Role of presynaptic reuptake on dopamine modulation of cortico-striatal activity in TD learning

Wanjerkhede, Shesharao M.; Bapi, Raju S.

doi:10.1109/ijcnn.2005.1556232

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…It is observed that there is an effect of dopamine reuptake on the rate of formation of DA.D1 which is crucial for timing mechanisms involved in TD learning [14]. The rate of formation of DA.D1 decreases with increase in reuptake ( Figure 4).…”

Section: A Dopamine Transporter Activitymentioning

confidence: 96%

“…The ability of cocaine to bind to the DAT and to inhibit the re-uptake of DA has been strongly implicated in the reinforcing properties of cocaine [13]. It appears that the re-uptake affects the rate of formation of D 1.DA receptor complex which in tum would have a bearing on the timing mechanisms operating in TDL [14]. Therefore it becomes necessary to study the pre-synaptic re-uptake by dopamine transporter at synaptic cleft of spiny neuron.…”

Section: Initial Concentrations Of Signalling Moleculesmentioning

confidence: 99%

“…The ability of cocaine to bind to the DAT and to inhibit the re-uptake ofDA has been strongly implicated in the reinforcing properties of cocaine [13]. It also appears that the re-uptake affects the rate of formation of Dl.DA receptor complex [14]; and this may be affecting the phosphorylation ofDARPP-32. Therefore we undertook the study of the affects of pre-synaptic re-uptake of dopamine by dopamine transporter on the phosphorylation of DARPP-32.…”

Section: Introductionmentioning

confidence: 99%

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A Computational study of pre-synaptic re-uptake of dopamine on phosphorylation of DARPP-32

Wanjerkhede

Bapi

2009

2009 International Joint Conference on Neural Networks

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The activity of mid brain dopamine (DA) neurons resembles the reward prediction error signal of the Temporal Difference (TD) model. Dopamine acting at Dl receptor activates adenylate cyclase through the coupling of Dl receptors with G s / o l f • The complex of adenylate cyclase activates and increases the intracellular levels of cAMP and thereby stim ulating cAMP dependent protein kinase and increasing the state of phosphorylation of DARPP-32 (dopamine and cyclic AMPregulated phosphoprotein, M, = 32,000). DARPP-32 plays an important role in autophosphorylation of calcium calmodulin dependent protein kinaseII (CaMKII) which is crucial for prolongation of long term potentiation (LTP). Here we verified the effect of pre-synaptic re-uptake of dopamine by dopamine transporter on the phosphorylation of DARPP-32 and found that the phosphorylation of DARPP-32 is unaffected by presynaptic re-uptake. Further we have seen that the DARPP-32 phosphorylation does not change with the change in the DA or DIR concentrations.

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Section: A Dopamine Transporter Activitymentioning

confidence: 96%

Section: Initial Concentrations Of Signalling Moleculesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Computational study of pre-synaptic re-uptake of dopamine on phosphorylation of DARPP-32

Wanjerkhede

Bapi

2009

2009 International Joint Conference on Neural Networks

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“…They undertakeexperiments to investigate the mechanisms underlying the acquisition of sequential motor skills (such as typing) triggered by visual cues. A second area of interest in the laboratory is the modeling of biochemical signaling pathways involved in reinforcement learning [5].…”

Section: Learning Mechanismsmentioning

confidence: 99%

Neuroinformatics in India – Current Status and Future Directions

Singh

Advances in Cognitive Neurodynamics ICCN 2007

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Neuro-Informatics and computational neuroscience research in India has followed two directions -on the one hand research has focused on the use of computational approaches to understand neural processing. On the other hand research has been directed towards developing new tools that would benefit clinical research. In this paper we describe research initiatives undertaken in both areas and also discuss some new programs that been initiated at the recently commissioned National Facility for Functional Brain Imaging at the National Brain Research Centre.

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Modeling the sub-cellular signaling pathways involved in reinforcement learning at the striatum

Wanjerkhede¹,

Bapi²

2007

Progress in Brain Research

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Role of presynaptic reuptake on dopamine modulation of cortico-striatal activity in TD learning

Cited by 3 publications

References 19 publications

A Computational study of pre-synaptic re-uptake of dopamine on phosphorylation of DARPP-32

A Computational study of pre-synaptic re-uptake of dopamine on phosphorylation of DARPP-32

Neuroinformatics in India – Current Status and Future Directions

Modeling the sub-cellular signaling pathways involved in reinforcement learning at the striatum

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