Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice

Harasawa, Toshiya; Ago, Yukio; Itoh, Soichi; Baba, Akemichi; Matsuda, Takehisa

doi:10.1097/01.fbp.0000236266.34182.1c

Cited by 21 publications

(19 citation statements)

References 24 publications

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“…The number of marbles that have been buried is then counted by an observer, who is often blind to the treatment status of the subjects (Angoa-Pérez et al, 2013;Egashira et al, 2018;Millan et al, 2002). Importantly, since the majority of investigations do not distinguish between the specific behavioral patterns resulting in marbles being lowered into the burying substrate Gaikwad & Parle, 2011;Gomes, Casarotto, Resstel, & Guimarães, 2011;Harasawa, Ago, Itoh, Baba, & Matsuda, 2006;Honda, Kawaura, Soeda, Shirasaki, & Takahama, 2011;Li et al, 2006;Matsushima, Shirota, Kikura-Hanajiri, Goda, & Eguchi, 2009;Shimazaki, Iijima, & Chaki, 2004;Umathe et al, 2012;Yamada et al, 2002), the term Bburied^is generally applied to indicate the number of covered marbles. Although the reported methodologies always refer to the duration of exposure as well as the number of marbles and the burying substrate used, several experimental variables are subject to modification, either intentionally or not.…”

Section: A Methodological Review Of the Mbtmentioning

confidence: 99%

“…1a; Angoa-Pérez et al, 2013;Jimenez-Gomez et al, 2011;Thomas et al, 2009), sawdust (Supplementary Fig. 1b;Bruins Slot et al, 2008;Dixit et al, 2014;Harasawa et al, 2006;Krass, Rünkorg, Wegener, & Volke, 2010), wood chips (Supplementary Fig. 1c; Llaneza & Frye, 2009;Londei et al, 1998;Saadat, Elliott, Colado, & Gree, 2006;Thomas et al, 2009), wood shavings (Supplementary Fig.…”

Section: Burying Substrate and Its Relation To Marble Sizementioning

confidence: 99%

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A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

Brouwer

Fick

Harvey

et al. 2018

Cogn Affect Behav Neurosci

125

111

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Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety-and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds variably to a range of pharmacological interventions, and little consensus exists regarding specific methodologies for its execution. Regardless, the test is widely applied to investigate the effects of pharmacological, genetic, and behavioral manipulations on purported behaviors related to the said neuropsychiatric constructs. Therefore, in the present review we attempt to expound the collective translational significance of the MBT. We do this by (1) reviewing burying behavior as a natural behavioral phenotype, (2) highlighting key aspects of anxiety and obsessive-compulsive disorder from a translational perspective, (3) reviewing the history and proof of concept of the MBT, (4) critically appraising potential methodological confounds in execution of the MBT, and (5) dissecting responses of the MBT to various pharmacological interventions. We conclude by underlining that the collective translational value of the MBT will be strengthened by contextually valid experimental designs and objective reporting of data.

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Section: A Methodological Review Of the Mbtmentioning

confidence: 99%

Section: Burying Substrate and Its Relation To Marble Sizementioning

confidence: 99%

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

Brouwer

Fick

Harvey

et al. 2018

Cogn Affect Behav Neurosci

125

111

View full text Add to dashboard Cite

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“…12,63,64) Furthermore, it inhibited aggressive [65][66][67] and obsessive-compulsive 68) behaviors. These results support the idea that the 5-HT 1A receptor is a potential target for the treatment of psychiatric disorders.…”

Section: )mentioning

confidence: 99%

Neuropharmacologic Studies on the Brain Serotonin<sub>1A</sub> Receptor Using the Selective Agonist Osemozotan

Matsuda

2013

Biological & Pharmaceutical Bulletin

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Alterations in serotonin (5-HT) neurochemistry have been implicated in the etiology of major neuropsychiatric disorders such as anxiety-spectrum disorders, depression, and schizophrenia. The neuromodulatory effects of 5-HT are mediated through 14 receptor subtypes, and those receptors, including the 5-HT 1A receptor, are considered to be potential targets for the treatment of psychiatric disorders. We developed the novel 5-HT 1A receptor agonist MKC-242 (called osemozotan) and characterized its neurochemical and pharmacological profiles. 5-HT 1A receptor agonists modulate the release of amine neurotransmitters through the activation of presynaptic or postsynaptic 5-HT 1A receptors in the brain. The agonist has antianxiety and antidepressant effects and improves abnormal behaviors such as aggressive behavior and deficits of prepulse inhibition in isolation-reared mice. We also demonstrated that spinal 5-HT 1A receptor activation is involved in isolation rearing-induced hypoalgesia. Concerning the mechanism for induction of isolation-induced abnormal behaviors, we have recently found that the raphe-prefrontal 5-HT system plays a key role in encounter stimulation-induced hyperactivity in isolation-reared mice. Furthermore, we showed that osemozotan attenuates psychostimulant-induced behavioral sensitization and that prefrontal dopamine release is enhanced by functional interaction between the 5-HT 1A receptor and other receptors. This review summarizes the neuropharmacology of the 5-HT 1A receptor, focusing on our studies using osemozotan, and suggests that the 5-HT 1A receptor may be a target molecule for the treatment of psychiatric disorders, pain, and drug dependence.

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“…The pharmacological profile of mirtazapine is characterized by a potent antago- nism of presynaptic α 2 -adrenergic receptors on both noradrenaline and 5-HT neurons and by a potent antagonism of postsynaptic 5-HT 2 and 5-HT 3 but not 5-HT 1A receptors. It has been reported that the effect of fluvoxamine on marble-burying behavior is attenuated by the selective 5-HT 1A receptor antagonist WAY100635 at 1 mg/kg, while it is enhanced by WAY100635 at 0.1 mg/kg (13), suggesting that the involvement of 5-HT 1A receptors. Therefore, the effect of mirtazapine might be mediated, in part, by 5-HT 1A receptors.…”

mentioning

confidence: 99%

“…Indeed, SSRIs such as fluvoxamine and paroxetine, which are used to treat human OCD symptoms (3), inhibit marble-burying behavior without affecting locomotor activity in mice (12,13). Moreover, uncompetitive NMDA-receptor antagonists such as memantine and amantadine inhibit marble-burying behavior without affecting locomotor activity (14).…”

mentioning

confidence: 99%

<I>N</I>-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

et al. 2012

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Abstract. In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.

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Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice

Cited by 21 publications

References 24 publications

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward

Neuropharmacologic Studies on the Brain Serotonin<sub>1A</sub> Receptor Using the Selective Agonist Osemozotan

<I>N</I>-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

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