Role of platelet-rich plasma in chronic alopecia areata: Our centre experience

Singh, Shalendra

doi:10.4103/0970-0358.155271

Cited by 72 publications

(62 citation statements)

References 11 publications

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“…In a study conducted by Singh, 20 patients of AA were treated with PRP alone; all the patients received six sessions of PRP at 4-week intervals. This study indicated good preliminary results and relapse in only one patient with no side effects (Singh, 2015).…”

Section: Discussionsupporting

confidence: 60%

The Effect of Platelet Rich Plasma on Hair Re‐growth in Patients with Alopecia Areata Totalis: a Clinical Pilot Study

Khademi

Tehranchinia

Abdollahimajd

et al. 2019

Dermatologic Therapy

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Autologous rich plasma (PRP) is blood plasma with enhanced concentration of platelets and is enriched with several growth factors which stimulate tissue regeneration. The current study aimed to investigate the effect of PRP on hair regrowth in patients with alopecia areata (AA) totalis. Ten subjects (28.9 ± 6.28 years; five males and five females) with clinically diagnosed AA totalis for at least 3 years who had not received any treatment within 3 months prior to the study were recruited. Blood sample was collected in thrombocyte harvesting tubes. The PRP was separated via centrifugation. The patients' scalp was divided sagittally into two approximately equal parts. In each patient, 4 mL of PRP was injected intradermally into the left or right side of the scalp; in each point, 0.1 mL of PRP was injected. Each patient was followed up monthly for 4 months. No hair regrowth was seen in eight patients and in two patients only <10% hair regrowth was observed. Totally, no significant effect was found for PRP on hair regrowth (p > .05). There was no side effect during treatment. Single dermal PRP injection did not prove to have any effect on hair regrowth in these patients.

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Section: Discussionsupporting

confidence: 60%

The Effect of Platelet Rich Plasma on Hair Re‐growth in Patients with Alopecia Areata Totalis: a Clinical Pilot Study

Khademi

Tehranchinia

Abdollahimajd

et al. 2019

Dermatologic Therapy

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“…Singh () performed a prospective study to evaluate the efficacy of PRP in the treatment of chronic AA. None of their patients had any side effects, and all of them tolerated the procedure well.…”

Section: Discussionmentioning

confidence: 99%

Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: A trichoscopic evaluation

Taieb

Ibrahim

Nada

et al. 2016

Dermatologic Therapy

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Alopecia areata is a common cause of nonscarring alopecia that occurs in a patchy, confluent, or diffuse pattern. Dermoscopy is a noninvasive technique for the clinical diagnosis of many skin diseases. Topical minoxidil solution 5% and platelet rich plasma are important modalities used in treatment of alopecia areata. We aimed to evaluate the efficacy of PRP versus topical minoxidil 5% in the treatment of AA by clinical evaluation and trichoscopic examination. Ninety patients were allocated into three groups; the first was treated with topical minoxidil 5% solution, the second with platelets rich plasma injections, and the third with placebo. Diagnosis and follow up were done by serial digital camera photography of lesions and dermoscopic scan before and every 1 month after treatment for 3 months. Patients treated with minoxidil 5% and platelets rich plasma both have significant hair growth than placebo (p < .05). Patients treated with platelets rich plasma had an earlier response in the form of hair regrowth, reduction in short vellus hair and dystrophic hair unlike patients treated with minoxidil and control (p < .05). In conclusion, platelets rich plasma is more effective in the treatment of alopecia areata than topical minoxidil 5% as evaluated by clinical and trichoscopic examination.

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“…Singh et al, reported that none of the patients had any side effects after PRP, and all of them tolerated the procedure well. 17 There was no burning or itching in any patients in our case. Trink et al, reported significant reduction in these features with PRP treatment.…”

Section: Dermoscopy) A) Baseline (To) B) Month 3 (T1) C) Month 6 (mentioning

confidence: 45%

A randomized, double blind, placebo controlled, split patch study to evaluate the effects of platelet rich plasma on alopecia areata

2018

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Background: Alopecia Areata is a T-cell–mediated autoimmune, often reversible disease in which the gradual loss of protection provided by immune privilege of the normal hair follicle plays an important role. It manifests as smooth, slightly erythematous (peach color) or normal-colored alopecic patches with short broken hair at the margins. It involves scalp most commonly, although other regions of body may be affected. Platelet rich plasma is an autologous concentration of platelets with a greater count in a small volume of plasma. Study aimed to evaluate the safety and efficacy of PRP therapy in Alopecia Areata.Methods: In this randomised, placebo controlled, split patch study, 30 patients of AA were recruited and injected with 1-1.5ml of autologous PRP made by double spin method into half the bald patch area and other half with placebo using insulin syringe once a month for 3 months. Outcome was assessed at the end of study by clinical photographs as regrowth of hair, dermoscopy findings as reduction in black dots, yellow dots and exclamation hair and Physician and patient self-assessment score.Results: Administration of autologous PRP has led to observable improvement in 20% case of PRP and only 3.3% of control cases. Decrease in number of dystrophic hair and hair regrowth with PRP was seen in 20% cases and in 17% patches.Conclusions: PRP in our setting was found to be minimally effective, but more efficacious than no treatment, and safe for AA patients.

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Role of platelet-rich plasma in chronic alopecia areata: Our centre experience

Cited by 72 publications

References 11 publications

The Effect of Platelet Rich Plasma on Hair Re‐growth in Patients with Alopecia Areata Totalis: a Clinical Pilot Study

The Effect of Platelet Rich Plasma on Hair Re‐growth in Patients with Alopecia Areata Totalis: a Clinical Pilot Study

Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: A trichoscopic evaluation

A randomized, double blind, placebo controlled, split patch study to evaluate the effects of platelet rich plasma on alopecia areata

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