Role of Probiotics in Health and Disease –A Review

Sen, Madhumita

doi:10.31632/ijalsr.2019v02i02.001

Cited by 37 publications

(23 citation statements)

References 43 publications

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“…Probiotics are functional foods that have been demonstrated to be effective treatments to control several diseases such as inflammatory bowel disease, allergy, diarrhea, etc. [7]. The gut is the key target for probiotics foods because it acts as the main interface between diet and metabolic pathways in human health as it modulates the intestinal microflora [8].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Lactobacillus spp. from Kefir Samples in Malaysia

et al. 2019

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Kefir is a homemade, natural fermented product comprised of a probiotic bacteria and yeast complex. Kefir consumption has been associated with many advantageous properties to general health, including as an antioxidative, anti-obesity, anti-inflammatory, anti-microbial, and anti-tumor moiety. This beverage is commonly found and consumed by people in the United States of America, China, France, Brazil, and Japan. Recently, the consumption of kefir has been popularized in other countries including Malaysia. The microflora in kefir from different countries differs due to variations in culture conditions and the starter media. Thus, this study was aimed at isolating and characterizing the lactic acid bacteria that are predominant in Malaysian kefir grains via macroscopic examination and 16S ribosomal RNA gene sequencing. The results revealed that the Malaysian kefir grains are dominated by three different strains of Lactobacillus strains, which are Lactobacillus harbinensis, Lactobacillusparacasei, and Lactobacillus plantarum. The probiotic properties of these strains, such as acid and bile salt tolerances, adherence ability to the intestinal mucosa, antibiotic resistance, and hemolytic test, were subsequently conducted and extensively studied. The isolated Lactobacillus spp. from kefir H maintained its survival rate within 3 h of incubation at pH 3 and pH 4 at 98.0 ± 3.3% and 96.1 ± 1.7% of bacteria growth and exhibited the highest survival at bile salt condition at 0.3% and 0.5%. The same isolate also showed high adherence ability to intestinal cells at 96.3 ± 0.01%, has antibiotic resistance towards ampicillin, penicillin, and tetracycline, and showed no hemolytic activity. In addition, the results of antioxidant activity tests demonstrated that isolated Lactobacillus spp. from kefir G possessed high antioxidant activities for total phenolic content (TPC), total flavonoid content (TFC), ferric reducing ability of plasma (FRAP), and 1,1-diphenyl-2-picryl-hydrazine (DPPH) assay compared to other isolates. From these data, all Lactobacillus spp. isolated from Malaysian kefir serve as promising candidates for probiotics foods and beverage since they exhibit potential probiotic properties and antioxidant activities.

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Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Lactobacillus spp. from Kefir Samples in Malaysia

et al. 2019

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“…According to the World Health Organization (WHO), probiotics are live bacteria that provide health benefits to the host when administrated in an adequate quantity. The use of living bacteria to treat gut diseases is as old as World War I when Alfred Nissle, a German physician and scientist, used an E. coli strain to treat diarrhea [ 68 ]. Now, different gut-associated microbial strains, typically from the genera Lactobacilli and Bifidobacteria , are available commercially as supplements to manipulate the gut microbiota to treat gastrointestinal related diseases.…”

Section: Gut Microbial Diversity Management Strategies To Treat Schiz...mentioning

confidence: 99%

Modulation of Gut Microbial Diversity through Non-Pharmaceutical Approaches to Treat Schizophrenia

Munawar

Ahmad

Anwar

et al. 2022

IJMS

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Schizophrenia (SCZ) is a psychotic syndrome with well-defined signs and symptoms but indecisive causes and effective treatment. Unknown underpinning reasons and no cure of the disease profoundly elevate the risk of illness. Gut microbial dysbiosis related metabolic dysfunction is providing a new angle to look at the potential causes and treatment options for schizophrenia. Because of the number of side effects, including gut dysbiosis, of traditional antipsychotic drugs, new alternative therapeutic options are under consideration. We propose that non-pharmacotherapy using biotherapeutic products could be a potent treatment to improve cognitive impairment and other symptoms of schizophrenia. Use of live microorganisms (probiotics), fibers (prebiotics), and polyphenols alone or in a mixture can maintain gut microbial diversity and improve the two-way relationship of the gut microbiota and the central nervous system. Fiber and polyphenol induced management of gut microbiota may positively influence the gut–brain axis by increasing the level of brain-derived neurotrophic factors involved in schizophrenia. Furthermore, we endorse the need for comprehensive clinical assessment and follow-up of psychobiotic (pro and prebiotics) treatment in mental illness to estimate the level of target recovery and disability reduction in schizophrenia.

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“…This is mainly due to the administration of B. breve and B. longum. A review containing 8,014 infants, children and adult with acute diarrhea were given probiotics which contains Bifidobacterium strains, the result were found to reduce the duration of diarrhea 22 . Antibiotic associated diarrhea in children and adult patients are also recommended to take probiotics along with antibiotics this have proven antibiotic donot interfere with the probiotics 23 .…”

Section: Health Benefits Of Bifidobacterium Bifidobacteria In Diarrhoeamentioning

confidence: 99%

“…A recent study has reported that probiotic supplements containing B. longum and other species of Bifidobacterium, suppress the total number of colon cancer cells in rats 26 . Many studies have concluded that certain strains of probiotics can be used as an adjuvant in cancer treatment 22 .…”

Section: Bifidobacteria In Colorectal Cancermentioning

confidence: 99%

Bifidobacterium sp as Probiotic Agent - Roles and Applications

Yakoob¹,

Pradeep²

2019

J Pure Appl Microbiol

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Probiotics are live microorganisms (mostly bacteria) that colonize the gut and supply helpful benefits. Probiotics are completely different from other varieties of microorganism in that they are considered "good" microorganism or non-pathogenic in healthy individuals. Genus Bifidobacterium is the primary microbe that colonizes human channel, and it has positive health effects on its host. Because of the acknowledged health benefits, it is included in several purposeful foods. Bifidobacteria generally occur in extremely varied ecological niches. In order to survive in these explicit ecological niches, they should be highly adaptive. This review helps researchers incorporate the utmost criteria for an acceptable probiotic strain as in the case of Bifidobacterium sp. Bifidobacteria can be considered as a probiotic and it plays an important role in anticholesterolemic, lactose intolerance, anticancerogenic, immunomodulatory effects etc.

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Role of Probiotics in Health and Disease –A Review

Cited by 37 publications

References 43 publications

Isolation and Characterization of Lactobacillus spp. from Kefir Samples in Malaysia

Isolation and Characterization of Lactobacillus spp. from Kefir Samples in Malaysia

Modulation of Gut Microbial Diversity through Non-Pharmaceutical Approaches to Treat Schizophrenia

Bifidobacterium sp as Probiotic Agent - Roles and Applications

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