Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Manzano-Moreno, Francisco Javier; Costela‐Ruiz, Víctor J.; García-Recio, Enrique; Olmedo-Gaya, María Victoria; Ruíz, Concepción; Reyes-Botella, Candela

doi:10.3390/ijms222212215

Cited by 40 publications

(33 citation statements)

References 99 publications

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“…Recently, Manzano-Moreno et al [ 20 ] focused their article on the function of cytokines in the diagnosis and prognosis of OSCC saliva, and a revision of this topic was expanded by Ferrari and co-workers [ 52 ]. Here we have summarized some significant studies ( Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview

et al. 2022

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Background: Oral squamous cell carcinoma (OSCC) is one of the most frequent cancers worldwide. Endoscopic methods may be useful in the evaluation of oral injuries even though the diagnostic gold standard is a biopsy. Targeted screenings could be considered the best way to prevent the occurrence of oral cancer. Aimed to elucidate the potential identification of specific biomarkers of OSCC, the use of saliva is convenient and noninvasive. Many studies reported more than a hundred putative saliva biomarkers for OSCC, and proteogenomic approaches were fundamental to disclosing this issue. Methods: Relevant literature published in the last few years was systematically searched on PubMed and we focused on articles about the use and study of salivary biomarkers in the diagnostics of head and neck cancer (n = 110). Thereafter, we performed a selection focusing on diagnosis with salivary proteomics in OSCC (n = 8). Results: Saliva proteomics can be a source of biomarkers for OSCC. We reviewed literature of biomarker proteins in saliva that could also be evaluated as probable targets for non-invasive screening of oral neoplasm such as cytokines, matrix metalloproteinases, and acute-phase response proteins. Conclusions: The measurement of salivary biomarkers is a highly hopeful technique for the diagnosis of OSCC. Proteogenomic approaches could permit an accurate and early diagnosis of OSCC. This review seeks to generate an up-to-date view on translational OSCC issues by raising awareness of researchers, physicians, and surgeons. Renewed clinical studies, which will validate the sensitivity and specificity of salivary biomarkers, are necessary to translate these results into possible strategies for early diagnosis of OSCC, thus improving patient outcomes.

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Section: Resultsmentioning

confidence: 99%

Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview

et al. 2022

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“…Spalt-like transcription factor 4 (SALL4) is a homologous gene of Drosophila Spalt (7)(8)(9). There are four members of this family, namely SALL1, SALL2, SALL3, and SALL4 (10).…”

Section: Original Articlementioning

confidence: 99%

Study on the mechanism of SALL4 down-regulation in promoting the invasion and migration of oral squamous cell carcinoma and influencing the survival and prognosis of patients

Li¹,

Zhang²,

Xu³

et al. 2022

Ann Transl Med

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Background: To investigate the identification of spalt-like transcription factor 4 (SALL4) in oral squamous cell carcinoma (OSCC).Methods: Recombinant cells loaded with miRNA expression cells were used to transform Tca8113 cells. Simple Tca8113 cells were used as the control group. We detected SALL4 messenger RNA (mRNA) before and after transfection by reverse transcription polymerase chain reaction (RT-PCR) and protein immunoblotting (western blot) A and protein expression. A dual luciferase reporter system was used to verify the targeted regulation of SALL4 and identify miRNA-S to test the effect of miRNA related to SALL4 regulation on the invasion and metastatic ability of Tca8113 cells. Results:The expression of SALL4 mRNA in Tca8113 cells was higher than that in the downregulated and control groups, respectively (P<0.05); there was no difference in Tca8113 cells between the upregulated and downregulated groups (P>0.05). Dual luciferase reporter system showed that the identified miRNA was miRNA-S; there were no differences in migration and invasion of Tca8113 cells between the up-and downregulated groups (P>0.05). Conclusions:In human OSCC, SALL4 regulation-related miRNAs are poorly expressed and can inhibit the invasion and metastasis of tumor cells, which is expected to become a new therapeutic target for OSCC.

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“…Oral squamous cell carcinoma (OSCC) is the most common oral malignant tumor, and the 5-year survival rate is only 50% ( 27 ). Due to the lack of symptoms and lack of awareness of risk factors such as smoking and alcohol, the diagnosis is often late.…”

Section: Expression and Role Of Igf2bps In Hnsccmentioning

confidence: 99%

Role of IGF2BPs in head and neck squamous cell carcinoma

Chang²,

Li³

et al. 2022

Front. Oncol.

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IGF2BPs belongs to a family of conserved RNA-bound oncoembryonic proteins that play a crucial part in various aspects of cell function, such as cell migration, morphology, metabolism, proliferation and differentiation. Recent studies have shown that IGF2BPs play a role as a member of m6A reader. m6A is the most abundant modification in RNA epigenetics, which is closely related to a family of RNA-binding proteins. These proteins are fell into three categories—writers, readers and erasers. In the present study, IGF2BPs play an important role in tumor metabolism, especially in head and neck squamous cell carcinoma (HNSCC) metabolism. In this paper, the basic structure of IGF2BPs, its role in the development of HNSCC, molecular mechanism, research progress and research prospect of IGF2BPs in HNSCC are reviewed, which will providing new ideas for further study of IGF2BPs.

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Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Cited by 40 publications

References 99 publications

Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview

Salivary Biomarkers in Oral Squamous Cell Carcinoma: A Proteomic Overview

Study on the mechanism of SALL4 down-regulation in promoting the invasion and migration of oral squamous cell carcinoma and influencing the survival and prognosis of patients

Role of IGF2BPs in head and neck squamous cell carcinoma

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