Role of re-screening of cervical smears in internal quality control.

Baker, Anna; Melcher, D. H.; Smith, R. V.

doi:10.1136/jcp.48.11.1002

Cited by 40 publications

(55 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The proportions found in our study, 76% for the cytopathologists (gold standard) and 72% for rapid rescreening, are in agreement with those of other authors, who found that the diagnosis of ASCUS ranged between 74% and 84% of total positive diagnoses detected by rapid rescreening. 10,18,22 With reference to LSIL, other studies have reported frequencies ranging between 16% and 24%, 10,18,22 similar to those observed by us.Another advantage of 100% rapid rescreening is that it allows monitoring of individual performance, detecting professional shortcomings, differences and difficulties related to diagnostic interpretation. 26 Personnel responsible for routine screening may pay more attention and concentrate harder when they know that all the smears will be reviewed.…”

supporting

confidence: 75%

“…6-9 However, the objective of this standard procedure is not to reduce false negative rates but to act as an indicator of screening performance. [10][11][12][13][14] In fact, even when disagreements in diagnosis occur in a sample of 10%, the remaining 90% are not rescreened. This limitation will hinder any further identification of occasional shortcomings or discrepancies between cytotechnologists.…”

mentioning

confidence: 99%

“…First, several publications on the subject were presented and discussed. 10,16,17,21 Second, smears reported as negative by cytotechnologists during routine screening were used to train them in screening.Each of 5,215 smears was screened by 2 cytopathologists, and the concordant diagnoses were considered the gold standard for statistical purposes. The smears with discordant diagnoses were reviewed by a third cytopathologist, and the final diagnosis was reached at a consensus meeting of the 3 cytopathologists; this was considered the gold standard.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Quality Assurance in Cervical Smears

Amaral

Zeferino²,

Hardy³

et al. 2005

Acta Cytologica

View full text Add to dashboard Cite

supporting

confidence: 75%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Quality Assurance in Cervical Smears

Amaral

Zeferino²,

Hardy³

et al. 2005

Acta Cytologica

View full text Add to dashboard Cite

“…The greatest limitation of the RR-100% is its low sensitivity in detecting false-negatives and that there is no way of controlling the screener's and reviewer's performance since only the negative smears are reviewed [49]. Although RPS has limitations, the immediate feedback associated with it is believed to improve the performance of the screeners.…”

Section: Discussionmentioning

confidence: 99%

Internal Quality Control for Cervical Cytopathology: Comparison of Potential False-Negatives Detected at Rapid Prescreening and at 100% Rapid Review

Tavares¹,

Souza²,

Manrique³

et al. 2014

Acta Cytologica

View full text Add to dashboard Cite

Objective: To evaluate the performance of rapid prescreening (RPS) and 100% rapid review (RR-100%) as internal quality control (IQC) methods assessed by outcome at colposcopy, histopathology and repeat cytopathology for cases with false-negative results on cervical cytopathology at routine screening (RS). Study Design: Out of 12,208 cytology smears analyzed, 900 were abnormal. Of these, 656 were identified at RS, and 244 were false-negative, with 90.2% identified at RPS and 57.4% at RR-100%. Of the 900 abnormal cases, 436 were submitted for additional testing. Results: Of the 244 women with cytopathological abnormalities identified only by the IQC methods, 114 had supplementary examinations: 35 were submitted for colposcopy, 22 for biopsy and 99 for repeat cytopathology. The sensitivity of RPS for the detection of abnormalities identified on colposcopy, histopathology and repeat cytopathology was 87.5% (95% CI 67.6-97.3), 82.4% (95% CI 56.6-96.2) and 95.7% (95% CI 85.2-99.5), respectively. The sensitivity of RR-100% was 54.2% (95% CI 32.8-74.4), 52.9% (95% CI 27.8-77.0) and 47.8% (95% CI 32.9-63.1), respectively. RPS was more sensitive than RR-100% when compared to the findings on colposcopy (p = 0.011) and repeat cytopathology (p = 0.000). When compared to colposcopy, histopathology and repeat cytopathology, the sensitivity of RS was 83.2% (95% CI 76.1-88.9), 85.7% (95% CI 78.1-91.5) and 73.3% (95% CI 66.0-79.7), respectively. Conclusion: RPS performed better than RR-100% when compared to the results of colposcopy and repeat cytopathology.

show abstract

“…Rapid rescreening (RR) of all negative cases is more feasible and is a recommended QC procedure in the U.K. [12][13][14][15][16][17] Smears are rescreened rapidly (30 -120 sec per slide) using various screening patterns. 18 The strategy of RR has been shown to be superior to the 10% rescreening and has received widespread acceptance in Europe and Australia.…”

mentioning

confidence: 99%

Rapid prescreening of papanicolaou smears

Djemli

Khetani

Auger

2005

Cancer

View full text Add to dashboard Cite

Population stratification results from unequal, nonrandom genetic contribution of ancestors and should be reflected in the underlying genealogies. In Quebec, the distribution of Mendelian diseases points to local founder effects suggesting stratification of the contemporary French Canadian gene pool. Here we characterize the population structure through the analysis of the genetic contribution of 7,798 immigrant founders identified in the genealogies of 2,221 subjects partitioned in eight regions. In all but one region, about 90% of gene pools were contributed by early French founders. In the eastern region where this contribution was 76%, we observed higher contributions of Acadians, British and American Loyalists. To detect population stratification from genealogical data, we propose an approach based on principal component analysis (PCA) of immigrant founders' genetic contributions. This analysis was compared with a multidimensional scaling of pairwise kinship coefficients. Both methods showed evidence of a distinct identity of the northeastern and eastern regions and stratification of the regional populations correlated with geographical location along the St‐Lawrence River. In addition, we observed a West‐East decreasing gradient of diversity. Analysis of PC‐correlated founders illustrates the differential impact of early versus latter founders consistent with specific regional genetic patterns. These results highlight the importance of considering the geographic origin of samples in the design of genetic epidemiology studies conducted in Quebec. Moreover, our results demonstrate that the study of deep ascending genealogies can accurately reveal population structure. Am J Phys Anthropol, 2011. © 2010 Wiley‐Liss, Inc.

show abstract

Role of re-screening of cervical smears in internal quality control.

Cited by 40 publications

References 6 publications

Quality Assurance in Cervical Smears

Quality Assurance in Cervical Smears

Internal Quality Control for Cervical Cytopathology: Comparison of Potential False-Negatives Detected at Rapid Prescreening and at 100% Rapid Review

Rapid prescreening of papanicolaou smears

Contact Info

Product

Resources

About