Role of Procalcitonin in Infectious Gastroenteritis and Inflammatory Bowel Disease

Abstract

Our results indicate that PCT and CRP are comparably good diagnostic markers of bacterial GE but that PCT is not useful as in monitoring disease activity in patients with IBD.

The role of serum procalcitonin in the diagnosis of bacterial meningitis in adults: a systematic review and meta-analysis

“…The use of PCT to supplement the traditional gold standard would allow for an Furthermore, serum PCT levels, unlike that of CRP, have not been shown to be affected by nonsteroidal anti-inflammatory drugs, steroids, or inflammatory comorbidities such as inflammatory bowel disease, systemic lupus erythematosus or gout [52][53][54][55]. Additionally, PCT may be potentially useful in discriminating between bacterial and non-infectious etiologies of meningitis.…”

Use of Plasma Procalcitonin Levels as an Adjunct to Clinical Microbiology

“…PCT levels may help sort out the etiology of the fever in patients with the fever of unknown origin (FUO) syndrome, in that PCT levels do not increase in some of the disease entities that cause the FUO syndrome, e.g., Still's disease, systemic lupus erythematosus, and inflammatory bowel disease (6,10,36,40).…”

Mannose-binding lectin level and deficiency is not associated with inflammatory bowel diseases, disease phenotype, serology profile, and NOD2/CARD15 genotype in a large Hungarian cohort

“…The elevated CRP levels in patients with IBDs indicate disease activity rather than bacterial complications due to enhanced production of pro-inflammatory cytokines in the mesenteric fat [43]. Serum procalcitonin level, for which efficacy in the diagnosis of bacterial infection is superior to CRP and is often elevated in pneumonias [44], was not significantly different between active and inactive IBD [45]. These differences might substantially affect the MBL responsiveness, which only increases only 2-3-fold compared with CRP (10 -10,000-fold) upon an infectious challenge [17].…”