Role of reactive oxygen species and antioxidants on pathophysiology of male reproduction

Maneesh, M; Jayalekshmi, H

doi:10.1007/bf02912918

Cited by 103 publications

(73 citation statements)

References 74 publications

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“…The most common ROS that have potential significance in reproductive biology, include the superoxide anion (O2-), hydrogen peroxide (H 2 O 2 ), the peroxyl (ROO-) and the hydroxyl (OH-) radicals [89,90]. Reactive oxygen species (ROS) has both physiological and pathological roles in male infertility.…”

Section: Free Radicalsmentioning

confidence: 99%

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Sharma¹

2017

Ann Clin Lab Res

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Infertility has become ominous problem. On an average, about 10% of all couples face difficulty in starting a family and this creates a feeling of great personal failure, particularly in India where religious and socio-economic traditions have made it almost imperative for everyone to have children. A significant association had been found between impaired semen quality including sperm count, motility and morphology. In this review, the various contributory etiological factors i.e., exposure to heavy metals, pesticides, industrial chemicals, endocrine factors, genetics causes and modern life style had been discussed which have a serious impact on male infertility. In this article we analyzed data from different sources and present evidences of the possible etiology and risk factors for male infertility. There is a need to emerge at the indiscriminate use and disposal of environmental chemicals. Especially pesticides and industrial chemicals as the chemicals enter the food chain, surface and ground water which had potential for exposure during the critical period of development further avoiding tobacco smoking, excessive alcoholism, excessive heat exposure to the testes can help in improving the semen quality.

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Section: Free Radicalsmentioning

confidence: 99%

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Sharma¹

2017

Ann Clin Lab Res

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“…In addition, as the spermatozoa plasma membrane contains a high level of polyunsaturated fatty acids (PUFA), it is susceptible to peroxidative damage. Lipid peroxidation (LPO) could lead to the damage of lipid matrix structure of sperm membrane, and could be affected in sperm flagellum and axonemal structure, and decrease their motility (15,16). occurrence of many diseases in males.…”

Section: Introductionmentioning

confidence: 99%

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

2017

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“…In order to enhance the protection of the sperm cell, it is possible to make use of antioxidants, compounds that combat ROS (MANEESH; JAYALEKSHMI, 2006;SIKKA, 1996SIKKA, , 2004. Fish semen has natural antioxidants, both inside and outside the cells, but there is great cytoplasmic loss during spermatogenesis, which leaves the spermatozoa basically dependent on the antioxidants of the seminal plasma.…”

Section: Introductionmentioning

confidence: 99%

Influence of vitamins C and E on the quality of cryopreserved semen Prochilodus brevis (Prochilodontidae, Teleostei)

Almeida‐Monteiro

Oliveira-Araújo

Lopes

et al. 2017

SCA

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Seminal cryopreservation allows the long-term conservation of gametes of various species, including endangered species, such as Prochilodus brevis. However, the application of this biotechnology can cause damage to sperm cells, reducing seminal quality. Thus, we have sought substances that minimize the damage caused by this process, such as antioxidants. Thus, this study aimed to evaluate the association between two cryoprotectants and two vitamins, in different concentrations, on the quality of cryopreserved semen of P. brevis. For cryopreservation, the experiment was performed in two stages. In the first stage, the semen of 10 animals was submitted to six different freezing means, coming from the combination of 5% glucose, two cryoprotectants (Dimethyl sulfoxide [DMSO] or Methyl glycol) and two vitamins (C or E to 0.0001 mg) for cryopreservation. In the second stage, semen samples of eight animals were diluted in 5% glucose and the best cryoprotectant found in the first stage, associated with three different concentrations of vitamins C or E (0.01, 0.001, and 0.0001 mg). In both steps, the in natura and post-thawed samples were submitted to kinetic analysis, morphology, and sperm membrane integrity. The cryopreserved semen with DMSO presented significantly higher results (p < 0.05) than that frozen with Methyl glycol, regardless of the vitamin used. The morphologically normal spermatozoa rate was higher (p < 0.05) in the vitamin-containing samples, however, vitamin E reduced sperm motility rates, independent of the cryoprotectant used. As for vitamin concentrations, higher motility rates were obtained when cryopreserved semen with 0.01 and 0.0001 mg of any of the vitamins. However, the higher concentration had a deleterious effect on the spermatic morphology of P. brevis. Therefore, the glucose associated with DMSO and the lower concentration of vitamin C provides good quality for the post-thawed semen of P. brevis. Key words: Antioxidants. Cryopreservation of semen. ResumoA criopreservação seminal permite a conservação em longo prazo dos gametas de diversas espécies, inclusive as ameaçadas, como a Prochilodus brevis. Contudo, a aplicação dessa biotecnologia pode causar danos às células espermáticas, reduzindo a qualidade seminal. Assim, tem-se buscado substâncias que minimizem os danos causados por esse processo, como os antioxidantes. Deste modo, este estudo objetivou avaliar a associação entre dois crioprotetores e duas vitaminas, em diferentes concentrações, sobre a qualidade do sêmen criopreservado de P. brevis. Para a criopreservação, o experimento foi realizado em duas etapas. Na primeira, o sêmen de 10 animais foi submetido a seis diferentes meios de congelação, oriundos da combinação de glicose 5%, dois crioprotetores (Dimetilsulfóxido [DMSO] ou Metilglicol) e duas vitaminas (C ou E a 0,0001 mg), para a criopreservação. Na segunda etapa, amostras de sêmen de oito animais foram diluídas em Glicose 5% e DMSO (melhor crioprotetor encontrado na primeira etapa), associados a três diferentes conce...

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Role of reactive oxygen species and antioxidants on pathophysiology of male reproduction

Cited by 103 publications

References 74 publications

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Male Infertility; Evidences, Risk Factors, Causes, Diagnosis and Management in Human

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

Influence of vitamins C and E on the quality of cryopreserved semen Prochilodus brevis (Prochilodontidae, Teleostei)

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