2019
DOI: 10.1128/iai.00889-18
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Role of Sialic Acid in Brachyspira hyodysenteriae Adhesion to Pig Colonic Mucins

Abstract: Infection with Brachyspira hyodysenteriae results in mucoid hemorrhagic diarrhea. This pathogen is associated with the colonic mucus layer, mainly composed of mucins. Infection regulates mucin O-glycosylation in the colon and increases mucin secretion as well as B. hyodysenteriae binding sites on mucins. Here, we analyzed potential mucin epitopes for B. hyodysenteriae adhesion in the colon, as well as the effect of colonic mucins on bacterial growth. Associations between B. hyodysenteriae binding to pig coloni… Show more

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Cited by 19 publications
(22 citation statements)
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“…In a healthy pig, the colon is dominated by sulfomucins, but pigs clinically affected with swine dysentery have a marked increase in sialomucins [ 35 ]. Further, B. hyodysenteriae demonstrates chemotaxis toward sialated mucins [ 9 ], thus it is plausible differences in production of sialic acid alter susceptibility to B. hyodysenteriae challenge. Rats fed diets containing highly fermentable inulin had a predominance of sulfomucins in the colon, while those on a standard commercial diet had a greater proportion of sialomucins [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
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“…In a healthy pig, the colon is dominated by sulfomucins, but pigs clinically affected with swine dysentery have a marked increase in sialomucins [ 35 ]. Further, B. hyodysenteriae demonstrates chemotaxis toward sialated mucins [ 9 ], thus it is plausible differences in production of sialic acid alter susceptibility to B. hyodysenteriae challenge. Rats fed diets containing highly fermentable inulin had a predominance of sulfomucins in the colon, while those on a standard commercial diet had a greater proportion of sialomucins [ 36 ].…”
Section: Discussionmentioning
confidence: 99%
“…Dietary fiber increases mucus production and may alter mucin composition [ 7 , 8 ], which could increase susceptibility to B. hyodysenteriae challenge, as these components are chemoattractants for B. hyodysenteriae . In particular, B. hyodysenteriae is attracted to sialic acid residues on acidic mucins, which are highly abundant in pigs with clinical swine dysentery [ 9 ]. However, it is unclear whether dietary fiber increases sialic acid mucin production, and whether that allows for greater B. hyodysenteriae colonization.…”
Section: Introductionmentioning
confidence: 99%
“…Mucin glycosylation can govern bacterial adhesion, virulence and growth [ 22 , 25 , 26 , 30 , 31 , 50 , 51 , 52 ], and glycosylation changes modulate host-bacterial interactions [ 23 , 25 ]. Consequently, the stress-induced glycosylation changes have the potential to affect the sensitivity towards infection, as well as the normal microbiota.…”
Section: Discussionmentioning
confidence: 99%
“…Among the glycosylation changes identified, the increased proportion of large glycan structures suggests a decreased mucin production [ 46 ], which may contribute to the increased susceptibility to disease of stressed fish. The structural changes also have potential to affect host pathogen interactions [ 22 , 25 , 26 , 31 , 32 , 52 ]. Finally, the relative abundance of O -glycan structures Galß1-3(NeuAcα2-6)GalNacol, NeuAcα2-3Galß1-3(NeuAcα2-6)GalNAcol and core type 1 structures as well as the proportion of sialylation in the form of NeuAcα2-3 has potential as biomarkers for stress in fish, especially for the accumulative chronic and AS, as this was not apparent in any of the other stress markers.…”
Section: Discussionmentioning
confidence: 99%
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