Role of sodium thiosulfate therapy in the treatment of digital necrosis due to Mönckeberg sclerosis

Abstract

Accelerated vascular calcification is a well-described complication of chronic kidney disease often affecting large and small vessels alike through a variety of mechanisms. Accordingly, dysregulation of calcium and phosphate balance, vitamin D metabolism, hyperparathyroidism, and endothelial injury can lead to both macrovascular and microvascular complications. We describe a 56-year-old Hispanic male with a history of end-stage renal disease, diabetes mellitus type 2, and medical noncompliance who developed sequential digital ischemia and necrosis involving both hands as well as right foot as a result of Mönckeberg sclerosis. An extensive metabolic and serologic workup was unrevealing but radiographic studies and histopathology revealed the diagnosis. A multifaceted approach was instituted including wound debridement and amputations along with intensive medical support. In addition to improving hypertensive control and striving for improved calcium and phosphate balance, sodium thiosulfate solution was administered for more than 1 year. This aggressive approach allowed his wounds to heal and has arrested further digital ischemia from occurring.

Alternate release of different target species based on the same gold nanorods and monitored by cell imaging

“…Na2S2O3 has been found to leach Au or Ag from ores and can react with gold nanoparticles to form soluble complex compounds [35,36]. Oral Na2S2O3 is usually as maintenance therapy for calcific uremic arteriolopathy, calciphylaxis in clinical practice [37,38]. In addition, there has been growing interest in the initiation of intravenous Na2S2O3 as an adjunctive treatment in nonuremic patients with refractory calciphylactic ulcers [39].…”