Role of stem cells in large bowel carcinogenesis

Нефёдова, Н. А.; Мальков, П.Г.

doi:10.17650/2220-3478-2015-5-3-15-24

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…[ 28 ] This influence of PC is mediated by such factors as Wnt‐ligands (Wnt3, Wnt6 and Wnt9b), Notch ligands (Dll‐1 and Dll‐4), as well as epidermal (EGF) and α‐transforming (TGF‐α) growth factors. [ 4,12–20,22–25,27,28,30–60 ] PC affect +LGR5‐cells predominantly through the Wnt signaling pathway. [ 14 ] Wnt proteins are membrane‐bound ligands that are necessary for cell development, migration, and polarization.…”

Section: Location Morphology and Function Of Paneth Cellsmentioning

confidence: 99%

“…[ 6 ] In addition, PC secrete Notch ligands on their membranes, such as Dll1 and Dll4, which bind the Notch receptors on intestinal stem cells, that leads to an increase in the number of stem cells. [ 2,4–20,22–25,27,28,30–59,61–65 ] Recent studies have shown that there is also a metabolic interdependence between PC and stem cells. [ 7 ] Therefore, remarkably, stem cells receive signals that regulate their activity from their descendants—PC.…”

Section: Location Morphology and Function Of Paneth Cellsmentioning

confidence: 99%

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Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer

et al. 2020

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The human intestines are constantly under the influence of numerous pathological factors: enteropathogenic microorganisms, food antigens, physico‐chemical stress associated with digestion and bacterial metabolism, therefore it must be provided with a system of protection against adverse impact. Recent studies have shown that Paneth cells play a crucial role in maintaining homeostasis of the small intestines. Paneth cells perform many vital functions aimed at maintaining a homeostatic balance between normal microbiota, infectious pathogens and the human body, regulate the qualitative composition and number of intestinal microorganisms, prevent the introduction of potentially pathogenic species, and protect stem cells from damage. Paneth cells take part in adaptive and protective‐inflammatory reactions. Paneth cells maintain dynamic balance between microbial populations, and the macroorganism, preventing the development of intestinal infections and cancer. They play a crucial role in gastrointestinal homeostasis and may be key factors in the etiopathological progression of intestinal diseases.

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Section: Location Morphology and Function Of Paneth Cellsmentioning

confidence: 99%

Section: Location Morphology and Function Of Paneth Cellsmentioning

confidence: 99%

Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer

et al. 2020

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Features of the immunophenotype of cancer stem cells in different stages of colorectal cancer

Майстренко

Chirsky

Ерохина

et al. 2023

Bulletin of the Russian Military Medical Academy

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ABSTRACT. This study examines the immunophenotype characteristics of the stem cell population in colon adenocarcinoma at various stages of the disease and evaluates their impact on the prevalence of the oncological process. The research involved analyzing surgical specimens from 67 patients with histologically confirmed colon adenocarcinoma using microscopic and immunohistochemical techniques. The patients were divided into two groups based on the extent of the neoplastic process. The first group consisted of 32 patients with localized colorectal cancer (T34aN0M0), while the second group included 35 patients with colorectal cancer with synchronous monoorgan liver metastases (T34aN02M1a (hep)).The study assessed the immunophenotype of the tumor and investigated its correlation with the disease stage. The analysis revealed no significant correlation between the proliferative activity index of the immunohistochemical marker Ki67 and the stage of the disease (p = 0.108). However, when comparing the immunophenotype of stem tumor cells in the group of patients with metastatic colorectal cancer, statistically significantly higher levels of expression were observed for the following immunohistochemical markers: ALDH1+ (p = 0.028), ALDH1+Ki67+ (p = 0.0002), and CXCR4+ (p = 0.005). These results indicate a strong association between immunohistochemical markers characterizing the stem cell population and the prevalence of the tumor. Therefore, markers such as ALDH1+, ALDH1+Ki67+, and CXCR4+ can provide valuable insights into the molecular and biological properties of stem tumor cells, aiding in the clinical assessment of the potential aggressiveness of colon adenocarcinoma. The study also found that the median stem cell proliferation index, which considers the proportion of proliferating cells only within the stem cell population and not the entire cell pool, in the group of patients with localized colorectal cancer was 16%. Notably, none of the patients in stage II of the disease had a stem cell proliferation level below 50%, and the stem cell proliferation index ranged from 0% to 50%. Notably, none of the patients in stage II of the disease had a stem cell proliferation level below 50%, and the stem cell proliferation index varied from 0% to 50%. In contrast, the median index of stem cell proliferation in the group of patients with metastatic colorectal cancer was 45.5%, with values ranging from 7% to 100%. The stem cell proliferation index in this group was significantly higher (p = 0.00001) than that in the group with localized tumor processes. Considering the small population of stem tumor cells, determining the index of stem cell proliferation is advisable for a more accurate assessment of their proliferative activity.

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Role of stem cells in large bowel carcinogenesis

Cited by 2 publications

References 44 publications

Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer

Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer

Features of the immunophenotype of cancer stem cells in different stages of colorectal cancer

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