Role of substance P in the pathogenesis of facial pain in rhinosinusitis

Stagnieva, I.V.

doi:10.17116/rosrino201523133-35

Ross. rinol.

2015

DOI: 10.17116/rosrino201523133-35

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Role of substance P in the pathogenesis of facial pain in rhinosinusitis

I.V. Stagnieva¹

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Cited by 3 publications

References 8 publications

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Clinical manifestations of isolated sphenoid sinus disease

Колесников¹,

Бойко²,

Bykova³

2017

Ross. rinol.

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Цель-изучить клинические симптомы изолированного поражения клиновидной пазухи. Материал и методы. Проведен анализ 51 истории болезни пациентов, подвергнутых трансназальному вскрытию клиновидной пазухи за период с января 2014 г. по декабрь 2016 г. Обследование включало сбор анамнеза, эндоскопическое исследование, компьютерную томографию, патогистологическое исследование операционного материала. Результаты. Почти у всех больных (50/51) в клинике превалировала головная боль различной локализации, среди других симптомов отмечались затрудненное носовое дыхание, постназальный затек, глазодвигательные нарушения. По нашим данным, головная боль имела весьма вариабельную локализацию. Чаще всего головная боль локализовалась на стороне поражения по типу гемикрании или имела диффузный характер. Заключение. Головная боль является самым частым симптомом изолированного поражения клиновидной пазухи. Больным с подострой и хронической головной болью всегда следует исследовать состояние околоносовых пазух. Ключевые слова: клиновидная пазуха, изолированное поражение клиновидной пазухи, головная боль.

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Clinical manifestations of isolated sphenoid sinus disease

Колесников¹,

Бойко²,

Bykova³

2017

Ross. rinol.

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The neuro-immunological interactions in pathogenesis of facial pain associated with the diseases of paranasal sinuses

Stagnieva¹,

Volkov²

2017

Ross. rinol.

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Pathogenesis of facial pain in the patients presenting with the diseases of paranasal sinuses is underlain by the nociceptive and neurogenic mechanisms. The role of the immune reactions in the formation of pain is currently a subject of extensive studies. The available data on the interaction between the nervous and immune systems provide a basis for the revision and refinement of the mechanisms of pain experienced by the patients suffering from the diseases of paranasal sinuses. The categorization of facial pain symptoms into somatic and neurogenic ones is justified from the point of view of etiology. These pathogenic mechanisms are inseparable in the clinical manifestations of the diseases of the nose and paranasal sinuses. Regardless of the type of pain, it is associated with inflammation. The activation of pain receptors, transmission and modulation of pain signals are effected by mediators of inflammation. The present review highlights the participation of neurotransmitters and immune cells in the formation of pain. The analysis of the relevant literature has demonstrated that the neuro-immunological mechanisms play an important role in pathogenesis of facial pain even though they remain to be poorly understood. Further studies of the pathogenetic mechanisms behind facial pain in the diseases of the nose and paranasal sinuses are needed for the development of the efficacious diagnostic and treatment methods. Equally important is the elaboration of the clinical models for the elucidation of the role of immune reactivity in the formation of inflammation and facial pain.

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Rhino headache

Бойко¹

2019

Ross. rinol.

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Role of substance P in the pathogenesis of facial pain in rhinosinusitis

Cited by 3 publications

References 8 publications

Clinical manifestations of isolated sphenoid sinus disease

Clinical manifestations of isolated sphenoid sinus disease

The neuro-immunological interactions in pathogenesis of facial pain associated with the diseases of paranasal sinuses

Rhino headache

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