Role of plasticizer in membrane coated extended release oral drug delivery system

Khatri, Pinak; Desai, Dipen; Shelke, Namdev B.; Minko, Tamara

doi:10.1016/j.jddst.2017.12.020

Cited by 31 publications

(17 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the addition of plasticizer is vital for the formation of strong and elastic films due to their ability to interact with polymer chains, reducing the intermolecular interaction of the polymeric three-dimensional network and providing greater flexibility and resistance. In addition to these effects, plasticizers also play an important role in modulating the drug release from the polymeric films [ 27 , 28 ]. In this current study, the films without plasticizer were fragile and brittle, which led us to use glycerol as plasticizer at a concentration of 10%.…”

Section: Resultsmentioning

confidence: 99%

N-acylhydrazone Derivative-Loaded Cellulose Acetate Films: Thermoanalytical, Spectroscopic, Mechanical and Morphological Characterization

et al. 2021

View full text Add to dashboard Cite

Cellulose acetate (ACT) is one of the most important cellulose derivatives due to its biodegradability and low toxicity, presenting itself as one of the main substitutes for synthetic materials in the development of wound dressing films. The incorporation of a N-acylhydrazonic derivative (JR19), with its promising anti-inflammatory activity, may represent an alternative for the treatment of skin wounds. This work aims to develop and to physicochemically and mechanically characterize ACT films containing JR19. The films were prepared using the ‘casting’ method and further characterized by thermoanalytical and spectroscopic techniques. In addition, mechanical tests and morphological analysis were performed. Thermogravimetry (TG) and differential scanning calorimetry (DSC) analyses showed that the thermal events attributed to excipients and films were similar, indicating the absence of physical incompatibilities between ACT and JR19. Infrared spectroscopy showed that JR19 was incorporated into ACT films. The characteristic band attributed to C≡N (2279 to 2264 cm−1) was observed in the spectra of JR19, in that of the physical mixture of JR19/ACT, and, to a lesser extent, in the spectra of JR19 incorporated into the ACT film, suggesting some interaction between JR19 and ACT. X-ray diffraction (XRD) evidenced the suppression of the crystallinity of JR19 (diffraction peaks at 8.54°, 12.80°, 14.09°, 16.08°, 18.19°, 22.65°, 23.59°, 24.53°, 25.70°, 28.16° and 30.27°2θ) after incorporation into ACT films. The mechanical tests indicated the adequate integrity of the films and their resistance to bending. The morphological characterization showed JR19 crystals along with a homogeneously distributed porous structure throughout the surface of the films with an average diameter of 21.34 µm and 22.65 µm of the films alone and of those incorporating JR19F, respectively. This study was able to characterize the ACT films incorporating JR19, showing their potential to be further developed as wound healing dressings.

show abstract

Section: Resultsmentioning

confidence: 99%

N-acylhydrazone Derivative-Loaded Cellulose Acetate Films: Thermoanalytical, Spectroscopic, Mechanical and Morphological Characterization

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Generally, water soluble plasticizers tend to leach out when exposed to dissolution medium and thereby create pores, which allow faster drug release. The increase in water soluble plasticizers concentration causes more pore formation resulting in a very fast release . Changing polymer concentration (X B ) from 250 to 400 mg significantly affects the %Q 5min ( P < 0.0001).…”

Section: Resultsmentioning

confidence: 99%

Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open-angle glaucoma in rabbits

El-Feky

Mostafa

Al-Sawahli

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objective To enhance bioavailability of timolol (TML) and utilize alternatives for traditional eye drops for more patient compliance, this study was aiming to develop biodegradable orally dissolving strips (ODSs) of TML for treatment of primary open‐angle glaucoma (POAG). Methods Novel ODSs of TML were formulated and optimized using solvent casting method according to full factorial design (31.22). TML ODSs were characterized with respect to many parameters. In‐vivo test was carried out using four groups of 24 New Zealand albino rabbits. POAG was induced by subconjunctival treatment of betamethasone. Histopathological examination and oxidative stress markers assay were carried out. Key findings The optimized formula (F9) exhibited a remarkably 15‐s disintegration time and 96% dissolution rate after 10 min. The results revealed a potent significant inhibitory effect of the optimized TML ODS to reduce IOP in induced rabbits in comparison with control rabbits and TML eye drops‐treated rabbits. The formula showed also high activity against oxidative stress and absence of histopathological changes in iridocorneal angle and cornea. Conclusion The ODSs could be a promising alternative delivery system for eye drops with more compliance to enhance delivery and therapeutic activity of TML in treatment of POAG.

show abstract

“…A formulation of SafeMedWaste for solid medications was designed with promising results: full denaturation of 15 different solid medications was demonstrated via LC–MS in 48–72 h. These drugs included time-release formulations of amphetamine salts and morphine, which contain complex excipients to slowly release the API 26 , 27 . Several benzodiazepines were included as well, as these represent a commonly prescribed class of medications with abuse liability 28 – 30 .…”

Section: Discussionmentioning

confidence: 99%

Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications

Leishman¹,

Wang²,

Channu³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Substance use disorders are a significant public health issue. Options to dispose of controlled medications are limited, increasing the risk of diversion. Providing an alternative for disposal, a chemical denaturant, SafeMedWaste, was designed to destroy controlled substances irreversibly and safely be placed in non-hazardous landfills. Via HPLC–MS, four formulations of SafeMedWaste were tested with 34 different liquid controlled medications from DEA schedules I–V. Beta testing assessed the efficacy of SafeMedWaste in a clinical setting and on waste generated in a manufacturing setting. Furthermore, a formulation of SafeMedWaste was tested on solid controlled medications. All 34 of the liquid medications tested (e.g., amphetamine, diazepam, fentanyl, ketamine) were fully destroyed in SafeMedWaste within 2–24 h. Analysis of a beta test sample of SafeMedWaste containing fentanyl, midazolam, and morphine waste collected in a hospital showed full denaturation of these drugs in 24 h. Variants of SafeMedWaste were optimized to denature six different controlled substance waste samples from a manufacturing facility. In contrast to side-by-side studies with a charcoal disposal system using the same drugs, SafeMedWaste fully inactivated and destroyed the controlled substances in the waste streams. Another formulation of SafeMedWaste was tested on solid medications, which were fully denatured in 48–72 h. In conclusion, SafeMedWaste irreversibly denatures controlled medications that present a problem in our society.

show abstract

Role of plasticizer in membrane coated extended release oral drug delivery system

Cited by 31 publications

References 65 publications

N-acylhydrazone Derivative-Loaded Cellulose Acetate Films: Thermoanalytical, Spectroscopic, Mechanical and Morphological Characterization

N-acylhydrazone Derivative-Loaded Cellulose Acetate Films: Thermoanalytical, Spectroscopic, Mechanical and Morphological Characterization

Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open-angle glaucoma in rabbits

Development and implementation of SafeMedWaste, a chemical denaturant for non-hazardous disposal of controlled medications

Contact Info

Product

Resources

About