Role of plasma asymmetric dimethyl-L-arginine levels in detection of pulmonary hypertension in children with CHD

Farag, Marwa; Amrousy, Doaa El; El-Serogy, Hesham; Zoair, Amr

doi:10.1017/s1047951118001026

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease (CHD) [1]. PAH increases the probability for a variety of arrhythmias to occur through changing the homogeneity of ventricular repolarization and atrial conduction by several methods such as the modulation of autonomic activity, delayed cardiac repolarization, and right ventricular myocardial ischemia [2], [3].…”

Section: Introductionmentioning

confidence: 99%

Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias

Saleh

Shabana

Amrousy

et al. 2019

Journal of the Saudi Heart Association

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ObjectivesTo evaluate P-wave dispersion (PWD) and QT dispersion (QTd) in children with congenital heart disease and pulmonary arterial hypertension (PAH-CHD) and to investigate the predictive value of both PWD and QTd for prediction of arrhythmias in such children.Materials and methodsWe included 40 children with PAH-CHD as Group I. Forty other children with CHD and no PAH were included as Group II. Forty healthy children of matched age and sex served as a Control group. Electrocardiography was performed to determine PWD and QTd. Furthermore, 24-hour Holter monitoring was performed to detect the presence of arrhythmias. Echocardiographic evaluation was also performed.ResultsQTd and PWD were significantly higher in Group I than in Group II and Control group. A significant positive correlation was present between both QTd and PWD and mean pulmonary artery pressure, right ventricular diameter, pulmonary vascular resistance (PVR), and PVR to systemic vascular resistance ratio. QTd showed 93% sensitivity, 80% specificity, and 85% accuracy for prediction of occurrence of arrhythmias in patients with PAH-CHD at a cutoff point of 61 ms, whereas PWD showed 87% sensitivity, 80% specificity, and 85% accuracy for prediction of arrhythmias at a cutoff point of 32.5 ms in such patients. Logistic regression analysis showed that both QTd and PWD were good predictors for the occurrence of arrhythmias in children with PAH-CHD (p = 0.003 and p = 0.01, respectively).ConclusionsPWD and QTd were good predictors for the occurrence of various arrhythmias in children with PAH-CHD.

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Section: Introductionmentioning

confidence: 99%

Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias

Saleh

Shabana

Amrousy

et al. 2019

Journal of the Saudi Heart Association

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“…The study stated that the results of ADMA levels were significantly lower in patients receiving sildenafil compared to the control group. 31 Meanwhile, according to research by Mass R (2005), the administration of ACE inhibitors and ARBs can reduce plasma ADMA levels by 12-20%. 32 In this study, the duration of administration of ACE inhibitors and sildenafil was not previously included in the research data on all study subjects in both groups.…”

Section: Discussionmentioning

confidence: 99%

Effect of Pomegranate Extract On N-Terminal Pro Brain Natriuretic Peptide and Asymmetric Dimetylarginine Levels in Children with Pulmonary Artery Hypertension in Acyanotic Congenital Heart Disease

Noer¹,

Rahman²,

Utomo³

2023

Pharmacogn J.

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Background: Pulmonary arterial hypertension (PAH) is one of the complications due to acyanotic congenital heart disease. New treatment approach using natural ingredients from plants has been demonstrated in vitro to prevent and improve vascular remodeling in PAH. Objective: This study aimed to analyze the effect of pomegranate extract on N-terminal pro brain natriuretic peptide (NT pro BNP) and asymmetric dimethylarginine (ADMA) levels in children with PAH in acyanotic CHD. Method: This study is a double-blind, quasi-experimental text with pre-test, post-test, and control group approach to children aged one month to 10 years old in Outpatient

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“…One of the most important types of PH in children is pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) [ 5 ]. PAH-CHD is usually the result of a large systemic to pulmonary shunt, and often leads to right ventricular failure and early death [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Platelet Activation Markers in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

et al. 2022

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The study aimed to evaluate mean platelet volume (MPV), platelet distribution width (PDW), and platecrit in children with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD), to assess the predictive value of these platelet activation markers for adverse outcomes, and to correlate their levels with various data in these patients. This prospective cohort study included 60 children with PAH-CHD as group I and 60 children with CHD and no PAH as group II. Another 60 healthy children of matched age and sex served as the control group. All included children were evaluated by echocardiography. MPV, PDW, and platecrit were also measured using an automated blood counter. All patients were followed up for death or readmission for 6 months. MPV, PDW, and platecrit were significantly higher in group I compared to group II and the control group and they correlated well with increasing severity of PAH. MPV, PDW, and platecrit positively correlated with right ventricular diameter and mean pulmonary artery pressure, however they correlated negatively with right ventricular systolic and diastolic function. The best cut-off of platelet activation markers levels to predict poor prognosis in group I was > 11.2 FL with 75% sensitivity and 96.6% specificity for MPV, > 12.7 FL with 75% sensitivity and 61.5% specificity for PDW, and > 0.505% with 75% sensitivity and 93.2% specificity for platecrit. MPV, PDW, and platecrit were elevated in children with PAH-CHD and found to be good predictive markers for poor prognosis in these children.

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Role of plasma asymmetric dimethyl-L-arginine levels in detection of pulmonary hypertension in children with CHD

Abstract: Asymmetric dimethyl-L-arginine level has a good diagnostic and prognostic value as a biomarker in children with pulmonary hypertension-CHD and can be used for following up patients with pulmonary hypertension and predicting response to treatment.

Cited by 7 publications

References 14 publications

Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias

Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias

Effect of Pomegranate Extract On N-Terminal Pro Brain Natriuretic Peptide and Asymmetric Dimetylarginine Levels in Children with Pulmonary Artery Hypertension in Acyanotic Congenital Heart Disease

Platelet Activation Markers in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

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