Role of Prehypertension in the Development of Coronary Atherosclerosis in Japan

Washio, Masakazu; Shoji, Tetsuo; Yoshimasu, Kouichi; Kodama, Hiroko; Liu, Ying; Sasazuki, Shizuka; Tanaka, Keitaro; Kono, Suminori; Mohri, Masahiro; Takeshita, Akira; Arakawa, Kikuo; Ideishi, Munehito; Nii, Takenobu; Shirai, Kohji; Arai, Hidekazu; Doi, Yoshiko; Kawano, Teruaki; Nakagaki, Osamu; Takada, Kazuyuki; Hiyamuta, Kohji; Koyanagi, Satoru

doi:10.2188/jea.14.57

Cited by 43 publications

(35 citation statements)

References 34 publications

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“…Prehypertension is associated with subclinical atherosclerosis, including increased coronary atherosclerosis and increased arterial intima-media thickness. In addition, prehypertension is associated with elevated C-reactive protein, tumour necrosis factor α, homocysteine, oxidized low-density lipoprotein cholesterol and other inflammatory markers [9,12,13].…”

Section: Discussionmentioning

confidence: 99%

Prehypertension among young adult females in Dammam, Saudi Arabia

Koura

Al-Dabal²,

Rasheed³

et al. 2012

East Mediterr Health J

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Section: Discussionmentioning

confidence: 99%

Prehypertension among young adult females in Dammam, Saudi Arabia

Koura

Al-Dabal²,

Rasheed³

et al. 2012

East Mediterr Health J

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“…The magnitude of the increased cardiovascular disease risk related to the coexistence of prehypertension, glucose intolerance, and diabetes suggest that pharmacological intervention for blood pressure control in these groups may be warranted to prevent cardiovascular disease morbidity and mortality, as suggested by others. 19 A clinical trial is needed to confirm this. Increased age, higher body mass index, LDL cholesterol, and triglyceride levels, lower HDL levels, current smoking, ex-alcohol use, and male gender were all related to significantly increased cardiovascular disease risk.…”

Section: Discussionmentioning

confidence: 99%

Prehypertension, Diabetes, and Cardiovascular Disease Risk in a Population-Based Sample

et al. 2006

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Abstract-There are few data about the impact of the recently-defined category of prehypertension (systolic blood pressure 120 to 139 mm Hg or diastolic blood pressure 80 to 89 mm Hg) on cardiovascular disease incidence. It is also unknown whether this association differs between individuals with or without diabetes. A total of 2629 Strong Heart Study participants free from hypertension and cardiovascular disease at baseline examination were followed for 12 years to observe incident cardiovascular disease. Approximately 42% of the 2629 participants had diabetes. We assessed the prevalence of prehypertension and the hazard ratios of incident cardiovascular disease associated with prehypertension.

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“…12 In another longitudinal study, Winegarden 11 showed that, relative to normotensive subjects, the risk of hypertension was substantially higher among subjects with "high normal" BP (130 to 139/85 to 89 mm Hg). However, whereas several reports have documented an increased risk of CVD among prehypertensive subjects, 5,6,8,12,13 others suggest that prehypertension increases the risk of CVD only modestly or that this risk increases only when prehypertension is associated with additional risk factors. 4,7 Data on prehypertension in young adults are lacking, and little is known on the risk factors for prehypertension and their association with other CVD risk factors.…”

mentioning

confidence: 98%

Prevalence of Prehypertension and Associated Cardiovascular Risk Profiles Among Young Israeli Adults

et al. 2006

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Abstract-Recently the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure introduced the term "prehypertension" for systolic blood pressure levels of 120 to 139 mm Hg and diastolic BP levels of 80 to 89 mm Hg. Little is known about the prevalence of this entity and the cardiovascular risk factors associated with it. We aimed to determine the prevalence of prehypertension and the cardiovascular risk factors associated with it in a large population-based sample of young Israeli adults. We studied 36 424 Israel Defense Forces employees during the years 1991 to 1999. Subjects completed a detailed questionnaire and underwent physical examination, and blood samples were drawn after a 14-hour fast. Prehypertension was defined as a systolic blood pressure of 120 to 139 mm Hg, and/or a diastolic blood pressure of 80 to 89 mm Hg. We calculated the age-and sex-specific prevalence of prehypertension and other cardiovascular risk factors associated with this condition. Prehypertension was observed among 50.6% of men and 35.9% of women. The prehypertensive group had higher levels of blood glucose, total cholesterol, low-density lipoprotein cholesterol, and triglycerides, higher body mass index, and lower levels of high-density lipoprotein cholesterol than did the normotensive group. Multivariate logistic regression analysis showed that body mass index was the strongest predictor of prehypertension among both males and females (odds ratio, 1.100; 95% CI, 1.078 to 1.122 and odds ratio, 1.152; 95% CI, 1.097 to 1.21, respectively, for every 1 kg/m 2 increase). Our findings support the recommendation of lifestyle modification for prehypertensive patients. Further prospective studies are required to determine the role of pharmacotherapy in prehypertension. Key Words: cardiovascular diseases Ⅲ young adults Ⅲ hypertension, borderline H ypertension is likely the most common disease on Earth. 1 It is associated with an increased risk of morbidity and mortality from cardiovascular disease (CVD) and represents the single greatest preventable cause of death in humans. The standard definition of hypertension as blood pressure (BP) Ն140/90 mm Hg is based on the observation that the risk of CVD increases sharply above this level. However, recent data have shown that an increased risk of CVD is present in persons with BP levels as low as 115/ 70 mm Hg and that this risk increases steadily with rising BP. 2 The incremental association between BP and CVD risk has been reflected recently in the Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7). 3 In its report, the JNC7 introduced a new BP category, "prehypertension," defined as a systolic BP (SBP) of 120 to 139 mm Hg and/or a diastolic BP (DBP) of 80 to 89 mm Hg. Since the publication of the JNC7 report, several studies have assessed the prevalence and significance of prehypertension. Still, the importance of this entity in regard to global CVD risk and the pref...

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Role of Prehypertension in the Development of Coronary Atherosclerosis in Japan

Cited by 43 publications

References 34 publications

Prehypertension among young adult females in Dammam, Saudi Arabia

Prehypertension among young adult females in Dammam, Saudi Arabia

Prehypertension, Diabetes, and Cardiovascular Disease Risk in a Population-Based Sample

Prevalence of Prehypertension and Associated Cardiovascular Risk Profiles Among Young Israeli Adults

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