Role of <scp>HLA</scp>‐<scp>DP</scp> and <scp>HLA</scp>‐<scp>DQ</scp> on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population

Trinks, Julieta; Nishida, Nao; Hulaniuk, María Laura; Caputo, Mariela; Tsuchiura, Takayo; Marciano, Sebastián; Haddad, Leila; Blejer, Jorgelina L.; Bartoli, Sonia; Ameigeiras, Beatriz; Frias, Silvia; Vistarini, Cecilia; Heinrich, Fabiana; Remondegui, Carlos; Ceballos, Susana; Echenique, Gustavo; Samman, Miguel Charre; D'Amico, Claudia; Rojas, Amalia; Martínez, Alfredo P.; Ridruejo, Ezequiel; Fernández, Roberto; Pratx, Leandro Burgos; Salamone, Horacio J.; Núñez, Félix; Galdame, Omar; Gadano, Adrián; Corach, Daniel; Sugiyama, Masaya; Flichman, Diego Martín; Tokunaga, Katsushi; Mizokami, Masashi

doi:10.1111/liv.13405

Cited by 16 publications

(20 citation statements)

References 34 publications

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“…The rs3077‐T allele is the minor allele among individuals with Asian ancestry but is the major allele among those with European ancestry, according to the data of the HapMap project and from the pilot studies of the 1000 Genomes project (https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=3077, assessed on 28 May 2017). This is also in accordance with the findings of numerous studies, including a healthy control group in Asian and in Caucasian populations, and with the allele frequency observed in our HC group (84.3% for the T allele). Our study confirms for the first time the protective role of the rs3077‐T allele, independently of the population origin.…”

Section: Discussionsupporting

confidence: 93%

“…Apart from HBV persistence, we also intended to investigate whether the HLA SNPs are associated with different stages of chronic HBV infection. We found no association with inactive carrier state, HBeAg state or cirrhosis, which is in accordance with other studies on Caucasians, Asians or mixed populations, although in our study the number of cirrhosis cases was quite small. However, a Chinese study has suggested that rs9277534 might be associated with the progression from asymptomatic HBV carriers to HBV‐related cirrhosis .…”

Section: Discussionsupporting

confidence: 93%

“…The differences between the findings of those studies and ours might be due to the different genetic backgrounds on the one hand and the high number of included individuals in our analysis on the other hand. Similar to our study, a study conducted in Argentina supports our findings for the role of the rs3077‐T allele in spontaneous SC in the populations examined . However, the conclusions of this study refer to specific admixed populations residing in the country and cannot be generalized.…”

Section: Discussionsupporting

confidence: 89%

“…Asian ancestry but is the major allele among those with European May 2017). This is also in accordance with the findings of numerous studies, including a healthy control group in Asian 7,8,11,12,17,30 and in Caucasian populations, 23,24,29 and with the allele frequency observed in our HC group (84.3% for the T allele). Our study confirms for the first time the protective role of the rs3077-T allele, independently of the population origin.…”

Section: The Rs3077-t Allele Is the Minor Allele Among Individuals Withsupporting

confidence: 93%

“…Similar to our study, a study conducted in Argentina supports our findings for the role of the rs3077-T allele in spontaneous SC in the populations examined. 29 However, the conclusions of this study refer to specific admixed populations residing in the country and cannot be generalized.…”

Section: Discussionmentioning

confidence: 81%

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Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Koukoulioti

Fischer

Schott

et al. 2019

Liver International

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Background & Aims Acute hepatitis B virus (HBV) infections may clear spontaneously or become chronic and run through different phases. The single nucleotide polymorphisms (SNPs) rs3077, rs9277535 and rs9277534 within the human leucocyte antigen (HLA)‐DP gene have been found to be associated with HBV susceptibility and persistence in Asians. However, evidence for the influence of these variants in Caucasians has been limited so far. The aim of our study was to investigate the impact of these polymorphisms on the outcome of HBV infections in a large Caucasian population. Methods In this case‐control study, we retrospectively analysed 1111 Caucasian individuals, including 618 with chronic HBV infections (CHB), 239 with spontaneous HBsAg seroclearance (SC) and 254 healthy controls (HC). The rs3077, rs9277535 and rs9277534 SNPs were genotyped by a polymerase chain reaction from blood samples and melting curve analysis. Results A significant difference in the allele distributions was observed only for the rs3077 SNP between the HC and the CHB group as well as between the SC and CHB groups. The rs3077‐C allele was associated with a lower probability for spontaneous HBsAg seroclearance in comparison with the rs3077‐T allele (OR 0.704, 95% CI 0.509‐0.974; P = 0.033). No association of the three SNPs with the stages of chronic HBV infection was found. Conclusion This is the first study demonstrating an association of the rs3077‐T allele with spontaneous HBsAg seroclearance in Caucasians. Further studies are needed to elucidate the role of HLA‐DP variants in disease pathogenesis and their potential role for individualized disease management.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Section: The Rs3077-t Allele Is the Minor Allele Among Individuals Withsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 81%

See 3 more Smart Citations

Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Koukoulioti

Fischer

Schott

et al. 2019

Liver International

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Current research status of HLA in immune‐related diseases

Liu

Shao

2021

Immunity Inflam & Disease

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Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas. HLA is divided into class I antigens, class II antigens, and class III antigens according to distribution and function. Classical HLA class I antigens include HLA‐A, HLA‐B, and HLA‐C; HLA class II antigens include HLA‐DP, HLA‐DQ, and HLA‐DR; nonclassical HLA class I and II molecules include HLA‐F, E, H, X, DN, DO, and DM; and others, such as complement, are class III antigens. HLA is closely related to the body's immune response, regulation, and surveillance and is of great significance in the study of autoimmune diseases, tumor immunity, organ transplantation, and reproductive immunity. HLA is an important research topic that bridges immunology and clinical diseases. With the development of research methods and technologies, there will be more discoveries and broader prospects.

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Multiple doses of hepatitis B recombinant vaccine for chronic hepatitis B patients with low surface antigen levels: a pilot study

et al. 2018

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Role of HLA‐DP and HLA‐DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population

Cited by 16 publications

References 34 publications

Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Association of HLA‐DPA1 and HLA‐DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians

Current research status of HLA in immune‐related diseases

Multiple doses of hepatitis B recombinant vaccine for chronic hepatitis B patients with low surface antigen levels: a pilot study

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