2007
DOI: 10.1016/s0083-6729(06)75003-8
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Role of Retinoic Acid in the Differentiation of Embryonal Carcinoma and Embryonic Stem Cells

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Cited by 143 publications
(121 citation statements)
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“…In addition to hox genes, oct4, sox2, nanog3, GATA4, and GATA6 are identified as key regulators of the p19 cell differentiation (13). Our preliminary studies suggest that oct4 and GATA4 may be the downstream targets of Ajuba in P19 cells.…”
Section: Discussionmentioning
confidence: 72%
See 1 more Smart Citation
“…In addition to hox genes, oct4, sox2, nanog3, GATA4, and GATA6 are identified as key regulators of the p19 cell differentiation (13). Our preliminary studies suggest that oct4 and GATA4 may be the downstream targets of Ajuba in P19 cells.…”
Section: Discussionmentioning
confidence: 72%
“…In cell culture, the addition of alltrans retinoic acid (atRA) to P19 cells results in growth inhibition and differentiation. At low doses of atRA (10-20 nM), P19 cells differentiate from an ectodermal phenotype into endodermal-like cells, whereas higher concentrations of atRA (100-200 nM) induce terminal neuroectodermal differentiation (11)(12)(13). Collectively, these observations prompted us to hypothesize that Ajuba may interact with retinoic acid receptors to regulate retinoic acid signaling.…”
mentioning
confidence: 99%
“…Mouse P19 embryonic carcinoma cells are a well-characterized model for in vitro neuronal differentiation, which upon exposure to RA differentiate into neurons [23]. To determine the role of PHF8 in neuron differentiation, we knocked down PHF8 in P19 cells by two different PHF8-specific siRNAs (siPHF8-A and siPHF8-B) and examined their effect on RA-induced neuronal differentiation.…”
Section: Knockdown Of Phf8 Impairs Ra-induced Neuronal Differentiatiomentioning
confidence: 99%
“…Retinoic acid (RA) is widely used as a potent inducer of neural differentiation by multipotent cells of various types, such as neural stem cells, embryonal carcinoma cells, and embryonic stem cells in vitro (Takahashi et al, 1999;Soprano et al, 2007). Recent findings have shown that endogenous RA is involved in neural differentiation in adult hippocampus in vivo (Jacobs et al, 2006;McCaffery et al, 2006).…”
Section: Effects Of Mood Stabilizers On Adp Differentiationmentioning
confidence: 99%