Role of seminal prostaglandins in male fertility. II. Effects of prostaglandin synthesis inhibition on spermatogenesis in man

Abstract

The effect of prostaglandin biosynthesis inhibition has been studied in two groups of infertile oligozoospermic patients with high or normal-low seminal prostaglandin (PG) levels. PGE and 19-OH PGE were assayed by means of a gas chromatographic method and the most important seminal parameters (volume, concentration, motility and morphology of spermatozoa) were evaluated in basal conditions and at the end of indomethacin treatment, at a daily oral dose of 100 mg for thirty days. A drop in prostaglandin levels following indomethacin was observed in both groups of patients but only in the group with high concentrations of prostanoid derivates the prostaglandin inhibition was correlated with a significant improvement in sperm count and motility.

Effect of Diclofenac Sodium (Voltaren) on Spermatogenesis of Infertile Oligospermic Patients

“…Our data are in agreement with previous investiga tions [6,8], where high levels of prostaglandins were…”

Arachidonic Acid Pathways and Male Fertility: A Systematic Review

“…Interestingly, Conte et al, showed that indomethacin improved significantly the sperm count and motility in infertile oligozoospermic patients with high levels of PGs [86]. The number of pregnancies was reduced in the groups mated with indomethacin and oxyphenbutazone treated male rats [87].…”

Effects of clinical medications on male fertility and prospects for stem cell therapy

“…Many clinical studies have shown that indomethacin can improve sperm production in patients with oligo asthenoter atozoospermia, increase sperm motility and sperm count, and enhance fertilization ability. However, it can decrease testosterone levels ( Aydin et al, 1995 ; Barkay et al, 1984 ; Conte et al, 1985 ; Guo et al, 2015 ). In studies on the effect of sodium ions on sperm motility, amiloride was found to increase the acrosome reaction and decrease sodium-induced sperm motility ( Peris et al, 2000 ; Rai and Nirmal., 2003 ; Wong et al, 1981 ).…”