Role of Reactive Oxygen Species in the Correlation Between Host and Microbes

Kim, Suhyun; Lee, Dong Gun

doi:10.1007/978-981-13-8763-0_1

Cited by 1 publication

(2 citation statements)

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“…It has been suggested that prebiotics are better than next‐generation probiotics (such as F. prausnitizii ) as these are extremely sensitive to O 2 , therefore difficult to administer (Martín et al, 2017). To overcome this problem, recently prebiotic supplement from the gold kiwifruits has been launched by Anagenix, a New Zealand‐based company and it has been claimed that they have an important role in the growth of F. prausnitizii and their regaining in the GIT (Kim & Lee, 2019). Considering every possible aspect of the gut microbiota (culturable and unculturable) and microbial ROS, we conclude that ‘still there is a long way to go’ in understanding and micro‐managing the ROS.…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

“…Interestingly, negative effects are also associated with ROS when produced in excess. In brief, ROS are beneficial as well as harmful for the host (Di Meo et al, 2017), depending on the ROS level and site of production (Kim & Lee, 2019). This review is aimed at readers seeking an introductory overview about the impact of ROS on gut microbiota, as well as applied aspect of rebooting the gut microbial dysbiosis with probiotic interventions or faecal microbiota transplantation (FMT).…”

Section: Introductionmentioning

confidence: 99%

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Balancing reactive oxygen species generation by rebooting gut microbiota

Singh

Ahlawat

Mohan

et al. 2022

Journal of Applied Microbiology

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Reactive oxygen species (ROS; free radical form O 2 •− , superoxide radical; OH • , hydroxyl radical; ROO • , peroxyl; RO • , alkoxyl and non-radical form 1 O 2 , singlet oxygen; H 2 O 2 , hydrogen peroxide) are inevitable companions of aerobic life with crucial role in gut health. But, overwhelming production of ROS can cause serious damage to biomolecules. In this review, we have discussed several sources of ROS production that can be beneficial or dangerous to the human gut. Micro-organisms, organelles and enzymes play crucial role in ROS generation, where NOX1 is the main intestinal enzyme, which produce ROS in the intestine epithelial cells. Previous studies have reported that probiotics play significant role in gut homeostasis by checking the ROS generation, maintaining the antioxidant level, immune system and barrier protection. With current knowledge, we have critically analysed the available literature and presented the outcome in the form of bubble maps to suggest that the probiotics help in controlling the ROS-specific intestinal diseases, such as inflammatory bowel disease (IBD) and colon cancer. Finally, it has been concluded that rebooting of the gut microbiota with probiotics, postbiotics or faecal microbiota transplantation (FMT) can have crucial implications in the structuring of gut communities for the personalized management of the gastrointestinal (GI) diseases.

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Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%