Role of Pulvinar-Cortical Functional Brain Pathways in Attention-Deficit/Hyperactivity Disorder

Li, Xiaobo; Branch, Craig A.; Fuente, Angelica De La; Xia, Shugao

doi:10.1016/j.jaac.2013.04.016

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…A variety of existing clinical and neuroimaging studies have suggested that functional and structural abnormalities in the frontal and parietal areas (especially MFG and IPL) are associated with the onset of childhood ADHD. Both task-based and resting-state fMRI studies have reported functional alterations in MFG in children with ADHD (Li, Branch, De La Fuente, & Xia, 2013;Li, Sroubek, et al, 2012;Posner, Park, & Wang, 2014;Schulz et al, 2017;Yang et al, 2011). Decreased MFG cortical thickness has also been frequently reported in children with ADHD (Batty et al, 2010;Li et al, 2007;Shaw et al, 2006), and was found to be associated with the persistence of more severe childhood ADHD into adulthood (Rajendran et al, 2013;Shaw et al, 2006;Shaw et al, 2013).…”

Section: Discussionmentioning

confidence: 98%

Distinct topological properties of cue-evoked attention processing network in persisters and remitters of childhood ADHD

Luo

Schulz

Alvarez

et al. 2018

Cortex

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Attention deficit/hyperactivity disorder (ADHD) is a highly prevalent and impairing neurodevelopmental disorder that persists into adulthood in a sizeable portion of afflicted children. The persistence of ADHD elevates the risk for adverse outcomes that result in substantial individual and societal burden. The objective of this study is to assess neurobiological substrates associated with variability of clinical outcomes in childhood ADHD, which has considerable value for the development of novel interventions that target mechanisms associated with recovery. A total of 36 young adults who were diagnosed with ADHD combined-type during childhood and 33 group-matched controls were involved in the study. Adults with childhood ADHD were further divided into 17 persisters and 19 remitters based on DSM-5 criteria. Functional magnetic resonance imaging data during a cue-evoked attention task were collected from each subject. The cue-evoked attention processing network was constructed using graph theoretic techniques. Network properties, including global-, local-, and nodal-efficiency, and network hubs were computed. Group comparisons of the network properties were conducted. Significantly lower nodal efficiency in right inferior frontal gyrus and reduced left side frontal-parietal functional interactions were observed in both remitters and persisters relative to the controls. The ADHD persisters showed a unique pattern of significantly lower nodal efficiency in right middle frontal gyrus (MFG) and hyper-interactions between bilateral MFG. This study suggests that right MFG functional impairments may relate to inactive fronto-parietal functional interactions for sensory

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Section: Discussionmentioning

confidence: 98%

Distinct topological properties of cue-evoked attention processing network in persisters and remitters of childhood ADHD

Luo

Schulz

Alvarez

et al. 2018

Cortex

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“…During fNIRS data acquisition, all the subjects performed the VSAT which was designed to assess both the behavioral capacity of sustained attention and brain activation patterns. The VSAT is an enhanced block‐designed continuous performance task established in our previous functional magnetic resonance imaging studies . The task contained five task blocks interleaved by five rest blocks.…”

Section: Methodsmentioning

confidence: 99%

Altered cortical activation and connectivity patterns for visual attention processing in young adults post‐traumatic brain injury: A functional near infrared spectroscopy study

Mazzola²,

Catania

et al. 2018

CNS Neurosci Ther

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“…For head motion analyses, traditional measurement of the six translation and rotation parameters was first calculated from the rigid body transformation for head realignment. In addition, head motion effects in the blood oxygen-level dependent (BOLD) signals and their putative effects on FC patterns in the fMRI data were assessed by using the frame-wise measurements of the six realignment parameters (Li et al, 2013;Power et al, 2012). Finally, a band pass temporal filter of 0.01-0.1 Hz was applied.…”

Section: Rs-fmri Data Preprocessingmentioning

confidence: 99%

Structural and Functional Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder: A Focus on Subgenual Anterior Cingulate Cortex

Zhan

Liu

et al. 2017

Brain Connectivity

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Attention-deficit/hyperactivity disorder (ADHD), characterized by developmentally inappropriate inattention, hyperactivity/impulsivity, or a combination of both, is a major public health problem. Neuroimaging studies have revealed associations of these cognitive impairments with structural and functional deficits all over the brain. Existing findings are not fully consistent because of the heterogeneity of study samples and diversity of research techniques. In this study, we propose to utilize a multimodal magnetic resonance imaging (MRI) approach to study the structural and functional brain networks in children with ADHD-combined type (ADHD-C) with a focus on the subgenual anterior cingulate cortex (sgACC). Diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI) data from 32 children with ADHD-C and 32 group-matched controls were involved. Network-based statistic analysis of the rs-fMRI data revealed a disconnected functional network between the sgACC and multiple regions in the occipital lobe and cerebellum, whereas the DTI data showed disrupted white matter integrity in the subgenual cingulum bundle (sgCB). Post hoc region of interest (ROI)-based analyses showed significantly increased fluctuation of the spontaneous brain activity in the sgACC and higher radial diffusivity in the sgCB in the ADHD group. Both the rs-fMRI and DTI ROI-based measures were significantly correlated with clinical measures that examine behavioral capacities of attention and inhibitory control. Findings of this study suggest that functional alterations in the sgACC and white matter under development in the sgCB may impact each other, and together contribute to impaired attention and inhibitory control function in children with ADHD.

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Role of Pulvinar-Cortical Functional Brain Pathways in Attention-Deficit/Hyperactivity Disorder

Cited by 5 publications

References 2 publications

Distinct topological properties of cue-evoked attention processing network in persisters and remitters of childhood ADHD

Distinct topological properties of cue-evoked attention processing network in persisters and remitters of childhood ADHD

Altered cortical activation and connectivity patterns for visual attention processing in young adults post‐traumatic brain injury: A functional near infrared spectroscopy study

Structural and Functional Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder: A Focus on Subgenual Anterior Cingulate Cortex

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