Role of Surface Free Energy in Powder Behavior and Tablet Strength

Sun, Changquan Calvin

doi:10.1002/9781119323716.ch4

Cited by 5 publications

(3 citation statements)

References 58 publications

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“…As a result, it has high molecular mobility and plasticity [23]. Due to its physical properties, HPC has been chosen to be made into FDM printable filament as it provides ductility to the filament [24,25]. HPC has been widely used in the pharmaceutical industry as a tablet binder, thickening agent, viscosity increasing agent, and coating agent [23].…”

Section: Introductionmentioning

confidence: 99%

Development and Optimisation of Novel Polymeric Compositions for Sustained Release Theophylline Caplets (PrintCap) via FDM 3D Printing

2019

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This study reports a thorough investigation combining hot-melt extrusion technology (HME) and a low-cost fused deposition modelling (FDM) 3D printer as a continuous fabrication process for a sustained release drug delivery system. The successful implementation of such an approach presented herein allows local hospitals to manufacture their own medical and pharmaceutical products on-site according to their patients' needs. This will help save time from waiting for suitable products to be manufactured off-site or using traditional manufacturing processes. The filaments were produced by optimising various compositions of pharmaceutical-grade polymers, such as hydroxypropyl cellulose (HPC), Eudragit ® (RL PO), and polyethylene glycol (PEG), whereas theophylline was used as a model thermally stable drug. For the purpose of the study, twin-screw hot-melt extrusion (HME) was implemented from the view that it would result in the formation of solid dispersion of drug in the polymeric carrier matrices by means of high shear mixing inside the heated barrel. Four filament compositions consisting of different ratios of polymers were produced and their properties were assessed. The mechanical characterisation of the filaments revealed quite robust properties of the filaments suitable for FDM 3D printing of caplets (PrintCap), whereas the solid-state analyses conducted via DSC and XRD showed amorphous nature of the crystalline drug dispersed in the polymeric matrices. Moreover, the surface analysis conducted via SEM showed a smooth surface of the produced filaments as well as caplets where no drug crystals were visible. The in vitro drug release study showed a sustained release profile over 10 h where about 80% of the drug was released from the printed dosage forms. This indicates that our optimised 3D printed caplets could be suitable for the development of sustained release on-demand drug delivery systems.Polymers 2020, 12, 27 2 of 18 3D printing should be able to produce these medicines, in particular, the solid dosage forms that are adjusted according to the patient's need [3]. The use of 3D printing in producing medicines also allows hospitals and pharmacies to manufacture the medications for patients immediately after consultation. This is particularly beneficial for hospitals in remote areas so that they can supply their own patients with just-in-time medications. Apart from that, 3D printing can be used to produce dosage forms with complex shapes and different release patterns cost-effectively, which can otherwise be relatively expensive and difficult to achieve with traditional manufacturing methods [4][5][6]. It is quite difficult to produce products with high complexity via traditional pharmaceutical processes such as compression and encapsulation, and it is not effective in terms of producing personalised products [7]. With 3D printing, it is possible to fabricate medicines of different shapes, sizes, and structures to tailor the release patterns of the drug [8]. It is also more cost-effective to produce personalise...

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Section: Introductionmentioning

confidence: 99%

Development and Optimisation of Novel Polymeric Compositions for Sustained Release Theophylline Caplets (PrintCap) via FDM 3D Printing

2019

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“…High crystal plasticity, that is, low hardness, corresponds to facile plastic deformation. , The presence of slip planes is necessary for plastic deformation to occur in crystals, where the lower interaction energy and smoother surfaces of slip planes favor more facile slip . Slip planes are commonly identified by visualizing crystal structures, which relies on hydrogen bonding patterns and molecular packing density of layers. , Stacking flat layers or parallel columns with smooth surfaces that interact weakly are crystal packing features that correspond to facile plastic deformation of crystals (Figure ). Crystals with such structures were observed to exhibit good compressibility and tabletability, if bonding strength (collective interaction strength between two adjacent particles over unit bonding area) is comparable among crystals. ,− …”

Section: Introductionmentioning

confidence: 99%

“…17 Slip planes are commonly identified by visualizing crystal structures, which relies on hydrogen bonding patterns and molecular packing density of layers. 18,19 Stacking flat layers or parallel columns with smooth surfaces that interact weakly are crystal packing features that correspond to facile plastic deformation of crystals (Figure 1). Crystals with such structures were observed to exhibit good compressibility and tabletability, if bonding strength (collective interaction strength between two adjacent particles over unit bonding area) is comparable among crystals.…”

Section: ■ Introductionmentioning

confidence: 99%

Identifying Slip Planes in Organic Polymorphs by Combined Energy Framework Calculations and Topology Analysis

Wang

Sun

2018

Crystal Growth & Design

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The relationship between crystal structure and mechanical properties is commonly studied by identifying slip planes through inspecting crystal structures visually, with a focus on the hydrogen bonding interactions. While useful, the visualization method lacks quantitative insight, and the identification of slip planes is subjective. Sometimes, crystal plasticity predicted from structure visualization does not match experimental crystal plasticity and powder tabletability as observed in three polymorphic systems, 6-chloro-2,4-dinitroaniline, indomethacin, and febuxostat. Here, we explored the feasibility of more reliably identifying slip planes by the energy framework approach, combined with analysis of potential slip layer topology. In all three cases, this new approach identified slip planes that are consistent with the observed mechanical plasticity and compaction behavior. Thus, it is superior to the visualization method for crystal structure analysis aimed at identifying active slip planes in organic crystals.

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Surface Free Energy Determination of Powders and Particles with Pharmaceutical Applications: A Critical Review

Etzler

Gardner

2019

Progress in Adhesion and Adhesives

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Role of Surface Free Energy in Powder Behavior and Tablet Strength

Cited by 5 publications

References 58 publications

Development and Optimisation of Novel Polymeric Compositions for Sustained Release Theophylline Caplets (PrintCap) via FDM 3D Printing

Development and Optimisation of Novel Polymeric Compositions for Sustained Release Theophylline Caplets (PrintCap) via FDM 3D Printing

Identifying Slip Planes in Organic Polymorphs by Combined Energy Framework Calculations and Topology Analysis

Surface Free Energy Determination of Powders and Particles with Pharmaceutical Applications: A Critical Review

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