Role of porosity and pore architecture in the <i>in vivo</i> bone regeneration capacity of biodegradable glass scaffolds

Sanzana, Edgardo S.; Navarro, Melba; Ginebra, Maria‐Pau; Planell, Josep A.; Ojeda, Alvaro C.; Montecinos, Hernán

doi:10.1002/jbm.a.34845

Cited by 49 publications

(28 citation statements)

References 23 publications

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“…As mentioned before, all the printed scaffolds feature the same porosity regardless their different designs. Bearing in mind that trabecular bone has a porosity of roughly 80 % [3] and the fact that numerous researchers [24][25][26][27][28] have manufactured scaffolds with 82 % porosity percentage using HA, it was decided that our printed scaffold will feature 82 % porosity as well. The deviation between the CAD-idealized structures and the corresponding printed ones is less than 2 %, a percentage which is in full agreement with the literature [23] and is considered negligible.…”

Section: Scaffold Design and Preparationmentioning

confidence: 99%

3D printing-assisted design of scaffold structures

Kantaros

Chatzidai

Karalekas

2015

Int J Adv Manuf Technol

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Rapid prototyping has emerged as a very auspicious manufacturing method of fabricating tissue engineering scaffolds. Using a 3D CAD design, the 3D printer features the ability of producing the predetermined forms and structures with very high level of accuracy and repeatability. Additionally, the 3D-printed tissue scaffolds are meant to act as replaceable constructs in a very demanding environment. The challenging conditions of the human body set high criteria demands that the scaffold should be capable of fulfilling. One of the most crucial demands is the capability of the scaffold to exhibit the desired mechanical properties depending on the loading conditions that it must cope up against. A mechanical property investigation of different scaffold designs can provide crucial information concerning this key factor in the criteria profile of a functional scaffold design. The target of the present study is to compare the mechanical properties of different scaffold designs that, however, feature same porosity and similar dimensions. Compressive strength testing was conducted in three 3D-printed scaffold designs. Also, a finite element study was conducted, simulating the compressive strength testing. The results of the compression testing experiment were found to be in good agreement with the computational analysis results. Furthermore, a computational fluid dynamic (CFD) simulation was conducted in order to look into the fluid shear stress inside the scaffold. Finally, the properties of the biomaterial hydroxyapatite were used in order to investigate the compressive and shear mechanical behavior of the aforementioned designs by conducting a finite element study.

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Section: Scaffold Design and Preparationmentioning

confidence: 99%

3D printing-assisted design of scaffold structures

Kantaros

Chatzidai

Karalekas

2015

Int J Adv Manuf Technol

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“…11,12 By dissolving in the surrounding fluid, bioactive glasses also resorb in vivo. 6,13,14 Thus, by combining these two families of materials, fully bioresorbable scaffolds with remarkable mechanical and bioactive properties can be produced. However, biodegradation is a complex mechanism influenced by several biological connected factors, as for example fluid pH and infiltration, oxygen supply, and enzyme activity, 15,16 so an exact control of the process is difficult to achieve, especially if it aims to satisfy precise expectations, such as a specific degradation rate or a time-scaled product release.…”

Section: Introductionmentioning

confidence: 99%

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Sachot¹,

Roguska²,

Planell³

et al. 2017

IJN

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The success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the graft surface and, more precisely, on its capacity to biodegrade in a well-defined manner (nature of ions released, surface-to-volume ratio, dissolution profile of this release, rate of material resorption, and preservation of mechanical properties). The assessment of the biological behavior of temporary templates is therefore very important in tissue engineering, especially for composites, which usually exhibit complicated degradation behavior. Here, blended polylactic acid (PLA) calcium phosphate ORMOGLASS (organically modified glass) nanofibrous mats have been incubated up to 4 weeks in physiological simulated conditions, and their morphological, topographical, and chemical changes have been investigated. The results showed that a significant loss of inorganic phase occurred at the beginning of the immersion and the ORMOGLASS maintained a stable composition afterward throughout the degradation period. As a whole, the nanostructured scaffolds underwent fast and heterogeneous degradation. This study reveals that an angiogenic calcium-rich environment can be achieved through fast-degrading ORMOGLASS/PLA blended fibers, which seems to be an excellent alternative for guided bone regeneration.

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“…Several studies have showed that, by introducing a bone-bioactive inorganic component (n-HAp) into the PCL matrix, better interaction and improved cell adhesion with the biological environment can be achieved [13]. It is well known that interconnected pores in tissue engineering scaffolds are essential for cell growth, migration, vascularization, and tissue formation [14]. Electrospinning is a process that can generate a fibrous scaffold with high porosity, interconnected pores, a large surface-area-to-volume ratio and a variable fiber diameter [15].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application

Rajzer

2014

J Mater Sci

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In this study, two techniques, namely electrospinning and needle-punching processes, were used to fabricate bioactive polycaprolactone/hydroxyapatite scaffolds with a final bilayer nano-/micro-fibrous porous structure. A hybrid scaffold was fabricated to combine the beneficial properties of nanofibers and microfibers and to create a three-dimensional porous structure (which is usually very difficult to produce using electrospinning technology only). The first part of this work focused on determining the conditions necessary to fabricate nano-and micro-fibrous components of scaffold layers. A characterization of scaffold components, with respect to their morphology, fiber diameter, pore size, wettability, chemical composition and mechanical properties, was performed. Then, the same process parameters were applied to produce a hybrid bilayer scaffold by electrospinning the nanofibers directly onto the micro-fibrous nonwovens obtained in a traditional mechanical needle-punching process. In the second part, the bioactive character of a hybrid nano-/ micro-fibrous scaffold in simulated body fluid (SBF) was assessed. Spherical calcium phosphate was precipitated onto the nano-/micro-fibrous scaffold surface proving its bioactivity.

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Role of porosity and pore architecture in the in vivo bone regeneration capacity of biodegradable glass scaffolds

Cited by 49 publications

References 23 publications

3D printing-assisted design of scaffold structures

3D printing-assisted design of scaffold structures

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Fabrication of bioactive polycaprolactone/hydroxyapatite scaffolds with final bilayer nano-/micro-fibrous structures for tissue engineering application

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