Role of test activity in ethanol-induced disruption of place preference expression in mice

Gremel, Christina M.; Cunningham, Christopher L.

doi:10.1007/s00213-006-0651-5

Cited by 55 publications

(61 citation statements)

References 29 publications

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“…As in previous studies in DBA/2J mice (Gremel and Cunningham, 2007;Cunningham et al, 2006b), ethanol given immediately before the conditioning trial induced increases in locomotor activity (for group means and statistical comparisons, see Table 2). In experiment 1, lesions of the Amy only slightly reduced this ethanol-induced activation.…”

Section: Conditioning Activitysupporting

confidence: 69%

“…Although the differences in activity were relatively minor, subjects with Amy and Acb lesions showed higher levels of activity during the drug-free test. Although level of activation can affect preference (Gremel and Cunningham, 2007), we do not believe that the differences in activity observed in the present studies were sufficient to significantly alter the observed CPP because Acb-lesioned subjects expressed a preference similar to sham subjects. In summary, our data suggest that the Amy and Acb influence the acquisition of ethanol CPP, whereas the Amy modulates CPP expression.…”

Section: The Role Of the Acb And Amy In Locomotor Activitycontrasting

confidence: 59%

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Roles of the Nucleus Accumbens and Amygdala in the Acquisition and Expression of Ethanol-Conditioned Behavior in Mice

Gremel¹,

Cunningham²

2008

J. Neurosci.

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Section: Conditioning Activitysupporting

confidence: 69%

Section: The Role Of the Acb And Amy In Locomotor Activitycontrasting

confidence: 59%

Roles of the Nucleus Accumbens and Amygdala in the Acquisition and Expression of Ethanol-Conditioned Behavior in Mice

Gremel¹,

Cunningham²

2008

J. Neurosci.

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“…It is possible that even a subtle effect of D1/5 activation on locomotion could influence the effects on behavior. In the case of fear extinction and CPP extinction, any increase in activity would impact the expression of freezing or CPP (Gremel and Cunningham, 2007;Groblewski et al, 2009;Lattal and Maughan, 2012), which could be interpreted as an enhancement in extinction when it actually is an artifact of persistent locomotor effects. This is especially true in fear extinction, because activity is so suppressed that even a small effect on locomotion may reveal itself as an effect on freezing.…”

Section: Discussionmentioning

confidence: 99%

Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors

Abraham

Neve

Lattal

2016

Neuropsychopharmacol

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Dopamine is critical for many processes that drive learning and memory, including motivation, prediction error, incentive salience, memory consolidation, and response output. Theories of dopamine's function in these processes have, for the most part, been developed from behavioral approaches that examine learning mechanisms in appetitive tasks. A parallel and growing literature indicates that dopamine signaling is involved in consolidation of memories into stable representations in aversive tasks such as fear conditioning. Relatively little is known about how dopamine may modulate memories that form during extinction, when organisms learn that the relation between previously associated events is severed. We investigated whether fear and reward extinction share common mechanisms that could be enhanced with dopamine D1/5 receptor activation. Pharmacological activation of dopamine D1/5 receptors (with SKF 81297) enhanced extinction of both cued and contextual fear. These effects also occurred in the extinction of cocaine-induced conditioned place preference, suggesting that the observed effects on extinction were not specific to a particular type of procedure (aversive or appetitive). A cAMP/PKA biased D1 agonist (SKF 83959) did not affect fear extinction, whereas a broadly efficacious D1 agonist (SKF 83822) promoted fear extinction. Together, these findings show that dopamine D1/5 receptor activation is a target for the enhancement of fear or reward extinction.

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“…2. The dark and light conditions were studied in separate experiments in order to test mice under identical conditions within each experiment and to avoid comparisons between groups that differed in test session activity due to illumination differences (Gremel & Cunningham, 2007). For mice in the one-compartment groups, the left-right positions of the floor cues were randomly assigned for testing (counterbalanced within conditioning subgroups).…”

Section: Methodsmentioning

confidence: 99%

Effects of combining tactile with visual and spatial cues in conditioned place preference

Cunningham

Zerizef

2014

Pharmacology Biochemistry and Behavior

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Previous research provides little information about variables that determine which elements of contextual cues gain associative control over behavior in the conditioned place preference (CPP) procedure. These studies examined the effect of external visual-spatial cues on CPP when tactile cues served as the conditioned stimuli. DBA/2J mice were trained in the dark (Experiment 1) or light (Experiment 2) using unbiased procedures in which the spatial location of an ethanol-paired tactile cue during training was relevant (two-compartment procedure) or irrelevant (one-compartment procedure). All groups developed CPP, but it was weakest after one-compartment training in the light. In Experiment 3, tactile cues were tested either in the same locations used during training or reversed after two-compartment training in either the dark or light. CPP was unaffected by cue location reversal in the dark, but it was reduced when cue locations changed in the light. Mice in Experiment 4 also received two-compartment training in either the light or dark, but the spatial locations of the drug- and vehicle-paired cues alternated over trials, making external visual-spatial cues irrelevant. In this case, lighting had no effect on CPP. These studies show that cue location does not affect CPP when tactile cue training occurs in the dark. Moreover, they suggest that external visual-spatial cues might enhance CPP when those cues are relevant, but not when an alternating two-compartment procedure is used. The cue reversal effect suggests that relevant external visual-spatial cues acquire associative strength when combined with tactile cues in a two-compartment procedure in the light. Overall, these studies improve our understanding of how external visual-spatial cues interact with tactile cues during drug-induced conditioning, which could have important implications for studies that use CPP to study the neurobiological bases of drug seeking and drug reward.

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Role of test activity in ethanol-induced disruption of place preference expression in mice

Abstract: Disruption of ethanol-CPP observed in DBA/2J mice may be a consequence of high ethanol-induced activity levels. More generally, these studies suggest that competing behaviors can affect expression of a drug-induced CPP independent of affecting the conditioned rewarding effects of the drug.

Cited by 55 publications

References 29 publications

Roles of the Nucleus Accumbens and Amygdala in the Acquisition and Expression of Ethanol-Conditioned Behavior in Mice

Roles of the Nucleus Accumbens and Amygdala in the Acquisition and Expression of Ethanol-Conditioned Behavior in Mice

Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors

Effects of combining tactile with visual and spatial cues in conditioned place preference

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