Role of plasma high mobility group box-1 in disseminated intravascular coagulation with leukemia

Wang, Manzhi; Mei, Heng; Kou, Haiming; Deng, Jun; Wang, Huafang; Guo, Tao; Hu, Yu

doi:10.1016/j.thromres.2015.05.030

Cited by 4 publications

(8 citation statements)

References 40 publications

(39 reference statements)

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“…Clinically, serum HMGB1 and histone H3 levels in patients with sepsis and acute leukemia were elevated in non-survivors [ 9 – 13 ]. In addition, the elevation of serum HMGB1 and histone H3 levels was found in patients with DIC and in patients with organs failure [ 10 , 12 , 13 ]. Regarding laboratory findings, serum HMGB1 and histone H3 levels were correlated with ISTH DIC scores [ 10 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

et al. 2022

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Background We compared the prognostic value of serum high mobility group box 1 protein (HMGB1) and histone H3 levels with the International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC) scores for 28-day in-hospital mortality in patients with DIC caused by various underlying diseases. Methods We conducted a multicenter prospective cohort study including two hematology departments, four emergency departments, and one general medicine department in Japan, between August 2017 and July 2021. We included patients diagnosed with DIC by the ISTH DIC scoring system. Results Overall, 104 patients were included: 50 with hematopoietic disorders, 41 with infections, and 13 with the other diseases. The 28-day in-hospital mortality rate was 21%. The receiver operator characteristic (ROC) curve showed that a DIC score of 6 points, serum HMGB1 level of 8 ng/mL, and serum histone H3 level of 2 ng/mL were the optimal cutoff points. The odds ratios of more than these optimal cutoff points of the DIC score, serum HMGB1, and histone H3 levels were 1.58 (95% confidence interval [CI]: 0.60 to 4.17, p = 0.36), 5.47 (95% CI: 1.70 to 17.6, p = 0.004), and 9.07 (95% CI: 2.00 to 41.3, p = 0.004), respectively. The area under the ROC curve of HMGB1 (0.74, 95% CI: 0.63 to 0.85) was better than that of the ISTH DIC scores (0.55, 95% CI: 0.43 to 0.67, p = 0.03), whereas that of histone H3 was not (0.71, 95% CI: 0.60 to 0.82, p = 0.07). Calibration and net reclassification plots of HMGB1 identified some high-risk patients, whereas the ISTH DIC scores and histone H3 did not. The category-free net reclassification improvement of HMGB1 was 0.45 (95% CI: 0.01 to 0.90, p = 0.04) and that of histone H3 was 0.37 (95% CI: − 0.05 to 0.78, p = 0.08). Conclusions Serum HMGB1 levels have a prognostic value for mortality in patients with DIC. This finding may help physicians develop treatment strategies.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

et al. 2022

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“…The Role of HMGB1 in Disseminated Intravascular Coagulation Disseminated intravascular coagulation (DIC) is a clinical syndrome characterized by the activation of the coagulation system. Increasing evidence supports the role of HMGB1 in DIC [60,61]. Serum HMGB1 level was higher in patients with DIC when compared to controls [61].…”

Section: The Role Of Hmgb1 In Strokementioning

confidence: 91%

“…However, patients with organ failure and nonsurvivors exhibit the highest HMGB1 levels among patients with DIC [61]. This suggests that elevated HMGB1 is directly associated with organ failure in DIC [60,61].…”

Section: The Role Of Hmgb1 In Strokementioning

confidence: 98%

Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease

et al. 2018

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High mobility group box 1 protein (HMGB1), a sterile inflammatory molecule and damage-associated molecular pattern (DAMP) released from various cells during stress has been implicated in inflammation. Several reports show that there is a direct relationship between inflammation and cardiovascular diseases (CVDs) such as thrombosis, hypertension, insulin resistance, preeclampsia, etc. Here, we intend to summarize the concept of the emerging link between HMGB1 and CVDs. Furthermore, we will discuss the possible therapeutic strategies that target HMGB1 for the treatment of different CVDs.

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“…Besides, patients with organ failure and nonsurvivors exhibited the highest HMGB-1 levels among patients with DIC [98]. This suggested that HMGB-1 level increased and was associated with organ failure in DIC [96,98]. Two recent studies reported the role of HMGB-1 in venous thrombosis.…”

Section: Figmentioning

confidence: 95%

“…Disseminated intravascular coagulation (DIC) is a clinical syndrome characterized by the activation of the coagulation system, and increasing evidence has supported the role [96]. Moreover, patients with higher HMGB-1 in hematological malignancies might be complicated by DIC [99].…”

Section: Figmentioning

confidence: 99%

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

Pei

et al. 2018

Cell Physiol Biochem

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High mobility group box-1 (HMGB-1), a typical damage-associated molecular pattern protein released from various cells, was first identified in 1973. It is usually stored in the nuclei of cells. Several modifications of HMGB-1 promote its translocation to the cytosol, and it is actively or passively released from cells. When outside of the cells, HMGB-1is crucial in inflammation. It exerts its biological functions via interaction with its receptors, including receptor for advanced glycation end products (RAGE) and Toll-like receptor 4(TLR4). A large number of studies showed a close link between inflammation and thrombosis. This review demonstrated the increased expression of HMGB-1 in thrombosis-related diseases, including coronary artery disease, stroke, peripheral arterial disease, disseminated intravascular coagulation, and venous thrombosis. Besides, it summarized the current understanding of the emerging link between HMGB-1 and thrombosis from three aspects: platelet, NETs, and coagulation and fibrinolysis factors. Finally, it explored the possible therapeutic strategies targeting HMGB-1 for treating thrombosis-related diseases.

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Role of plasma high mobility group box-1 in disseminated intravascular coagulation with leukemia

Cited by 4 publications

References 40 publications

Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

Sterile Inflammatory Role of High Mobility Group Box 1 Protein: Biological Functions and Involvement in Disease

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

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