Role of Repetitive Transcranial Magnetic Stimulation (rTMS) in Treatment of Addiction and Related Disorders: A Systematic Review

Makani, Ramkrishna; Pradhan, Basant; Shah, Umang; Parikh, Tapan

doi:10.2174/1874473710666171129225914

Cited by 23 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From a neurobiological perspective, the clinical beneficial effects of TMS over DlPfCx are supported by the evidence, which demonstrated the enhancement of dopaminergic activity in the midbrain (nucleus accumbens), which is depressed in addiction. 64 , 65 – 99 Two studies implemented the H-coil in the treatment of cocaine addiction, finding a significant reduction in craving and intake. 86 , 87 However, only one study considered the sham group, reporting a lasting reduction in cocaine intake, but no difference between the real and the control groups.…”

Section: Discussionmentioning

confidence: 99%

Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date

Bolloni¹,

Badas²,

Corona³

et al. 2018

SAR

View full text Add to dashboard Cite

There is a common consensus in considering substance-use disorders (SUDs) a devastating chronic illness with social and psychological impact. Despite significant progress in understanding the neurobiology of SUDs, therapeutic advances have proceeded at a slower pace, in particular for cocaine-use disorder (CUD). Transcranial magnetic stimulation (TMS) is gaining support as a safe and cost-effective tool in the treatment of SUDs. In this review, we consider human studies that have investigated the efficacy of TMS in achieving therapeutic benefits in treating CUD. All studies conducted to date that have evaluated the therapeutic effect of TMS in CUD are included. We focus on the protocol of stimulation applied, emphasizing the neurophysiological effects of coils employed related to outcomes. Moreover, we examine the subjective and objective measurements used to assess the therapeutic effects along the timeline considered. The revision of scientific literatures underscores the therapeutic potential of TMS in treating CUD. However, the variability in stimulation protocols applied and the lack of methodological control do not allow us to draw firm conclusions, and further studies are warranted to examine the interaction between TMS patterns of stimulation relative to clinical outcomes in depth.

show abstract

Section: Discussionmentioning

confidence: 99%

Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date

Bolloni¹,

Badas²,

Corona³

et al. 2018

SAR

View full text Add to dashboard Cite

show abstract

“…Further research is required to determine if these abnormalities are clinically significant and if these abnormalities could be used as an objective index of methamphetamine-induced damage and recovery in addiction and rehabilitation settings. The results may also guide exploration of the potential therapeutic use of rTMS for treatment of methamphetamine addiction (Makani et al, 2017).…”

Section: Discussionmentioning

confidence: 96%

Use of illicit amphetamines is associated with long-lasting changes in hand circuitry and control

Pearson-Dennett

Faulkner

Collie

et al. 2019

Clinical Neurophysiology

View full text Add to dashboard Cite

Highlights Elevated corticomotoneuronal excitability is present in abstinent male amphetamine users. Abstinent amphetamine users overestimate the grip force required to manipulate novel objects. Elevated excitability and grip force overestimation is present months to years after ending drug use.3 Abstract ObjectiveThe study aim was to determine if use of illicit amphetamines or ecstasy is associated with abnormal excitability of the corticomotoneuronal pathway and manipulation of novel objects with the hand. MethodsThree groups of adults aged 18-50 years were investigated: individuals with a history of illicit amphetamine use, individuals with a history of ecstasy use but minimal use of other stimulants, and non-drug users. Transcranial magnetic stimulation was delivered to the motor cortex and the electromyographic response (motor evoked potential; MEP) was recorded from a contralateral hand muscle. Participants also gripped and lifted a novel experimental object consisting of two strain gauges and an accelerometer. ResultsResting MEP amplitude was larger in the amphetamine group (6M, 6F) than the non-drug and ecstasy groups (p<0.005) in males but not females. Overestimation of grip force during manipulation of a novel object was observed in the amphetamine group (p=0.020) but not the ecstasy group. ConclusionsHistory of illicit amphetamine use, in particular methamphetamine, is associated with abnormal motor cortical and/or corticomotoneuronal excitability in males and abnormal manipulation of novel objects in both males and females. SignificanceAbnormal excitability and hand function is evident months to years after cessation of illicit amphetamine use. 4

show abstract

“…While we agree that buprenorphine combinations reduce societal harm and naltrexone injectable maybe a real important clinical option, can we find ways to promote ‘dopamine homeostasis” [9]. We are cognizant that most clinics want to do the right thing and strive to reduce recidivism rates [10].…”

mentioning

confidence: 99%

“…Continuing in this path will not produce different results. To be clear there may be other promising modalities other than MAT such as repetitive transcranial magnetic stimulation (rTMS) [10], exercise [11] and even new medications with positive allosteric modulators of GABA-A receptors [12], as well as the highly researched Genetic Addiction Risk Score (GARS) coupled with precision KB220Z to induce dopamine homeostasis [13] to effectively rebalance and restore healthier brain function by promoting effective cross talk between various brain regions (e.g. Nucleus accumbens, cingulate gyrus, hippocampus etc.)…”

mentioning

confidence: 99%

Death by Opioids: Are there non-addictive scientific solutions?

Downs¹,

Blum²,

Baron

et al. 2019

J Syst Integr Neurosci

View full text Add to dashboard Cite

In the face of the current Opioid crisis in America killing close to 800,000 people since 2004, we are proposing a novel approach to assist in at least attenuating these unwanted premature deaths. While we applaud the wonderful efforts of our governmental institutes and professional societies (NIDA, NIAAA, ASAM, ABAM ) in their extraordinary efforts in combating this continued dilemma, the current approach is failing, and other alternative approaches should at least be tested. These truths present a serious ethical dilemma to scientists, clinicians and counselors in the Reward Deficiency Syndrome (RDS) treatment community. It is important to realize that the current DSM-5 does not actually accurately display the natural brain reward process. The human brain has not been designed to carve out specific drugs like opioids, alcohol, nicotine, cocaine, benzodiazepines or cannabis and process addictions such as gambling as distinct endophenotypes. This is true in spite of natural ligands for cannabinoids, endorphins, or even benzodiazepines. The most accurate endophenotype is indeed reward dysfunction (e.g hypodopaminergic or hyperdopaminergic). With this mind, we are hereby proposing that the current Medication Assisted Treatment (i.e. ‘MAT’) expands to needed individuals as an initial “Band-Aid” to reduce harm avoidance, with the long–term goal of prophylaxis. So, to be clear, there may be other promising modalities other than MAT such as repetitive transcranial magnetic stimulation (rTMS), exercise and even new medications with positive allosteric modulators of GABA-A receptors, as well as the highly researched Genetic Addiction Risk Score (GARS) coupled with precision KB220Z. This will induce “dopamine homeostasis” to effectively rebalance and restore healthier brain function by promoting the cross talk between various brain regions (e.g. Nucleus accumbens, cingulate gyrus, hippocampus etc.) resulting in dopamine homeostasis. Our laudable goal is to not only save lives, but to redeem joy and improve the quality of life in the recovery community through scientifically sound natural non-addicting alternatives.

show abstract

Role of Repetitive Transcranial Magnetic Stimulation (rTMS) in Treatment of Addiction and Related Disorders: A Systematic Review

Abstract: rTMS may serve as an emerging therapeutic option for addiction and related disorders. The major lacunae include important methodological limitations and dearth of knowledge about precise mechanism of action that need to be addressed in the future studies.

Cited by 23 publications

References 0 publications

Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date

Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date

Use of illicit amphetamines is associated with long-lasting changes in hand circuitry and control

Death by Opioids: Are there non-addictive scientific solutions?

Contact Info

Product

Resources

About