Role of Prostaglandins in the Pathogenesis of Acute Renal Failure

Oken, D.E.

doi:10.1016/s0140-6736(75)92321-1

Cited by 29 publications

(17 citation statements)

References 23 publications

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“…Furthermore, attempts to cause renal failure in experimental animals by infusion of either myoglobin or hemoglobin have been inconclusive; supplementary manipulations, such as the induction of hypotension and metabolic acidosis, have been necessary for renal injury to result (Mason et aL, 1963;Braun et ai, 1970;Oken, 1972;Knochel, 1976).…”

Section: Muscle Extract Infusion In Rabbitsmentioning

confidence: 99%

Muscle extract infusion in rabbits. A new experimental model of the crush syndrome.

Blachar¹,

Fong²,

Chadarévian³

et al. 1981

Circulation Research

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SUMMARY Previous studies provide inconclusive data concerning the nephrotoxicity of myoglobin following muscle injury. We investigated the possibility that released muscle constituents other than myoglobin may be associated with renal damage, and studied accompanying hematological and coagulation changes. An extract of homologous or autologous muscle was infused intravenously in rabbits in a dose of 100 mg of muscle extract protein/kg; equine myoglobin was given to control animal*. Experimental animals developed proteinuria, cylindruria, and a 50% reduction in glomemlar filtration rate. Leukopenia, thrombocytopenia and evidence of intravascular coagulation also were seen. The muscle extract was shown to have thromboplastlc activity; however inhibition of this by phospholipase C did not prevent the changes induced by muscle extract infusion possibly because the intrinsic coagulation pathway still was activated. Although moderate hypotension and ECG changes developed in some rabbits, these were not consistent and the renal functional changes appeared to be independent of these factors. Pulmonary and glomerular microthrombi were seen in experimental animals and there was vacuolation of the renal proximal tubular cells. These studies indicate that a number of biological systems are activated following muscle extract infusion and that these may be more important than the nephrotoxicity of myoglobin in the pathogenesis of the renal injury. Ore Res 49:114-124, 1981

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Section: Muscle Extract Infusion In Rabbitsmentioning

confidence: 99%

Muscle extract infusion in rabbits. A new experimental model of the crush syndrome.

Blachar¹,

Fong²,

Chadarévian³

et al. 1981

Circulation Research

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“…Oken [34] proposed the interesting hypothesis that the prostaglandins produced in the osmiophilic cells of the medulla enter the macula densa through Henle's loop and then counteract the effects of angiotensin. The amount produced in the renal cortex (which is very rich in 16-hydroxydehydrogenase, a substance destroying mainly the prostaglandins) is probably small.…”

Section: Prostaglandinsmentioning

confidence: 99%

Pathogenesis of Acute Noninflammatory Renal Failure

Börner¹,

Klinkmann²

1980

Nephron

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“…Furthermore, morphological studies contribute little to the sorting out of the pathogenesis of acute tubular necrosis with resultant acute renal failure. If acute renal failure results from a disruption of vascular events (35), tubular damage may be secondary, and it is not at all clear what it means to localize a toxin in one or another nephron segment.…”

Section: Measurement Of Secretionmentioning

confidence: 99%

“…For example, there is one school of thought that believes the acute renal failure syndrome is primarily attributable to severe cortical ischemia resulting form the interruption of blood flow to the kidney cortex (35 …”

Section: Measurement Of Secretionmentioning

confidence: 99%

Renal function tests: what do they mean? A review of renal anatomy, biochemistry, and physiology.

Berndt¹

1976

Environ Health Perspect

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Renal physiology, biochemistry, and anatomy are reviewed. For the most part, those aspects of these disciplines will be discussed which relate directly to the question of the evaluation of nephrotoxicity. In addition, emphasis is placed on those procedures and techniques which are useful in the evaluation of nephrotoxicity. A detailed discussion of histological and anatomical considerations is not given, since this is probably the least useful criterion for evaluation of renal damage. This information is intended as background for the remainder of the symposium which will be directed toward an understanding of specific nephrotoxicity phenomena.There are several references or textbooks in which suitable review material is available (1-4), all relatively up-to-date, and which present renal physiology and biochemistry in various degrees of thoroughness and complexity. The two monographs by Valtin and Sullivan are relatively fundamental, but both are thorough. Pitts' text is not only complete, but is also much more detailed than the previous two texts. The Handbook of Physiology presents the most detail of these four. Furthermore, this reference work contains many citations to the original literature, and can be used therefore as a guide to much of the original literature which pertains to renal physiology, biochemistry, and anatomy.The intrarenal localization of the nephron is depicted in Figure 1. The anatomical arrangements of the various nephron types are presented as they appear in situ. All nephrons have their glomeruli, proximal tubules, and distal tubules in the cortex. Only the loops of Henle of

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Role of Prostaglandins in the Pathogenesis of Acute Renal Failure

Cited by 29 publications

References 23 publications

Muscle extract infusion in rabbits. A new experimental model of the crush syndrome.

Muscle extract infusion in rabbits. A new experimental model of the crush syndrome.

Pathogenesis of Acute Noninflammatory Renal Failure

Renal function tests: what do they mean? A review of renal anatomy, biochemistry, and physiology.

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