Role of potato protein hydrolysate and exercise in preventing high‐fat diet‐induced hepatocyte apoptosis in senescence‐accelerated mouse

Abstract

Nonalcoholic fatty liver disease (NAFLD) is considered to be a serious clinical complication, which could cause significant liver dysfunction including fibrosis, cirrhosis, and cancer. Obesity could lead to NAFLD and contributes to liver disorder and related complicated liver diseases. Effect of exercise combined with alcalase treatment derived potato protein hydrolysate (APPH) on high-fat diet (HFD)-induced hepatic injury was investigated in senescence accelerated mouse-prone 8 (SAMP8) mice in the present study. Mice were divided into six groups (n = 6): Group I-Control, Group II-HFD, Group III-Exercise, Group IV-HFD + APPH, Group V-HFD + Exercise, and Group VI-HFD + Exercise + APPH. Combined APPH treatment and exercise offer better cytoprotection in HFD-induced histological changes than APPH treatment and exercise alone. Further, APPH and exercise activate the cell survival proteins PI3K/Akt and prevent FasL/FADD-mediated apoptosis in HFD fed SAMP8 mouse. APPH with swimming exercise effectively modulate HFD-induced liver damage and apoptosis in aged mice through activation of PI3K/Akt protein. How to cite this article: Chuang H-L, Baskaran R, Hsuan Day C, et al. Role of potato protein hydrolysate and exercise in preventing high-fat diet-induced hepatocyte apoptosis in senescence-accelerated mouse.

Potato protein hydrolysate inhibits RANKL‐induced osteoclast development by inhibiting osteoclastogenic genes via the NF‐κB/MAPKs signaling pathways

“…PP902 refers to a potato protein that undergoes hydrolysis with alcalase for a duration of 2 h. It contains 9% of 200 ppm hydrolysates and exhibits lipolysis‐stimulating characteristics, offering potential bioactivities 26 . Our research findings revealed that potato protein hydrolysate (PPH) exhibits a range of bioactivities, encompassing antioxidative, antidiabetic, anti‐sarcopenia, anti‐aging, hepatoprotective, cardioprotective, and renal protective effects 25,26,32–34 . In one of our recent studies, we demonstrated that a decapeptide derived from potato hydrolysate has the capacity to promote myogenic differentiation and alleviate the detrimental effects of high glucose‐associated alteration in protein synthesis and mitochondrial biogenesis in myoblasts 25 …”

“…26 Our research findings revealed that potato protein hydrolysate (PPH) exhibits a range of bioactivities, encompassing antioxidative, antidiabetic, anti-sarcopenia, anti-aging, hepatoprotective, cardioprotective, and renal protective effects. 25,26,[32][33][34] In one of our recent studies, we demonstrated that a decapeptide derived from potato hydrolysate has the capacity to promote myogenic differentiation and alleviate the detrimental effects of high glucose-associated alteration in protein synthesis and mitochondrial biogenesis in myoblasts. 25 Extensive evidence has established that inflammation constitutes a significant contributing factor to the development of osteoporosis and other bone-related disorders.…”

Targeted hydrolysis of native potato protein: A novel route for obtaining hydrolysates with improved interfacial properties

“…Enzymatically released peptides may display better functional properties than their parent protein molecules and consequently exhibit higher activity in food systems (Kamnerdpetch, Weiss, Kasper, & Scheper, 2007;Moreno et al, 1993). Moreover, potato protein hydrolysates have also been shown to have beneficial health effects in vivo (Chuang et al, 2020), illustrating their potential as both a functional and bioactive ingredients. Amphiphilic surfactants are widely used as emulsifiers as they contain both hydrophobic and hydrophilic regions, which are capable of reorganising at the oil-water interface and thereby stabilize the emulsion by decreasing the interfacial tension between the two immiscible liquids (McClements & Jafari, 2018).…”

“…Enzymatically released peptides may display better functional properties than their parent protein molecules and consequently exhibit higher activity in food systems (Kamnerdpetch, Weiss, Kasper, & Scheper, 2007; Moreno et al, 1993). Moreover, potato protein hydrolysates have also been shown to have beneficial health effects in vivo (Chuang et al, 2020), illustrating their potential as both a functional and bioactive ingredients.…”