices, and negative affect. Results:Participants' past and current use of targets varied. For all targets except those addressing unhealthy weight control practices, on average, participants had increasing levels of willingness to try targets. Among participants not currently using a target, at least some were willing to use every target again.Discussion: Findings inform ways to personalize how users begin treatment. Furthermore, this study exemplifies how user-centered design can inform ways to ensure that digital interventions are designed to meet end-users' needs to improve engagement and clinical impact.

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“…Recently obesity and overweight prevalence has increased in many industrial countries, making it depressing for many populations. It is reported that more particularly in developing countries along with the developing level of welfare and domestic income, reasons such as changes in nutrition habits of individuals and insufficient physical activities increase the level of obesity [4] [40] [41] [42]. This study backs up this report as it shows that subjects have healthy lifestyle behaviors with low rates of 3.4% for regular physical activity, 26.0% for health responsibility and 38.4% for regular nutrition habits ( Table 5).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Obesity Prevalence and Physical Activity and Health Responsibility in Elazig City Population

Arslan¹,

Cakaroglu²

2018

Health

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Objective: This paper examines obesity prevalence, physical activity and health responsibility in Elazig. Material and Method: The study was conducted on 2905 men (20 -69) and 2131 women (20 -69), with an average of (40.93 ± 9.14) chosen randomly. Health-Promoting Lifestyle Profile was obtained via Healthy Lifestyle Behaviors Scale by Walker & Pender (1987). In this paper, three sub-evaluation dimensions of HPLP-II, health responsibility, exercise and nutritional behavior were used. Body compositions were obtained with bioelectrical impedance and Waist Circumference (WC) Central obesity by measuring waist circumference. Statistical analyses were assessed in SPSS 22.0. With Chi square, ANOVA, linear and logistic regression analyses, significance levels were p < 0.05 and 0.001. Result: Obesity prevalence was 38.8%, 37.9% and 38.4% and rate of WC abdominal prevalence was 38.2%, 29.3% and 33.0% in men, women and general population respectively. Obesity prevalence was more in men (p < 0.001). Combined prevalence rate of overweight and obese individuals was 70.1%. Obesity prevalence increases after 35 and reaches high (55% -80%), and correlation rates were found significant (p < 0.001). Conclusion: Obesity prevalence and abdominal obesity were critical health issues among adults. Individuals couldn't develop conscious attitudes towards physical activity, nutrition and health responsibility and overcome obesity. Social strategies should be developed to reduce obesity risk factors.

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Role of Physical Activity and Exercise in Treating Patients with Overweight and Obesity

Abstract: The literature supports the inclusion of physical activity as an important lifestyle behavior for regulating body weight. There are multiple intervention approaches that may be effective for enhancing physical activity engagement within the context of weight control.

Cited by 123 publications

References 72 publications

Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity

Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity

Past, current, and future willingness to engage with treatment targets: Applying user‐centered design to inform the design of a mobile behavioral intervention

Evaluation of Obesity Prevalence and Physical Activity and Health Responsibility in Elazig City Population

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