Role of serum immunoglobulins in patients of oral lichen planus and oral lichenoid reaction

Abstract

The aim of the study is to find out the role of immunoglobulin IgA and IgM as indicators of humoral immune response in the etiopathogenesis and for the differentiation between oral lichen planus (OLP) and oral lichenoid reaction (OLR). The study comprises of 50 patients. From them 20 patients were of OLP, 20 patients of OLR and 10 patients as controls. After histopathological confirmation, approximately 5 ml of venous blood was collected by venepuncture from OLP patients, OLR patients and from control patients. The serum IgA and IgM were measured by immunoturbidimetry method using automated chemistry analyzer and data were analysed using t-test. The mean serum level of IgA and IgM was 2.14±1.19g/L and 0.88±0.47g/L respectively in reticular OLP, 2.21±0.98g/L and 0.78±0.49g/L respectively in erosive OLP, 1.64±0.60g/L and 0.99±0.34g/L respectively in OLR, 2.62±0.40g/L and 1.51±0.47g/L respectively in control patients. The results showed statistically significant IgM level for reticular and erosive OLP (p value=0.007 and 0.042 respectively). Patients with OLP shows systemic immunologic alterations suggest that humoral immune system may play a part in pathogenesis of OLP and also OLP and OLR lesions can be differentiate on the basis of serum level of IgM.

Measurement of some immunological Indicators in patients with recurrent oral lichen planus and some viral infections

“…The work reported by [13]who indicated that roughly 0.5 -4% of the general population has OLP. The condition occurs at all ages, peaking at the age of 40 It is more prevalent in women than in men, with a male to female ratio of 1:1.8 [14] showed an increased IgA and IgM mean serum levels were 2.49 g/L and 1.32 g/L in men and 1.98 g/L and 0.68 g/L in females, respectively, out of patients with reticular lichen planus. Thus, the results indicate that the mean serum IgA and IgM level were decreased in females compared to males in reticular OLP but the mean serum IgA level was slightly decreased and IgM was significantly increased in females compared to males in erosive OLP.…”