Role of the brain neutrophic factor in the genesis of obesity

Abstract

Obesity is directly related to metabolic disorders, and recently, this disorder has been associated with inflammation. Over the past decades, there has been an increase in the number of obesity cases with metabolic syndrome, which belongs to the set of disorders, and includes glucose intolerance and dyslipidemia in addition to obesity. Since obesity is related to the balance of energy consumption, several new factors are currently being considered – metabolic. They are involved in the control of lipid and glucose levels and support cardiovascular homeostasis. The nerve growth factor and brain neurotrophic factor have got into the amount of these factors. The latter plays an important role in the development, regulation and survival of neurons in the hippocampus and other structures related to cognitive functions. Neurotrophic brain factor also regulates energy homeostasis of the body, food behavior, fat oxidation in skeletal muscles and a number of other functions. At present, obesity is also associated with a lower level of neurotrophic factor in the brain. However, it is still an open question whether the introduction of the exogenous factor will help prevent the impact of metabolic syndrome and the progression of obesity. Key words: metabolic syndrome, neurotrophin, neurotrophic brain factor, obesity, triact