Role of portal haemodynamic parameters in prediction of oesophageal varices in cirrhotic patients

Mahmoud, Hasan Sedeek; Mostafa, Eman; Mohammed, Mohammed A.W.

doi:10.1016/j.ajg.2014.09.001

Cited by 15 publications

(19 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different predictors for the detection of OVs with variable degrees of accuracy were evaluated; including laboratory and imaging techniques. Doppler US for hepatic hemodynamic also was evaluated in this field [11].…”

Section: Discussionmentioning

confidence: 99%

Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis

Mahmoud¹,

Ghweil²,

Bazeed³

et al. 2015

OJGas

View full text Add to dashboard Cite

Background: Bleeding esophageal varices (OVs) due to portal hypertension are one of the major complications with high mortality in liver cirrhosis. So, early detection and management are mandatory. Aim: To evaluate the role of Von Willebrand factor (VWF) in predicting the presence of OVs. Patients and Methods: 62 patients with liver cirrhosis representing different Child-Pugh classes were included. The diagnosis of liver cirrhosis was based on the combination of clinical, laboratory and US examinations. All included patients underwent the following investigations: complete blood count, liver function tests (ALT, AST, serum bilirubin, albumin and total protein, prothrombin time (PT) and concentration (PC), INR and serum alkaline phosphatase), serum creatinine, Von Willebrand factor antigen (VWF-Ag) measurement and abdominal US. Upper endoscopic evaluation was done to detect presence or absence of varices (esophageal or gastric) and/or PHG. Results: 38 males and 24 females with their mean age (46 ± 12 years old) were included. Plasma Von Willebrand factor-Ag level was significantly higher in patients with OVs than those without varices (P value = 0.000). Also, its level was significantly higher in patients with higher grade of OVs, G3 than those with G1 or G2 (P value = 0.000). Patients with large OVs including those with G2 and G3 showed significantly higher values of VWF than those with small OVs (NO and G1) (P value = 0.000). VWF was independent predictor for detecting the presence of OVs with good sensitivity (90), specificity (77.3) and accuracy (85.5) at a cutoff value of 1.74 U/ml. Also it was an independent predictor for detecting the presence of large OVs with good sensitivity (91.2), specificity (85.7) and accuracy (88.7) at a cutoff value of 2.16 U/ml. Conclusion: VWF-Ag could be used as a non invasive laboratory independent predictor for the detection of OVs.

show abstract

Section: Discussionmentioning

confidence: 99%

Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis

Mahmoud¹,

Ghweil²,

Bazeed³

et al. 2015

OJGas

View full text Add to dashboard Cite

show abstract

“…Also, it can be used to stage the disease as early or late cirrhosis. Further analytical studies may confirm the use of congestion index as a significant prognostic factor in the evaluation of several liver diseases (Yin XY, Lu MD, Huang JF, Xie XY, Liang LJ, 2016, Kayacetin E, Efe D, & Doğan C, 2016, Mahmoud HS, Mostafa EF, & Mohammed MAW, 2016.…”

Section: Discussionmentioning

confidence: 88%

Untitled

2019

jhms

View full text Add to dashboard Cite

Background: Maternal mortality rates and Neonatal Mortality rates have remained to be unexpectedly high in sub-Saharan Africa. High magnitude of pregnancy and childbirth complications mainly due to home delivery. Identifying and solving barriers to facility delivery has remained to be a challenge. Methods: A descriptive cross sectional study to assess the cultural barriers impeding facility based delivery in the Maasai communities of Orkesumet ward of Simanjiro district, Northern Tanzania was conducted. Expert opinions from Maasai leaders, in-depth interviews, focused group discussion and observations were applied. Results: Expert opinions presented historical and current traditional practice in herbal medicine commonly used during childbirth in the remote Maasai Orkesumet ward. In-depth interview reported five main themes of "home delivery is safe", "Traditional medicine is better", "Giving birth is a blessing from God", "Bleeding can be controlled by traditional medicine" and "There is no hope from hospitals". FGD reported four main themes that "Female attendants are better", "Migration, transport cost and quality of care at health facility disturbs the continuum of care", "It is risky to be treated at the hospitals" and "Husbands are the key and mislead the communities". Observations provided evidences for herbal products that are commonly used. Conclusion: The Maasai present a strong trust and beliefs on their cultural, customs and traditional for home delivery while using innovative herbal medicine. They have negative attitudes towards a facility based delivery due to facility reported maternal deaths, quality of care for supplies and hygiene, distance and health care workers gender and attitudes.

show abstract

“…Accordingly, alternative diagnostic modalities, which are readily available and well-tolerated, should be actively explored. Several alternative methods for predicting the presence of EVs in liver cirrhosis have been proposed, including computed tomography (CT) (3)(4)(5)(6)(7)(8), magnetic resonance (MR) (3), serum markers (9)(10)(11), ultrasonographic parameters (12)(13)(14), liver stiffness measurement (LSM) (15)(16)(17), spleen stiffness measurement (SSM) (15,17,18), platelet count to spleen diameter ratio (PSR) (19,20) and capsule endoscopy (21,22).…”

Section: Introductionmentioning

confidence: 99%

“…Among them, SPI and CI have higher diagnostic accuracy. Their sensitivity and specificity were greater than 80% (12)(13)(14); (4) SSM has a higher diagnosis accuracy than LSM and PSR (15,17). The sensitivity and specificity of SSM were 78% and 76%, respectively (18); (5) the sensitivity and specificity of capsule endoscopy for the presence of EV were 73.7% and 90.5%, respectively (21).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of contrast‐enhanced computed tomography for esophageal varices in liver cirrhosis: a retrospective observational study

Deng

Zhang

et al. 2017

J Evidence Based Medicine

View full text Add to dashboard Cite

show abstract

Role of portal haemodynamic parameters in prediction of oesophageal varices in cirrhotic patients

Cited by 15 publications

References 22 publications

Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis

Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis

Untitled

Diagnostic accuracy of contrast‐enhanced computed tomography for esophageal varices in liver cirrhosis: a retrospective observational study

Contact Info

Product

Resources

About