Role of reactive oxygen species and TRP channels in the cough reflex

Taylor‐Clark, Thomas E.

doi:10.1016/j.ceca.2016.03.007

Cited by 49 publications

(30 citation statements)

References 158 publications

(195 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cough is one of the most recognizable symptoms of COPD. Oxidative stress may evoke profound effects on airway afferent nerves, particularly through the modulation of neuronal transient receptor potential channels [168]. …”

Section: Oxidative Stress In the Pathobiology Of Copdmentioning

confidence: 99%

The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease

Białas

Sitarek

Miłkowska-Dymanowska

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease, characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. The major risk factor of COPD, which has been proven in many studies, is the exposure to cigarette smoke. However, it is 15–20% of all smokers who develop COPD. This is why we should recognize the pathobiology of COPD as involving a complex interaction between several factors, including genetic vulnerability. Oxidant-antioxidant imbalance is recognized as one of the significant factors in COPD pathogenesis. Numerous exogenous and endogenous sources of ROS are present in pathobiology of COPD. One of endogenous sources of ROS is mitochondria. Although leakage of electrons from electron transport chain and forming of ROS are the effect of physiological functioning of mitochondria, there are various intra- and extracellular factors which may increase this amount and significantly contribute to oxidative-antioxidative imbalance. With the coexistence with impaired antioxidant defence, all these issues lead to oxidative and carbonyl stress. Both of these states play a significant role in pathobiology of COPD and may account for development of major comorbidities of this disease.

show abstract

Section: Oxidative Stress In the Pathobiology Of Copdmentioning

confidence: 99%

The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease

Białas

Sitarek

Miłkowska-Dymanowska

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…TRPA1 is also the molecular target for reactive and electrophilic by-products of oxidative stress. This also includes electrophiles such as hypochlorite and hydrogen peroxide (Taylor-Clark 2016). TRPA1 can also be indirectly activated by the inflammatory mediators PGE2 and bradykinin (Grace et al 2012).…”

Section: Coughmentioning

confidence: 99%

Itch and Cough – Similar Role of Sensory Nerves in Their Pathogenesis

Pecova

Kocan²,

Vyšehradský³

et al. 2020

Physiol Res

View full text Add to dashboard Cite

Itch is the most common chief complaint in patients visiting dermatology clinics and is analogous to cough and also sneeze of the lower and upper respiratory tract, all three of which are host actions trying to clear noxious stimuli. The pathomechanisms of these symptoms are not completely determined. The itch can originate from a variety of etiologies. Itch originates following the activation of peripheral sensory nerve endings following damage or exposure to inflammatory mediators. More than one sensory nerve subtype is thought to subserve pruriceptive itch which includes both unmyelinated C-fibers and thinly myelinated Aδ nerve fibers. There are a lot of mediators capable of stimulating these afferent nerves leading to itch. Cough and itch pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. The inflammation is involved in the development of chronic conditions of itch and cough. The aim of this review is to point out the role of sensory nerves in the pathogenesis of cough and itching. The common aspects of itch and cough could lead to new thoughts and perspectives in both fields.

show abstract

“…The disorder of TRP ion channel expression in asthma TRP channels are involved in inflammatory and structural changes in the respiratory tract resulting in the development of bronchial hyperreactivity and bronchospasm [67].…”

Section: Acidity Membrane Potential and Intracellular Calcium Ion Comentioning

confidence: 99%

“…On the one hand, the activation of these channels in the nerve endings of the respiratory tract leads to the stimulation of protective reflexes (cough, elevated mucus production, increased mucociliary clearance). On the other hand, it can be a pathogenetic basis for the formation of the disease under certain conditions [39,67]. The pathogenesis of the cough reflex involves the TRPV1 channel [39].…”

Section: Acidity Membrane Potential and Intracellular Calcium Ion Comentioning

confidence: 99%

Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma

et al. 2020

View full text Add to dashboard Cite

Asthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity. Dysfunction of transient receptor potential (TRP) ion channels underlies the development of neurogenic inflammation, bronchial hyperreactivity and respiratory symptoms of asthma such as bronchospasm and cough. TRP channels are expressed in the respiratory tract. Their activation is mediated by endogenous and exogenous factors involved in the pathogenesis of asthma. The study of functioning and regulation of TRP channels is relevant, as they could be important therapeutic targets for asthma. The aim of the review is to summarize modern ideas about the mechanisms of functioning and regulation of members of the TRP channel superfamily, the role of which in lung pathology and physiology are the best studied.

show abstract

Role of reactive oxygen species and TRP channels in the cough reflex

Cited by 49 publications

References 158 publications

The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease

The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease

Itch and Cough – Similar Role of Sensory Nerves in Their Pathogenesis

Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma

Contact Info

Product

Resources

About