Role of spontaneous physical activity in prediction of susceptibility to activity based anorexia in male and female rats

Perez‐Leighton, Claudio E.; Grace, Martha K.; Billington, Charles J.; Kotz, Catherine M.

doi:10.1016/j.physbeh.2014.06.001

Cited by 16 publications

(15 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This model showed that HA rats were more resistant to obesity induced by HF diet compared to LA rats [51], which is direct support for the hypothesis that individual variation in SPA has a noticeable effect on diet-induced obesity. The HA/LA rats illustrate the inter-individual variability in SPA within a particular rodent strain, which has been observed in other rodent strains and related to variability in response to metabolic challenges [52, 53]. For example, recently, work in Balb/c mice fed cafeteria diet showed that obesity-resistant mice increase their SPA (locomotor activity) in response to CAF diet, yet there were no differences in their SPA prior to CAF diet feeding [54].…”

Section: Animal Models Of Spa and Obesitymentioning

confidence: 99%

Spontaneous Physical Activity Defends Against Obesity

et al. 2017

Self Cite

View full text Add to dashboard Cite

Spontaneous physical activity (SPA) is physical activity not motivated by a rewarding goal, such as that associated with food-seeking or wheel running behavior. SPA is often thought of as only “fidgeting”, but that is a mischaracterization, since fidgety behavior can be linked to stereotypies in neurodegenerative disease and other movement disorders. Instead, SPA should be thought of as all physical activity behavior that emanates from an unconscious drive for movement. An example of this may be restless behavior, which can include fidgeting and gesticulating, frequent sit-to-stand movement, and more time spent standing and moving. All physical activity burns calories, and as such, SPA could be manipulated as a means to burn calories, defend against weight gain and reduce excess adiposity. In this review, we discuss human and animal literature on the use of SPA in reducing weight gain, the neuromodulators that could be targeted to this end, and future directions in this field.

show abstract

Section: Animal Models Of Spa and Obesitymentioning

confidence: 99%

Spontaneous Physical Activity Defends Against Obesity

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Notably, the amount of time of rodents spend engaged in spontaneous activity within their home cage is a strong predictor of later adiposity and weight gain. [57][58][59] Physical inactivity has risen to be the leading cause of many chronic, non-communicable diseases. [60][61][62][63][64][65][66][67] A few examples of the 35 chronic conditions linked with physical inactivity include obesity, other metabolic disorders (including T2DM), coronary heart disease, other cardiovascular disorders (hypertension, stroke, and congestive heart failure), depression, anxiety, cognitive dysfunction, osteoporosis and cancer.…”

Section: Introductionmentioning

confidence: 99%

Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity

Johnson

Painter

Javurek

et al. 2015

J Dev Orig Health Dis

View full text Add to dashboard Cite

Endocrine disrupting chemicals (EDC) have received considerable attention as potential obesogens. Past studies examining obesogenic potential of one widespread EDC, bisphenol A (BPA), have generally focused on metabolic and adipose tissue effects. However, physical inactivity has been proposed to be a leading cause of obesity. A paucity of studies has considered whether EDC, including BPA, affects this behavior. To test whether early exposure to BPA and ethinyl estradiol (EE, estrogen present in birth control pills) results in metabolic and such behavioral disruptions, California mice developmentally exposed to BPA and EE were tested as adults for energy expenditure (indirect calorimetry), body composition (echoMRI) and physical activity (measured by beam breaks and voluntary wheel running). Serum glucose and metabolic hormones were measured. No differences in body weight or food consumption were detected. BPA-exposed females exhibited greater variation in weight than females in control and EE groups. During the dark and light cycles, BPA females exhibited a higher average respiratory quotient than control females, indicative of metabolizing carbohydrates rather than fats. Various assessments of voluntary physical activity in the home cage confirmed that during the dark cycle, BPA and EE-exposed females were significantly less active in this setting than control females. Similar effects were not observed in BPA or EE-exposed males. No significant differences were detected in serum glucose, insulin, adiponectin and leptin concentrations. Results suggest that females developmentally exposed to BPA exhibit decreased motivation to engage in voluntary physical activity and altered metabolism of carbohydrates v. fats, which could have important health implications.

show abstract

“…Classified as spontaneous physical activity, locomotor behavior is a key element in the daily lives of animals, required for survival and homeostasis 8 . In recent decades, the development of analytical methods to analyze displacement by videogrammetry has been used in studies with different objectives: to understand the effects of psychostimulants 9 , different environments 10 , food restriction 11 , different conditions of housing 12 , and drugs 13 .…”

Section: Introductionmentioning

confidence: 99%

Accuracy and reliability of a videogrammetry system in the analysis of displacement of Wistar rats

Silva

Santiago

Curiacos

et al. 2017

Motriz: rev. educ. fis.

View full text Add to dashboard Cite

-Aims:The behavior of laboratory animals has been studied through displacement, with different objectives by researchers. Methods: Although different methods have already been used in the tracking of laboratory animals, manual tracking mode videogrammetry for 2D analysis of displacement has not been observed in animal studies. The aim of this study was to verify the accuracy and reliability of determining the displacement of Wistar rats by means of videogrammetry software Dvideo. The accuracy (between the known distance and distance traced) was determined by 3 different evaluators twice consecutive, by videoing a course of 10 meters in the enriched environment together with further analysis of the displacement of the midpoint marked on an apparatus. To calculate reliability (accuracy of the measurement system) and reproducibility (precision of the evaluators) to obtain the ratio of precision to tolerance (P/T), eight animals were filmed for 10 minutes in the enriched environment and analysis of distance covered by one of the animals by three different reviewers thrice consecutive. Results: The results obtained in the course of 10 meters of the known distance demonstrated accuracy of 0.10 m, precision of 0.05 m, and bias of 0.07 m. In the reliability test during the 10 minutes of displacement (m) of animal, the ratio of precision to tolerance (P/T) = 0.1 m was found between three different evaluators, demonstrating adequate capacity of the measure. Conclusion: The manual tracking mode of the Dvideo presented high reliability and it can be employed for the displacement analysis of studies with rat experimental models.

show abstract

Role of spontaneous physical activity in prediction of susceptibility to activity based anorexia in male and female rats

Cited by 16 publications

References 71 publications

Spontaneous Physical Activity Defends Against Obesity

Spontaneous Physical Activity Defends Against Obesity

Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity

Accuracy and reliability of a videogrammetry system in the analysis of displacement of Wistar rats

Contact Info

Product

Resources

About