Role of sphingolipids in oestrogen signalling in breast cancer cells: an update

Abstract

The signaling pathways activated by the steroid hormone oestrogen include a variety of cytoplasmic second messengers linked to a multitude of tissue-specific effects. In the last decade, sphingolipids and their membrane receptors were added to the list of oestrogenactivated mediators. Oestrogen triggers the sphingolipid signalling cascade in various tissues including breast cancer. Extensive research has shown that sphingolipids are the key regulatory molecules in growth factor networks. Sphingolipids can control the rate of cell proliferation and the differentiation outcome during malignant transformation. In this study, we summarise novel experimental evidences linking sphingolipids to oestrogenactivated effects, highlight the role of sphingolipids in cancer cells and discuss new avenues for future research at the intersection between oestrogen and sphingolipid signalling.

Integrating splice-isoform expression into genome-scale models characterizes breast cancer metabolism

“…The prediction of starch and sucrose metabolism confirms previous genome-wide association studies, which reported significant relation between altered starch and sucrose pathway and the risk of developing ER-negative breast cancer [47]. Sphingolipids are responsible for oestrogen signaling and can control differentiation and proliferation of breast cancer cells [48]. The glycerophospholipid pathway, also flagged as biomarker by GEMsplice, was previously found altered in the metabolic phenotype of breast [49].…”

Natural Grape Extracts Regulate Colon Cancer Cells Malignancy

“…Dietary agents also synergize with chemotherapeutic drugs, thereby reducing the dose of treatment and their whole body toxicity (6)(7)(8)(9). Several dietary compounds such as curcumin (6), genistein (10), dietary isothiocyanates (11), silibinin (8), and the grape fruit contained polyphenol resveratrol (7,(12)(13)(14)(15)(16)(17)(18)(19) have been shown to block the cell cycle in tumoral cells, counteracting the dysregulation of proliferation that is a hallmark in all types of cancer.…”

Blood bioactive sphingolipids in patients with advanced serous epithelial ovarian cancer – mass spectrometry analysis

“…There is substantial evidence obtained in human and animal studies indicating that certain bioactive sphingolipids are involved in development and progression of cancer [7][8][9][10][11][12]. Sphingolipids are a group of lipids containing an organic aliphatic amino alcohol sphingosine backbone or a substance structurally similar to it.…”