Role of surface activity in the biological actions of ranitidine and famotidine

Pandi, P. V.; Kole, Prashant; Mishra, Pooja; Shanmukha, I; Girish, K. S.; Nagappa, Anantha Naik

doi:10.1016/j.colsurfb.2004.03.006

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…This drug reduces automatic (basal) acid secretion and acid secretion stimulated by food as well as by neural and hormonal influences. Famotidine reduces the permeability of sodium, potassium, calcium, and chloride ions, histamine, and acetylcholine [6].…”

Section: Molecular Mechanism Of Actionmentioning

confidence: 99%

Famotidine for COVID-19

Chrisnanda,

Saputro

2024

Pharm.Rep.

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Famotidine has emerged as a candidate for COVID-19 treatment, with various studies investigating its impact on the virus. These studies have reported encouraging results, suggesting that famotidine might contribute to fighting COVID-19 by potentially blocking histamine release, TMPRSS, and fortifying glycocalyx. Clinical trials aimed at assessing the effectiveness of famotidine in patients with COVID-19 have observed that it contributed to quicker alleviation of symptoms and reduction in inflammation, without compromising the body's immunity against SARS-CoV-2. However, in the case of patients with severe illness, famotidine's use did not significantly enhance survival rates. Although further investigation is necessary, famotidine has shown promise in alleviating symptoms and reducing inflammation in COVID-19 cases.

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Section: Molecular Mechanism Of Actionmentioning

confidence: 99%

Famotidine for COVID-19

Chrisnanda,

Saputro

2024

Pharm.Rep.

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“…The hydraulic permeability was determined separately for Sartorius cellulose acetate micro filtration membrane coated with lecithin alone and cholesterol + lecithin. The procedure described in the earlier publications was adopted for obtaining the hydraulic permeability data For measurement of solute permeability (ω) of the relevant permeants, the equation [22][23][24][25][26][27] was used. ω = [Js/∆π] Jv=o ….. 1Where Js and J V are the solute flux and volume flux per unit area of the membrane, respectively.…”

Section: Fig 1: Ertapenemmentioning

confidence: 99%

Untitled

2014

IJPSR

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INTRODUCTION: Many Pharmacologically active compounds are amphiphilic in nature, which may undergo different types of association, and whose site of action is frequently, the Plasma membrane. In many cases excellent correlation between surface activity of drugs and their biological actions was demonstrated 1-12. Earlier reports show that the wide variety of drugs acts by common mechanism i.e. due to their surface activity, which governs their action 13-20. It has been shown that the surface-active drugs at the site of their action generate liquid membranes, which act as barrier to the transport of essential permeants.

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“…For measurement of solute permeability (ω) of the relevant permeants, the equation [22][23][24][25][26][27] was used.…”

Section: Methodsmentioning

confidence: 99%