Role of prebiotics in enhancing the function of next-generation probiotics in gut microbiota

Fei, Yiqiu; Chen, Zuobing; Zhang, Shuobo; Zhang, Tianfang; Lu, Yao; Berglund, Björn; Xiao, Hang; Li, Lanjuan; Yao, Mingfei

doi:10.1080/10408398.2021.1958744

Cited by 52 publications

(32 citation statements)

References 198 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GpS can reduce polyps in Apc Min/+ mice, and promote the growth of Bifidobacterium animalis ( B. animalis ), which suppresses CRC development [76] . This findings reveal that prebiotics can enhance the function of probiotics and the combination of them can prevent gut tumorigenesis [77] …”

Section: Strategies Of Microbe-based Managementmentioning

confidence: 88%

“…[76] This findings reveal that prebiotics can enhance the function of probiotics and the combination of them can prevent gut tumorigenesis. [77] Postbiotics are soluble factors secreted by live bacteria or released after bacterial lysis. [78] Postbiotics include inactivated microbial cells, cell fractions and cell metabolites.…”

Section: Prebiotics and Postbioticsmentioning

confidence: 99%

See 1 more Smart Citation

Microbe-based management for colorectal cancer

Gao

Cui

Yan

et al. 2021

Chinese Medical Journal

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the most prevalent, most lethal cancers in the world. Increasing evidence suggests that the intestinal microbiota is closely related to the pathogenesis and prognosis of CRC. The normal microbiota plays an essential role in maintaining gut barrier function and the immune microenvironment. Recent studies have identified carcinogenic bacteria such as enterotoxigenic Bacteroides fragilis ( ETBF ) and Streptococcus gallolyticus ( S. gallolyticus ), as well as protective bacterial such as Akkermansia muciniphila ( A. muciniphila ), as potential targets of CRC treatment. Gut microbiota modulation aims to restore gut dysbiosis, regulate the intestinal immune system and prevent from pathogen invasion, all of which are beneficial for CRC prevention and prognosis. The utility of probiotics, prebiotics, postbiotics, fecal microbiota transplantation and dietary inventions to treat CRC makes them novel microbe-based management tools. In this review, we describe the mechanisms involved in bacteria-derived colorectal carcinogenesis and summarized novel bacteria-related therapies for CRC. In summary, we hope to facilitate clinical applications of intestinal bacteria for preventing and treating CRC.

show abstract

Section: Strategies Of Microbe-based Managementmentioning

confidence: 88%

Section: Prebiotics and Postbioticsmentioning

confidence: 99%

Microbe-based management for colorectal cancer

Gao

Cui

Yan

et al. 2021

Chinese Medical Journal

View full text Add to dashboard Cite

show abstract

“…Prebiotics are substrates that are selectively utilized by the gut microbiota and promote human health (Cunningham et al, 2021). Previous studies have found that prebiotics can enhance the function of probiotics in gut microbiota and can delay the progression of immune diseases such as type 1 diabetes and acute pancreatitis by regulating the homeostasis of gut microbiota and the production of SCFAs (Fei et al, 2021). Studying the utilization of prebiotics by probiotics will contribute to the precise enrichment of target probiotics and improve their abundance.…”

Section: Discussionmentioning

confidence: 99%

Functional Characterization of Clostridium tyrobutyricum L319: A Promising Next-Generation Probiotic for Short-Chain Fatty Acid Production

et al. 2022

View full text Add to dashboard Cite

Probiotics contribute a lot to human health and the occurrence of diseases. Correspondingly, probiotics’ safety evaluation and probiotic properties have received increasing attention in the food industry and disease treatment. Clostridium tyrobutyricum L319 is a short-chain fatty acid (SCFA)-producing strain isolated from Grana Padano cheese with a blowing defect. Our previous study has shown its safety at the genomic level. This study focused more on the safety evaluation and probiotic properties in vitro. According to the results, this strain has no potential virulence factors or the possibility of antibiotic resistance genes propagation. It also fulfilled several criteria to be used as a probiotic, including significant hydrophobicity under an acidic condition (pH 5.0) and resistance to simulate gastric juice and intestinal juice. Additionally, this strain was found to be tolerant to the harsh conditions of the external environment, including resistance to low (20°C) and high (50°C) temperatures, high salts (3% NaCl), and low pH (pH 5.0). Finally, we found that this strain could ferment prebiotics, such as chito-oligosaccharides, to produce SCFAs. It exhibited excellent growth performance whether using chito-oligosaccharide as a sole carbon source or combining glucose as the mixed carbon source. Furthermore, chito-oligosaccharide and glucose (1:1) mixed carbon sources were the optimal strategy for the production of SCFAs. Our findings demonstrated that this strain might be considered a promising candidate for future use as a probiotic to promote health benefits.

show abstract

“…3 Oligosaccharides are indigestible, and therefore, reach the large intestine and are selectively taken up by Bifidobacteria, promoting their proliferation and improving intestinal microbiota. 4 In addition, they produce short-chain fatty acids (SCFAs) to lower the pH of the intestine, improve the characteristics of feces, suppress intestinal decay, and improve immunity and allergy. 5,6 Therefore, ingestion of indigestible oligosaccharides should theoretically prevent diseases caused by intestinal microbial imbalance, but there are limited studies that have reported the effects of indigestible oligosaccharides on allergic reactions.…”

Section: Introductionmentioning

confidence: 99%