Role of PPO–PEO–PPO triblock copolymers in phase transitions of a PEO–PPO–PEO triblock copolymer in aqueous solution

Liu, Sijun; Bao, Huihui; Li, Lin

doi:10.1016/j.eurpolymj.2015.08.016

Cited by 23 publications

(36 citation statements)

References 62 publications

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“…Pluoronic F-127 (PL) (Fig. 1b) is a synthetic amphiphilic copolymer of ethylene oxide and propylene oxide which has been investigated extensively for improvement of wettability, solubility/dissolution, stability and bioavailability of drugs in different formulations (Wong et al, 2006, Dumortier et al, 2006, Park et al, 2009, Cespi et al, 2012, Liu et al, 2015). The chemical name of PL is 2-[2-(2-hydroxyethoxy)propoxy]ethanol (Wong et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

Alshehri

Shakeel

Ibrahim

et al. 2019

Saudi Pharmaceutical Journal

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Apigenin (APG) is a poorly soluble bioactive compound/nutraceutical which shows poor bioavailability upon oral administration. Hence, the objective of this research work was to develop APG solid dispersions (SDs) using different techniques with the expectation to obtain improvement in its in vitro dissolution rate and in vivo bioavailability upon oral administration. Different SDs of APG were prepared by microwave, melted and kneaded technology using pluronic-F127 (PL) as a carrier. Prepared SDs were characterized using “thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infra-red (FTIR) spectrometer, powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM)”. After characterization, prepared SDs of APG were studied for in vitro drug release/dissolution profile and in vivo pharmacokinetic studies. The results of TGA, DSC, FTIR, PXRD and SEM indicated successful formation of APG SDs. In vitro dissolution experiments suggested significant release of APG from all SDs (67.39–84.13%) in comparison with control (32.74%). Optimized SD of APG from each technology was subjected to in vivo pharmacokinetic study in rats. The results indicated significant improvement in oral absorption of APG from SD prepared using microwave and melted technology in comparison with pure drug and commercial capsule. The enhancement in oral bioavailability of APG from microwave SD (319.19%) was 3.19 fold as compared with marketed capsule (100.00%). Significant enhancement in the dissolution rate and oral absorption of APG from SD suggested that developed SD systems can be successfully used for oral drug delivery system of APG.

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Section: Introductionmentioning

confidence: 99%

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

Alshehri

Shakeel

Ibrahim

et al. 2019

Saudi Pharmaceutical Journal

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“…WPUU-25 and WPUU-38 showed higher viscosity values than WPUU-7 and WPUU-17 because the first two formulations contained higher amounts of PEGbased segments, which improved the interactions with the aqueous phase. In addition, PEG-b-PPG may form hydrogels and micelles in water, increasing the surface of the polymer due to the swelling of the particles (45,46). Figure 3 shows viscosity values plotted against shear force for the aqueous systems, at 25°C.…”

Section: Apparent Viscositymentioning

confidence: 99%

“…In vitro dissolution studies of KTZ-loaded WPUU samples, in simulated gastric juice (pH 1.2) and simulated intestinal fluids (pH 7.4) were used to mimic the physiological conditions (45). In Figure 8, the release profiles of KTZ are shown.…”

Section: Dissolution Profile -In Vitro Release Studiesmentioning

confidence: 99%

Waterborne poly(urethane-urea)s films as a sustained release system for ketoconazole

et al. 2019

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Ketoconazole (KTZ) was incorporated in waterborne poly(urethane-urea)s dispersions (WPUU), aiming at the production of films for drug sustained release. Dispersions based on poly(ethylene glycol-block-propylene glycol) (PEG-b-PPG) (four monomers with different contents of PEG hydrophilic segments), poly(propylene glycol), isophorone diisocyanate, dime-thylolpropionic acid and hydrazine were produced and characterized by apparent viscosity and average particle size (APS). Cast films-drug interaction was investigated by Fourier-Transform infrared spectrometry (FTIR). In vitro dissolution assays were performed in simulated gastrointestinal juices, followed by application of kinetic models. Stable pseudoplastic dispersions, with APS between 27 to 320 nm were obtained. FTIR from KTZ-loaded films indicated interactions between polymer and drug. In vitro release of KTZ was achieved above 80%, notably influenced by PEG-based segments content up to 2 h, followed by sustained release for 8 h. Higuchi’s and first-order equations described the drug kinetic profile, as diffusion of the drug and erosion of the swollen polymer, respectively.

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“…PEG 4000 and Kolliphor® P 407 share close chemical structure (Liu et al, 2015). PEG 4000 is a hydrophilic compound and used largely in pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

“…Kolliphor® P 407 (also known as poloxamer 407), consists of hydrophobic and hydrophilic parts. It is amphiphilic in nature and can form micelles upon reaching specific critical micelle concentration (CMC) (Liu et al, 2015, Cespi et al, 2012). Both polymers have been used extensively to enhance active pharmaceutical ingredients (APIs) overall bioavailability (Park et al, 2009, Betageri and Makarla, 1995, Moneghini et al, 2001, Dumortier et al, 2006, Wong et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion

Altamimi

Elzayat

Qamar

et al. 2019

Saudi Pharmaceutical Journal

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This study was conducted to formulate, characterize, and investigate the bioavailability of hydrocortisone (HCT) when prepared as solid dispersions. HCT was mixed in an organic solvent with polyethylene glycol 4000 (PEG 4000) and Kolliphor® P 407. Spray drying technique was employed to form a solid dispersion formulation at a specific ratio. Physical and chemical characterization of the formed particles were achieved using differential scanning calorimetry, scanning electron microscopy, Fourier transform infrared spectroscopy, and powder X-ray diffractometry. Furthermore, comparative in vitro and in vivo studies were conducted between the formulated particles against neat HCT. The formulated solid dispersion showed elongated particles with leaf-like structure. Formation of new chemical bonds in the formed particle was suggested due to the change in the vibrational wave numbers and the significant improvement in the bioavailability of the dispersed particles proved the importance of this technique.

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Role of PPO–PEO–PPO triblock copolymers in phase transitions of a PEO–PPO–PEO triblock copolymer in aqueous solution

Cited by 23 publications

References 62 publications

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

Waterborne poly(urethane-urea)s films as a sustained release system for ketoconazole

Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion

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