Role of Reactive Oxygen Species in Cancer Progression

Kashyap, Dharambir; Tuli, Hardeep Singh; Sak, Katrin; Garg, Vivek Kumar; Goel, Neelam; Punia, Sandeep; Chaudhary, Ashun

doi:10.1007/s40495-019-00171-y

Cited by 56 publications

(22 citation statements)

References 90 publications

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“…The obtained epidemiological and experimental data from the numerous studies supported Virchow’s hypothesis and revealed that inflammatory processes regulate the course of cancer based on the level of inflammation-related factors, inflammatory cytokines, and chemokines, in the tumor microenvironment, either by producing an antitumor response or by inducing cell transformation and malignancy [30,31,32]. One of the major regulatory components in the relationship between cancer and chronic inflammation is ROS that has an ability to affect the type, presence, and levels of inflammation-modulating factors such as activator protein 1 (AP-1), β-catenin/Wnt (wingless related integration site), HIF-1α (hypoxia-inducible factor-1 alpha), NF-κB, PPAR-γ (peroxisome proliferator-activated receptor gamma), p53, inflammatory cytokines, chemokines, and growth factors [27,33,34,35]. However, it should be noted that there is a complex crosstalk between chronic inflammation, ROS accumulation, and cancer progression (Figure 2).…”

Section: Role Of Ros In Cancer Progressionmentioning

confidence: 99%

“…This causes an increased mutation load, defects in signal-transduction, inactivation of apoptosis, and overpowered generation of additional ROS that activate the inflammation-modulating factors, inflammatory cytokines, and chemokines [34,35,36,37]. Apart from the induction of chronic inflammation by ROS-mediated NF-κB activation, the active NF-κB is considered to be a key component in the rise of therapy-resistant cancers toward fractional gamma-irradiation therapy and chemotherapeutic agents such as 5-fluorouracil, bortezomib, cisplatin, daunorubicin, doxorubicin, paclitaxel, vinblastine, vincristine, and tamoxifen, through the transcriptional up-regulation of Akt, Bcl-2 (B-cell lymphoma 2), Bcl-xL (B-cell lymphoma- extra-large), cyclin D1, COX-2, survivin, and XIAP (X-linked inhibitor of apoptosis) [38,39,40,41,42,43].…”

Section: Role Of Ros In Cancer Progressionmentioning

confidence: 99%

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Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

et al. 2019

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Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration mediated effects. Interestingly, ROS also dynamically influences the tumor microenvironment and is known to initiate cancer angiogenesis, metastasis, and survival at different concentrations. At moderate concentration, ROS activates the cancer cell survival signaling cascade involving mitogen-activated protein kinase/extracellular signal-regulated protein kinases 1/2 (MAPK/ERK1/2), p38, c-Jun N-terminal kinase (JNK), and phosphoinositide-3-kinase/ protein kinase B (PI3K/Akt), which in turn activate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), matrix metalloproteinases (MMPs), and vascular endothelial growth factor (VEGF). At high concentrations, ROS can cause cancer cell apoptosis. Hence, it critically depends upon the ROS levels, to either augment tumorigenesis or lead to apoptosis. The major issue is targeting the dual actions of ROS effectively with respect to the concentration bias, which needs to be monitored carefully to impede tumor angiogenesis and metastasis for ROS to serve as potential therapeutic targets exogenously/endogenously. Overall, additional research is required to comprehend the potential of ROS as an effective anti-tumor modality and therapeutic target for treating malignancies.

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Section: Role Of Ros In Cancer Progressionmentioning

confidence: 99%

Section: Role Of Ros In Cancer Progressionmentioning

confidence: 99%

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

et al. 2019

Self Cite

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“…The level of intracellular ROS plays a crucial role in senescence occurrence (Panieri and Santoro, 2016), also closely associated with the principle of the metabolic process (Davalli et al, 2016) and various implications of cellular stress resulting from physiological maintenance of ROS metabolic enzymes in cancer cells (Kashyap et al, 2019). Several studies reported that out-level ROS over the threshold causes cell death or another type of permanent cell arrest as senescence (Ikawati et al, 2020;Larasati et al, 2018).…”

Section: Intracellular Ros Levelmentioning

confidence: 99%

A new curcumin analog, CCA-1.1, induces cell death and cell cycle arrest in WiDr colon cancer cells via ROS generation

Wulandari¹,

Ikawati²,

Kirihata³

et al. 2021

J Appl Pharm Sci

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The new Pentagamavunone-1 (PGV-1) derivative, chemoprevention-curcumin analog 1.1 (CCA-1.1), is described as an improved physicochemical feature with similar cytotoxic activity on colon cancer cells and binding interaction to various cancer biomarkers. The current study explored the cytotoxic activity related to its ability to promote physiological changes in the WiDr colon cancer cell line. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to assess the cell viability of WiDr and NIH-3T3 cells on the treatment of CCA-1.1 and PGV-1. 2′,7′-dichlorofluorescein diacetate staining, propidium iodide staining, and annexin V-PI staining were conducted to examine reactive oxygen species (ROS) level, cell cycle profiles, and apoptosis, respectively. For more examination on morphological changes, the SA-β-gal staining was used to detect senescence occurrence. We retrieved a more significant cytotoxic effect on WiDr by CCA-1.1 than PGV-1 and no effect on NIH-3T3 fibroblast cells. Our compound stimulated the arrest of the cell cycle at the G2/M phase, apoptosis, ROS generation, and senescence at an equal level to PGV-1. Altogether, these data reinforce CCA-1.1 as a viable alternative to PGV-1, attributed to its improved physicochemical features that are beneficial in designing dosage formulations for medical purposes.

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“…Considerable changes in ROS levels can potentially disrupt cellular functions and effects are reversed by the actions of respiratory enzymes, that assist in quenching ROS [84] .Oxidative stress results from an overproduction of ROS with relatively low amounts of the antioxidant to defend the body from harmful effects of ROS [85] . It has been known that increased levels of ROS are dangerous as they tend to cause dysregulation of many cellular components involved in pathogenesis of several diseases [86][87][88][89] . Under such pathological states, synthetic or nature-based antioxidants are taken with the intent to reduce high levels of ROS.…”

Section: Assessment Of the Total Phenolic Contentmentioning

confidence: 99%

Investigating the antioxidant potential of Streptomyces sp. MUSC 11 from mangrove soil in Malaysia

Kemung¹,

Tan²,

Chan³

et al. 2019

Prog Drug Discov Biomed Sci

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Streptomyces are a distinguished group of gram-positive bacteria mostly acknowledged for their immense contribution to life-saving drugs and lines of compounds with diverse bioactivities. To date, there remains limited studies on Streptomyces with biological activities residing in underexplored ecosystems such as the mangrove forests. For this purpose, the present work aimed at investigating the biological activity of Streptomyces sp. MUSC 11 collected from soil sample in mangrove forests, situated in the State of Pahang, Peninsular of Malaysia. The cultured strain resembled phenotypic and genotypic traits of genus Streptomyces. Investigations of the methanolic extract from Streptomyces sp. MUSC 11 revealed antioxidant activities in form of scavenging free radicals ABTS, DPPH, chelating iron and reducing ferric iron. Besides the antioxidant tests, antioxidant results corresponded well to the presence of phenolic content. In summary, Streptomyces derived from extreme and understudied ecosystem such as the mangrove forests are potential sources of biologically active and therapeutically useful compounds.

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Role of Reactive Oxygen Species in Cancer Progression

Cited by 56 publications

References 90 publications

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

A new curcumin analog, CCA-1.1, induces cell death and cell cycle arrest in WiDr colon cancer cells via ROS generation

Investigating the antioxidant potential of Streptomyces sp. MUSC 11 from mangrove soil in Malaysia

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