Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons

Sapède, Dora; Rossel, Mireille; Dambly‐Chaudière, Christine; Ghysen, Alain

doi:10.1073/pnas.0406382102

Cited by 51 publications

(51 citation statements)

References 23 publications

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“…Recent studies demonstrated that inactivation of CXCL12 and CXCR4 prevents PLL primordium migration, resulting in the formation of defective PLL (David NB et al, 2002;Li Q et al, 2004;Haas P and Gilmour D, 2006). The migration of motor neurons of the facial nucleus from rhombomere 4 to 6 was also affected in CXCL12 morphants (Sapede D et al, 2005). In CXCR4 mutant mice, the number of muscle progenitors that colonized the anlage of the tongue and the dorsal limb was reduced.…”

Section: Others-cxcl12/cxcr4mentioning

confidence: 97%

“…In zebrafish, peripheral sensory efferent projection requires intact CXCL12/CXCR4 signaling (Gilmour D et al, 2004;Sapede D et al, 2005). The peripheral PLL in zebrafish receives axonal afferent inputs from two different efferent nuclei in the hindbrain (Metcalfe WK et al, 1985).…”

Section: Axon Guidance and Pathfindingmentioning

confidence: 99%

“…CXCL12/CXCR4 is involved in the embryonic development of diverse peripheral tissues such as blood vessels, muscle, primordial germ cell (PGC) and sensory lateral line etc (Nagasawa T et al, 1996;Tachibana K et al, 1998;Zhu YR et al, 1998;David NB et al, 2002;Odemis V et al, 2005;Sapede D, 2005;Haas P and Gilmour D 2006). In addition, CXCL12/CXCR4 participates in peripheral pathogenetic processes.…”

Section: Introductionmentioning

confidence: 99%

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Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology

Ransohoff

2008

Progress in Neurobiology

307

245

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Chemotactic cytokines (chemokines) have been traditionally defined as small (10-14 kDa) secreted leukocyte chemoattractants. However, chemokines and their cognate receptors are constitutively expressed in the central nervous system (CNS) where immune activities are under stringent control. Why and how the CNS uses the chemokine system to carry out its complex physiological functions has intrigued neurobiologists. Here, we focus on chemokine CXCL12 and its receptor CXCR4 that have been widely characterized in peripheral tissues and delineate their main functions in the CNS. Extensive evidence supports CXCL12 as a key regulator for early development of the CNS. CXCR4 signaling is required for the migration of neuronal precursors, axon guidance/pathfinding and maintenance of neural progenitor cells (NPCs). In the mature CNS, CXCL12 modulates neurotransmission, neurotoxicity and neuroglial interactions. Thus, chemokines represent an inherent system that helps establish and maintain CNS homeostasis. In addition, growing evidence implicates altered expression of CXCL12 and CXCR4 in the pathogenesis of CNS disorders such as HIVassociated encephalopathy, brain tumor, stroke and multiple sclerosis (MS), making them the plausible targets for future pharmacological intervention.

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Section: Others-cxcl12/cxcr4mentioning

confidence: 97%

Section: Axon Guidance and Pathfindingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology

Ransohoff

2008

Progress in Neurobiology

307

245

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“…The 26-1 mutation is in neither of these genes. Although chemokines and their receptors have been shown to direct cell migration in the nervous system (Bagri et al, 2002;Lu et al, 2002;Stumm et al, 2003;Belmadani et al, 2005;Knaut et al, 2005;Miller and Tran, 2005;Sapede et al, 2005), so far none has been shown to affect telencephalic patterning. Nonetheless, it is attractive to speculate that 26-1 affects a gene with a key role in directing motor axon outgrowth by affecting the SDF1(Cxcl12)-Cxcr4 signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

A Genetic Screen for Mutations That Affect Cranial Nerve Development in the Mouse

Mar

Rivkin²,

Kim³

et al. 2005

J. Neurosci.

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Cranial motor and sensory nerves arise stereotypically in the embryonic hindbrain, act as sensitive indicators of general and regionspecific neuronal development, and are directly or indirectly affected in many human disorders, particularly craniofacial syndromes. The molecular genetic hierarchies that regulate cranial nerve development are mostly unknown. Here, we describe the first mouse genetic screen that has used direct immunohistochemical visualization methods to systematically identify genetic loci required for cranial nerve development. After screening 40 pedigrees, we recovered seven new neurodevelopmental mutations. Two mutations model human genetic syndromes. Mutation 7-1 causes facial nerve anomalies and a reduced lower jaw, and is located in a region of conserved synteny with an interval associated with the micrognathia and mental retardation of human cri-du-chat syndrome. Mutation 22-1 is in the Pax3 gene and, thus, models human Waardenburg syndrome. Three mutations cause global axon guidance deficits: one interferes with initial motor axon extension from the neural tube, another causes overall axon defasciculation, and the third affects general choice point selection. Another two mutations affect the oculomotor nerve specifically. Oculomotor nerve development, which is disrupted by six mutations, appears particularly sensitive to genetic perturbations. Phenotypic comparisons of these mutants identifies a "transition zone" that oculomotor axons enter after initial outgrowth and in which new factors govern additional progress. The number of interesting neurodevelopmental mutants revealed by this small-scale screen underscores the promise of similar focused genetic screens to contribute significantly to our understanding of cranial nerve development and human craniofacial syndromes.

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“…Furthermore, Hedgehog proteins are modified by cholesterol (for a review, see Bürglin, 2008;Porter et al, 1996). It is also likely that the disruption of other heterotrimeric G-protein-dependent signaling pathways, including Sdf1 (Cxcl12)/Cxcr4 (Sapède et al, 2005;Cubedo et al, 2009), contributes to FBMN migration defects in Pggt1b-deficient embryos. Finally, the disrupted geranylgeranylation of small GTPases might cause cytoskeletal disorganization and further impair migration.…”

Section: Discussionmentioning

confidence: 99%

Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity

et al. 2011

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SUMMARYThe facial branchiomotor neurons (FBMNs) undergo a characteristic tangential migration in the vertebrate hindbrain. We previously used a morpholino knockdown approach to reveal that zebrafish prickle1b (pk1b) is required for this migration. Here we report that FBMN migration is also blocked in a pk1b mutant with a disruption in the consensus farnesylation motif. We confirmed that this lipid modification is required during FBMN migration by disrupting the function of farnesyl biosynthetic enzymes. Furthermore, farnesylation of a tagged Pk1b is required for its nuclear localization. Using a unique rescue approach, we have demonstrated that Pk1b nuclear localization and farnesylation are required during FBMN migration. Our data suggest that Pk1b acts at least partially independently of core planar cell polarity molecules at the plasma membrane, and might instead be acting at the nucleus. We also found that the neuronal transcriptional silencer REST is necessary for FBMN migration, and we provide evidence that interaction between Pk1b and REST is required during this process. Finally, we demonstrate that REST protein, which is normally localized in the nuclei of migrating FBMNs, is depleted from the nuclei of Pk1b-deficient neurons. We conclude that farnesylation-dependent nuclear localization of Pk1b is required to regulate REST localization and thus FBMN migration.

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Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons

Cited by 51 publications

References 23 publications

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology

Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology

A Genetic Screen for Mutations That Affect Cranial Nerve Development in the Mouse

Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity

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