Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade

Luttman, Jillian Hattaway; Colemon, Ashley; Mayro, Benjamin; Pendergast, Ann Marie

doi:10.1186/s12964-021-00739-6

Cited by 25 publications

(22 citation statements)

References 160 publications

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“…Thus, modulating the oncogenic activity of non-mutated Ras is among the challenges Frontiers in Cell and Developmental Biology frontiersin.org and future strategies for cancer treatment (Sheffels and Kortum, 2021). Something similar is observed with Src (Frame, 2002) and Abl (Greuber et al, 2013;Luttman et al, 2021). For both proteins, it is an increase in expression or catalytic activity, rather than a mutation, that influences cell growth, adhesion strength, and even metastasis.…”

Section: Figurementioning

confidence: 96%

The first embryo, the origin of cancer and animal phylogeny. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation

Cofre

Saalfeld

2023

Front. Cell Dev. Biol.

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The decisive role of Embryology in understanding the evolution of animal forms is founded and deeply rooted in the history of science. It is recognized that the emergence of multicellularity would not have been possible without the formation of the first embryo. We speculate that biophysical phenomena and the surrounding environment of the Ediacaran ocean were instrumental in co-opting a neoplastic functional module (NFM) within the nucleus of the first zygote. Thus, the neoplastic process, understood here as a biological phenomenon with profound embryologic implications, served as the evolutionary engine that favored the formation of the first embryo and cancerous diseases and allowed to coherently create and recreate body shapes in different animal groups during evolution. In this article, we provide a deep reflection on the Physics of the first embryogenesis and its contribution to the exaptation of additional NFM components, such as the extracellular matrix. Knowledge of NFM components, structure, dynamics, and origin advances our understanding of the numerous possibilities and different innovations that embryos have undergone to create animal forms via Neoplasia during evolutionary radiation. The developmental pathways of Neoplasia have their origins in ctenophores and were consolidated in mammals and other apical groups.

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Section: Figurementioning

confidence: 96%

The first embryo, the origin of cancer and animal phylogeny. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation

Cofre

Saalfeld

2023

Front. Cell Dev. Biol.

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“…Of these, SRC, for which we obtained the highest degree node, is known as a key regulator associated with multiple aspects of cancer development, progression, adhesion, and invasion in numerous types of tumor and has previously been highlighted as an attractive target for anticancer therapeutic strategies [18,19]. Among the other identified genes, ALB1, CDKs, CCND1, and JAK2, have been established to play key roles in cell survival, adhesion, and invasion in tumors [20][21][22][23]. Accordingly, these finding would tend to indicate that these key targets could be significantly associated with the anticancer activity of brevilin A.…”

Section: Prediction Of Targets and Screening Of Potential Targetsmentioning

confidence: 99%

Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway

Lee

Kwak

Kim

et al. 2022

Plants

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Brevilin A, which has anticancer activities against a range of cancers, is an abundant constituent of the medicinal herb Centipeda minima (L.) A. Braun & Asch, which has also been reported to have anticancer activity against breast cancer cells. However, the anticancer activities of C. minima and brevilin A against human gastric cancer have yet to be reported. In this study, we aimed to evaluate the cytotoxicity and molecular basis underlying the anticancer activities of extracts of C. minima (CMX) and brevilin A against human gastric cancer (AGS) cells. We deduced the potential targets and mechanisms underlying the anticancer activity of brevilin A based on a network pharmacology approach. CCND1, CDK4, and BCL2L1 were identified as the key anticancer genes targeted by brevilin A. Cytotoxicity analyses revealed that CMX and brevilin A reduced the viability of AGS cells to levels below 50% (9.73 ± 1.29 µg/mL and 54.69 ± 1.38 μM, respectively). Furthermore, Hoechst 33342, annexin V, and propidium iodide staining and western blot analyses revealed that CMX and brevilin A promoted a significant induction of apoptotic cell death by upregulating the expression of cleaved caspase-8 and cleaved caspase-3 and reducing the ratio of Bax to Bcl-2, which is partially consistent with the findings of our network pharmacology analysis. Collectively, our observations indicate that CMX and brevilin A are novel sources of herbal medicine with potential utility as effective agents for the treatment of gastric cancer.

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“…However, there is emerging evidence that shows STAT5 having a wider role in mediating solid tumorigenesis than previously thought. Although STAT5 has not been included in Figure 2 , as it is not yet confirmed to be a potent oncogene in solid tumors, an increased expression level of STAT5 was notably found in lung cancer cells, promoting the survival of cancerous cells via the tyrosine-protein kinase ABL2 and transcriptional coactivator TAZ signaling axis ( 26 , 27 ).…”

Section: Signal Transductionmentioning

confidence: 99%

A review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer

et al. 2022

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Granulocyte colony-stimulating factor receptor (GCSFR) is a critical regulator of granulopoiesis. Studies have shown significant upregulation of GCSFR in a variety of cancers and cell types and have recognized GCSFR as a cytokine receptor capable of influencing both myeloid and non-myeloid immune cells, supporting pro-tumoral actions. This systematic review aims to summarize the available literature examining the mechanisms that control GCSFR signaling, regulation, and surface expression with emphasis on how these mechanisms may be dysregulated in cancer. Experiments with different cancer cell lines from breast cancer, bladder cancer, glioma, and neuroblastoma are used to review the biological function and underlying mechanisms of increased GCSFR expression with emphasis on actions related to tumor proliferation, migration, and metastasis, primarily acting through the JAK/STAT pathway. Evidence is also presented that demonstrates a differential physiological response to aberrant GCSFR signal transduction in different organs. The lifecycle of the receptor is also reviewed to support future work defining how this signaling axis becomes dysregulated in malignancies.

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Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade

Cited by 25 publications

References 160 publications

The first embryo, the origin of cancer and animal phylogeny. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation

The first embryo, the origin of cancer and animal phylogeny. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation

Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway

A review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer

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