Role of Prolactin in Stress-Induced Biological Modifications in Animals

Prolactin as a protective factor in stress‐induced biological changes

“…It was found that the injection of microdoses of 6-OHDA into the corpus striatum, leading to the destruction of the dopamine nerve endings in this area, is followed by a total abolition of PRL cytoprotective action on stress-induced gastric ulcers. The same has been found after injection of 6-OHDA into the nucleus accumbens (33). These findings suggest that this effect of PRL is of central origin and involves both the nigrostrial and mesolimbic dopaminergic systems.…”

“…Thus, although ACTH does not show any ulcerogenic potency when injected in non-stressed animals, it potentiates the effects of physical stress in the development of gastric ulcers. Interestingly, this phenomenon is totally suppressed in animals with high levels of plasma PRL (33). Since the effect of ACTH may be mediated by peripheral corticosteroids, in this case, it is likely that the antagonism exerted by PRL takes place at a peripheral level.…”

“…This effect can be mimicked in animals injected i.c.v. with rat PRL or treated with the hyperprolactinemic agent, Recently, the role of central dopamine transmission in PRL cytoprotection has been studied in more detail (33). It was found that the injection of microdoses of 6-OHDA into the corpus striatum, leading to the destruction of the dopamine nerve endings in this area, is followed by a total abolition of PRL cytoprotective action on stress-induced gastric ulcers.…”

Amperometric glutamate biosensor based on chitosan enzyme film

“…The glutamate, which is frequently added to food as a flavor-enhancer in the form of MSG, can display, although rarely, adverse effects on humans[1]. Pyroglutamate, on the other hand, has been reported to be a memory-enhancer[30] and a potent antitumor agent with immune-modulatory activity in mice[31].…”

Impact of Prolonged High Altitude Exposure on Plasma Prolactin in Men: Effect of Age and Ethnicity

“…It is well known that PRL secretion is affected by stress and is a very sensitive marker of both physical and psychological stress in mammals (Fava and Guaraldi, 1987). Chronic stressful conditions are associated with an increase in PRL secretion and have multiple metabolic and behavioral effects that may contribute to a general adaptation syndrome, such as an increase in glucocorticoid secretion, enhanced pain threshold, induced defensive behavior, and stress-induced hyperthermia (Drago et al, 1989;Reis et al, 1998). However, its effects on physiological adjustments to the general adaptation syndrome are not clearly understood.…”