Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed tablets

Shi, Kejing; Salvage, Jonathan P.; Maniruzzaman, Mohammed; Nokhodchi, Ali

doi:10.1016/j.ijpharm.2021.120315

Cited by 75 publications

(41 citation statements)

References 60 publications

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“…The tested samples were paralepidids copying the geometry of the outlet of the extruder and did not present any tailored dimensions, porosity or surface to volume ratio that can be easily controllable by means of 3DP tablet design. Nevertheless, they exhibited slow drug release compared to the commercial tablet, but very fast compared to other formulations found in the literature [23,24,27,61]. This release rate can be controlled by designing the tablet geometry [62,63] or by modifying drug carrier matrix materials [64].…”

Section: Discussionmentioning

confidence: 94%

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Mendibil

Tena

Duque³

et al. 2021

Pharmaceutics

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Three-dimensional printed drug development is nowadays an active area in the pharmaceutical industry, where the search for an appropriate edible carrier that permits the thermal processing of the mixture at temperature levels that are safe for the drug is an important field of study. Here, potato starch and hydroxypropyl cellulose based mixtures loaded with paracetamol up to 50% in weight were processed by hot melt extrusion at 85 °C to test their suitability to be thermally processed. The extruded mixtures were tested by liquid chromatography to analyze their release curves and were thermally characterized. The drug recovery was observed to be highly dependent on the initial moisture level of the mixture, the samples being prepared with an addition of water at a ratio of 3% in weight proportional to the starch amount, highly soluble and easy to extrude. The release curves showed a slow and steady drug liberation compared to a commercially available paracetamol tablet, reaching the 100% of recovery at 60 min. The samples aged for 6 weeks showed slower drug release curves compared to fresh samples, this effect being attributable to the loss of moisture. The paracetamol loaded mixture in powder form was used to print pills with different sizes and geometries in a fused deposition modelling three-dimensional printer modified with a commercially available powder extrusion head, showing the potential of this formulation for use in personalized medicine.

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Section: Discussionmentioning

confidence: 94%

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Mendibil

Tena

Duque³

et al. 2021

Pharmaceutics

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“…It is important to note that Eudragit polymers can not only be used as a main component of the polymeric matrix but can also act as release modifiers and even as coating materials. Shi et al (2021) printed ibuprofen tablets by FDM using ethyl cellulose as the main polymer of the filaments, blended with other polymers (poly(vinyl alcohol), hydroxypropyl methylcellulose, ERL, ERS), which were added as release modifier excipients. In this context, the incorporation of ERL (20%) or ERS (20% and 10%) to these filaments and tablets resulted in a decrease in the drug release rate from tablets compared with those tablets prepared with other polymeric release modifiers.…”

Section: Fused Deposition Modelingmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

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“…In the years following the approval of Spritam®, research supporting the use of 3DP to fabricate bespoke pharmaceutical formulations began at an exponential pace [11][12][13][14][15][16][17][18][19][20]. Although 3DP was initially employed to produce simple tablets, the academic 3DP community soon developed the expertise to produce complex structures, polypills, drug-loaded medical devices, and 4D designs [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36].…”

Section: Moving 3dp Of Pharmaceuticals Beyond the Laboratory And Into The Clinicmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed tablets

Cited by 75 publications

References 60 publications

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Disrupting 3D printing of medicines with machine learning

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