Role of serum C-reactive protein (CRP)/Albumin ratio in predicting the severity of acute pancreatitis: A retrospective cohort

Kazmi, Syed Jawad Haider; Zafar, Muhammad Talha; Zia, Beenish Fatima; Khalid, Saleha Rashid; Kumar, Vikesh; Tabassum, Shaesta; Ahmed, Ali; Aziz, Nouman; Khan, Noman; Kumari, Kanchan; Saleem, Kanza; Asghar, Muhammad Sohaib

doi:10.1016/j.amsu.2022.104715

Cited by 7 publications

(7 citation statements)

References 24 publications

(25 reference statements)

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“…A subset of 216 patients had two consecutive FC levels available, separated by 13 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) months. The percentage change in FC was associated (all P ≤ 0.0001) with albumin (r = À0.26), CRP (r = 0.28), and CAR (r = 0.26) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In other inflammatory diseases, combining CRP and albumin as a CRP‐to‐albumin ratio (CAR) has improved the performance of either used alone; for example, CAR was a superior predictor of 90‐day mortality compared with albumin or CRP in patients with sepsis. 16 , 17 , 18 Its application in patients with IBD is limited to its ability to predict symptomatic disease and mucosal healing in Crohn's disease 1 , 10 , 19 and its prognostic value in patients with acute severe UC. 20 , 21 Its relationship to objective inflammatory disease and in the detection of subtherapeutic infliximab levels has not been reported.…”

Section: Introductionmentioning

confidence: 99%

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Clinical utility of C‐reactive protein‐to‐albumin ratio in the management of patients with inflammatory bowel disease

Nguyen,

Brick,

Liu

et al. 2024

JGH Open

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Background and AimC‐reactive protein (CRP)‐to‐albumin ratio (CAR) is a novel score with prognostic value in inflammatory conditions. This study assessed the performance of CAR as an objective marker of disease activity and prediction of subtherapeutic infliximab trough levels in patients with inflammatory bowel disease (IBD).MethodsA retrospective study was conducted on three different patient cohorts with IBD: patients who had (i) fecal calprotectin (FC) measurements; (ii) Mayo Endoscopic Scores; and (iii) infliximab trough levels available. The relative performances of CAR, albumin, and CRP were compared in predicting disease activity (based on FC or Mayo Endoscopic Score) and infliximab trough levels.ResultsIn both the FC (n = 289) and endoscopy (n = 65) cohorts, albumin and CAR correlated with objective disease activity. CAR (area under the curve [AUC] 0.70) was only marginally better at detecting active disease, measured by FC, compared to CRP (AUC 0.68). A CAR >0.15 was able to detect Mayo 3 disease (AUC 0.83, sensitivity 81%, specificity 89%). Albumin (r = 0.38) and CAR (r = −0.42) correlated with infliximab trough levels (n = 204). The optimal CAR for detecting subtherapeutic infliximab trough levels was >0.08 (AUC 0.70, sensitivity 66%, specificity 64%). Both albumin and CAR were independent predictors of subtherapeutic infliximab trough levels but correlated poorly with infliximab trough levels longitudinally in the same patient.ConclusionCAR was only a modest discriminator of subtherapeutic infliximab levels and offers little more than CRP in detecting active disease. CAR has potential to detect severe Mayo 3 disease and could be calculated in patients admitted with suspected acute severe ulcerative colitis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical utility of C‐reactive protein‐to‐albumin ratio in the management of patients with inflammatory bowel disease

Nguyen,

Brick,

Liu

et al. 2024

JGH Open

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“…When the body is exposed to inflammatory stimuli or bacterial infections, the CRP level rises after 4–6 h of activation and increases approximately 1-fold every 8 h, usually peaking at 36–50 h [ 3 ]. With the recovery of inflammation, the CRP level declines explosively over 18 to 20 h, approaching the half-life of CRP [ 4 ]. It is well-established that CRP concentrations in the body is intimately correlated with heart-related diseases [ 5 , 6 ], cardiovascular diseases [ 7 , 8 ], rheumatoid arthritis [ 9 ], cancer [ 10 , 11 ], and inflammation [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Simple Label-Free Aptamer-Based Electrochemical Biosensor for the Sensitive Detection of C-Reactive Proteins

Gao

Bai

et al. 2022

Biosensors

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The level of C-reactive protein (CRP) in the human body is closely associated with cardiovascular diseases and inflammation. In this study, a label-free functionalized aptamer sensor was attached to an electrode trimmed with in-gold nanoparticles and carboxylated graphene oxide (AuNPs/GO-COOH) to achieve sensitive measurements relative to CRP. Gold nanoparticles were selected for this study due to super stability, remarkably high electrical conductivity, and biocompatibility. In addition, carboxylated graphene oxide was utilized to promote the anchorage of inducer molecules and to increase detection accuracies. The sensing signal was recorded using differential pulse voltammetry (DPV), and it produced a conspicuous peak current obtained at approximately −0.4 V. Furthermore, the adapted sensor manifested a broad linear span from 0.001 ng/mL to 100 ng/mL. The results also demonstrated that this aptamer sensor had superior stability, specificity, and reproducibility. This aptamer-based electrochemical sensor has enormous potential in complex application situations with interfering substances.

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“…13 A recent study reported that a CRP/albumin ratio greater than 4.35 had has higher sensitivity and negative predictive value to predict severe pancreatitis than the CRP level alone. 14 Information regarding the role of CRP in pediatric pancreatitis patients is limited. Therefore, this study aimed to evaluate the clinical characteristics of AP and the potential of CRP as a marker to determine the severity of AP in children.…”

mentioning

confidence: 99%

“…The maximum CRP level can also be a predictive factor for the onset of necrosis 13 . A recent study reported that a CRP/albumin ratio greater than 4.35 had has higher sensitivity and negative predictive value to predict severe pancreatitis than the CRP level alone 14 . Information regarding the role of CRP in pediatric pancreatitis patients is limited.…”

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confidence: 99%

Potential Predictors of Severe and Recurrent Pancreatitis in Children

Kim

2023

Pediatr Emer Care

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Objectives Severe pancreatitis often requires intensive care; therefore, early detection is important. This study aimed to evaluate the possible predictors of pancreatitis severity in children. Furthermore, we evaluated the prevalence of pancreatitis recurrence and related factors. Methods We retrospectively analyzed the medical records of patients aged younger than 18 years who were diagnosed with acute pancreatitis between January 2017 and June 2022. Acute pancreatitis was diagnosed and classified based on the revised Atlanta criteria. Results A total of 64 patients were enrolled, and severe pancreatitis was observed in 10 (15.6%) patients. Patients with severe pancreatitis were younger and had higher C-reactive protein levels than those with mild pancreatitis. The areas under the receiver operating characteristic curves of C-reactive protein levels at admission and 48 hours after diagnosis were 0.612 (95% confidence interval, 0.379–0.844) and 0.873 (95% confidence interval, 0.537–0.983), respectively. Fourteen patients (21.9%) experienced further episodes of recurrent pancreatitis. Patients with recurrent pancreatitis were older (13.7 vs 11.4 years, P = 0.022) and prominently boys (85.7 vs 52%, P = 0.022) compared with those without recurrence. Obesity was observed in 4 (0.6%) patients, which was confirmed in all recurrence groups and was statistically significant. Conclusions This study demonstrated the feasibility of C-reactive protein in the early risk assessment of patients with acute pancreatitis and highlighted the potential risk of recurrence in patients with obesity.

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Role of serum C-reactive protein (CRP)/Albumin ratio in predicting the severity of acute pancreatitis: A retrospective cohort

Cited by 7 publications

References 24 publications

Clinical utility of C‐reactive protein‐to‐albumin ratio in the management of patients with inflammatory bowel disease

Clinical utility of C‐reactive protein‐to‐albumin ratio in the management of patients with inflammatory bowel disease

A Simple Label-Free Aptamer-Based Electrochemical Biosensor for the Sensitive Detection of C-Reactive Proteins

Potential Predictors of Severe and Recurrent Pancreatitis in Children

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