Role of RASA1 in cancer: A review and update (Review)

Zhang, Yanhua; Li, Yue; Wang, Quanyue; Su, Bo; Xu, Hui; Sun, Yang; Sun, Pei; Li, Rumeng; Peng, Xiaochun; Cai, Jun

doi:10.3892/or.2020.7807

Cited by 43 publications

(37 citation statements)

References 126 publications

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“…The RASA1 gene plays an important role in controlling the angiogenesis process [27] . Studies have shown that reducing the function of the RASA1 gene interferes with the regulation of the angiogenesis process and causes various cancers, such as breast cancer [16] , [28] . It has been shown that increasing RASA1 levels by suppressing miR-145 can reduce the progression of ovarian cancer [29] .…”

Section: Discussionmentioning

confidence: 99%

“…RASA1 and NF1 proteins, which are RasGAPs (Ras-GTPase Activating Proteins), terminate the active Ras state by hydrolyzing GTP to GDP, thus negatively regulating the Ras pathway [15] . Accordingly, the development of various mutations and disruption of the expression of this tumor suppressor RasGAPs can lead to the formation of various types of cancers as well as endometriosis [16] , [17] .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of NF1 and RASA1 gene expression in endometriosis

Yarahmadi¹,

Dehghanian²,

Sandoghsaz³

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of NF1 and RASA1 gene expression in endometriosis

Yarahmadi¹,

Dehghanian²,

Sandoghsaz³

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Recent work has indicated the important involvement of RASA1 in capillary and arteriovenous malformations 36 . Moreover, RASA1 is capable of regulating neoplastic transformation and tumour progression 37 . In this article, RASA1 was identified as a direct and functional target of miR‐20a‐3p in modulating HaCaT keratinocyte migration.…”

Section: Discussionmentioning

confidence: 86%

“…36 Moreover, RASA1 is capable of regulating neoplastic transformation and tumour progression. 37 In this article, RASA1 was identified as a direct and functional target of miR-20a-3p in modulating HaCaT keratinocyte migration. Similarly, Shi et al ascertained that miR-31 enhanced keratinocyte migration and wound re-epithelialization phenotype via directly targeting RASA1.…”

Section: Discussionmentioning

confidence: 98%

Identification of the circ_PRKDC/miR‐20a‐3p/RASA1 axis in regulating HaCaT keratinocyte migration

Jiang

Liu

et al. 2021

Wound Repair Regeneration

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Migration of keratinocytes plays a crucial role in the re‐epithelialization phase during wound healing. Circular RNA (circRNA) protein kinase, DNA‐activated, catalytic subunit (circ_PRKDC, hsa_circ_0084443) has been identified as a regulator of keratinocyte migration. However, the molecular basis governing it remains unclear. The levels of circ_PRKDC, microRNA (miR)‐20a‐3p, and RAS p21 protein activator 1 (RASA1) were assessed by quantitative real‐time PCR (qRT‐PCR) or western blot. Subcellular localization, Actinomycin D, and Ribonuclease (RNase) R assays were performed to characterise circ_PRKDC. Cell migration was gauged by transwell and wound‐healing assays. A direct relationship between miR‐20a‐3p and circ_PRKDC or RASA1 was verified by dual‐luciferase reporter and RNA pull‐down assays. Circ_PRKDC expression was reduced in wound skin during wound healing. Circ_PRKDC modulated migration of HaCaT keratinocytes. Mechanistically, circ_PRKDC directly targeted miR‐20a‐3p. The regulation of circ_PRKDC on HaCaT keratinocyte migration was mediated by miR‐20a‐3p. RASA1 was identified as a direct and functional target of miR‐20a‐3p, and miR‐20a‐3p‐mediated inhibition of RASA1 impacted HaCaT keratinocyte migration. Circ_PRKDC acted as a post‐transcriptional modulator of RASA1 expression through miR‐20a‐3p. Moreover, circ_PRKDC modulated migration of HaCaT keratinocytes by RASA1. Our findings demonstrated a novel molecular basis, the miR‐20a‐3p/RASA1 axis, for the regulation of circ_PRKDC on HaCaT keratinocyte migration.

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“…SOD is an antioxidant enzyme that catalyzes the reactive oxygen species (ROS) into hydrogen peroxide and oxygen molecules to inhibit senescence and apoptosis ( Nguyen et al, 2020 ). RASA1 is a modulator of Ras GDP and GTP and plays an important role in several physiological processes such as angiogenesis, cell proliferation and apoptosis ( Zhang Y. et al, 2020 ). In addition, Lei et al observed that miR-132-3p expression was significantly up-regulated after femoral artery occlusion, and the hind limb perfusion recovery after ischemia was slower in knockout mice compared with wild-type mice ( Lei et al, 2015 ; Yue et al, 2018 ).…”

Section: Bone Microvascular Endothelial Cellsmentioning

confidence: 99%

Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment

Huang

Wen

Niu

et al. 2021

Front. Cell Dev. Biol.

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Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) in patients with immune-related diseases. Among various pathogenesis proposed, the mechanism related to impaired blood vessels is gradually becoming the most convincing hypothesis. Bone endothelial cells including bone microvascular endothelial cells (BMECs) and endothelial progenitor cells (EPCs) play a crucial role in the maintenance of vascular homeostasis. Therefore, bone endothelial cells are key regulators in the occurrence and progression of SONFH. Impaired angiogenesis, abnormal apoptosis, thrombosis and fat embolism caused by the dysfunctions of bone endothelial cells are considered to be the pathogenesis of SONFH. In addition, even with high disability rates, SONFH lacks effective therapeutic approach. Icariin (ICA, a flavonoid extracted from Epimedii Herba), pravastatin, and VO-OHpic (a potent inhibitor of PTEN) are candidate reagents to prevent and treat SONFH through improving above pathological processes. However, these reagents are still in the preclinical stage and will not be widely used temporarily. In this case, bone tissue engineering represented by co-transplantation of bone endothelial cells and bone marrow mesenchymal stem cells (BMSCs) may be another feasible therapeutic strategy.

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Role of RASA1 in cancer: A review and update (Review)

Cited by 43 publications

References 126 publications

Evaluation of NF1 and RASA1 gene expression in endometriosis

Evaluation of NF1 and RASA1 gene expression in endometriosis

Identification of the circ_PRKDC/miR‐20a‐3p/RASA1 axis in regulating HaCaT keratinocyte migration

Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment

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