Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission

Liu, He; Yan, Weiwei; Lü, Xiaoxing; Zhang, Xiuli; Wei, Jing-Qiu; Wang, Xiaoyu; Wang, Tiao; Wu, Tong; Cao, Jing; Shao, Cuijie; Zhou, Fang; Zhang, Hongxing; Zhang, Peng; Zang, Ting; Lu, Xianfu; Cao, Jun‐Li; Ding, Huiping; Zhang, Licai

doi:10.1016/j.expneurol.2014.07.018

Cited by 18 publications

(19 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous study demonstrated the targeted ablation of the 5-HT-containing neurons limited to the CSF-contacting nucleus. This resulted in the time-dependent enhancement of hyperalgesia and allodynia in persistent pain models along with the complete destruction of the spinal projection of serotonergic axonal output from 5-HT-containing neurons of the CSF-contacting nucleus (Liu et al, 2014). This suggested the specific anatomical and functional characteristics of the CSF-contacting nucleus and the reliability of the targeted ablation experimental technique.…”

Section: Article In Pressmentioning

confidence: 95%

See 1 more Smart Citation

Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress

Wu¹,

Song²,

Liu³

et al. 2015

Neuropeptides

Self Cite

View full text Add to dashboard Cite

Section: Article In Pressmentioning

confidence: 95%

“…injection of CB-HRP or CB + SAP had a similar distribution, as described by previous studies. (Liu et al, 2014) Comparatively, after the i.c.v. injection of CB-SAP, CB-labeled cells of the CSF-contacting nucleus in the brainstem disappeared completely on day 14 ( Fig.…”

Section: Effects Of Targeted Ablation Of the Csf-contacting Nucleus Imentioning

confidence: 99%

Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress

Wu¹,

Song²,

Liu³

et al. 2015

Neuropeptides

Self Cite

View full text Add to dashboard Cite

“…All the drugs were dissolved in an artificial cerebrospinal fluid (ACSF). The dosages of these drugs were based on the results of the preliminary experiments and our previous studies [26][27][28]68]. …”

Section: Drugs and Solutionsmentioning

confidence: 99%

“…CSF-CNs have been found in the hypothalamic nuclei (HPA), where they might be involved in regulating neuroendocrine functions [66]. Moreover, many researchers had observed lots of CSF-CNs in the dorsal raphe nucleus (DRN), a brain region involved in pain modulation and antinociception response [26,58,66].…”

Section: Introductionmentioning

confidence: 99%

“…The special structure and location of CSF-CN indicate that its activity may be associated with the CSF in some unknown way, such as the release or absorption of some bioactivators that is transmitted through non-synaptic signals and subsequently integrated with the signals exchanged from the CSF [68]. Presently, many evidences indicate that the CSF-contacting nucleus might be participating in the transduction and regulation of pain signals [13,26,28,57,60]. It may be also regulating morphine dependence and withdrawal via specific molecular mechanisms, such as 5-HT, substance P, drebrin, ASIC3, CREB and TRPM8 [28,65,69].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of cerebrospinal fluid-contacting nucleus in sodium sensing and sodium appetite

Xing

et al. 2015

Physiology & Behavior

Self Cite

View full text Add to dashboard Cite

mTOR and Erk1/2 Signaling in the Cerebrospinal Fluid-Contacting Nucleus is Involved in Neuropathic Pain

Zhang

et al. 2015

Neurochem Res

View full text Add to dashboard Cite

The cerebrospinal fluid-contacting nucleus (CSF-CN) has been demonstrated to be involved in neuropathic pain, but the underlying molecular mechanisms remain unclear. Previous work has shown that mTOR and ERK1/2 are important signaling pathways regulating neuropathic pain. However, studies on the interactions between these major pathways in neuropathic pain are very rare. Therefore, the purpose of this study is to determine whether mTOR and ERK1/2 exist in the CSF-CN and elucidate their alterations in neuropathic pain, especially, the crosstalk between them. Our results showed that mTOR and ERK1/2 were distributed in the CSF-CN, and their expression levels were increased in chronic constriction injury (CCI)-induced neuropathic pain. Furthermore, the injection of both the mTOR antagonist rapamycin and the ERK1/2 antagonist U0126 into the lateral ventricle of the brain attenuated CCI-induced neuropathic pain. Inhibition of the ERK1/2 pathway had little impact on mTOR signaling, but inhibition of the mTOR pathway significantly increased ERK/2 signaling. The coadministration of rapamycin and U0126 inhibited the rapamycin-induced upregulation of ERK, and had a greater effect on pain behaviors than did the single-drug administrations. These data extend our understanding of the relationship between mTOR and ERK in the supraspinal site and demonstrate that the CSF-CN participates in neuropathic pain via the regulation of mTOR and ERK1/2.

show abstract

Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission

Cited by 18 publications

References 59 publications

Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress

Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress

Role of cerebrospinal fluid-contacting nucleus in sodium sensing and sodium appetite

mTOR and Erk1/2 Signaling in the Cerebrospinal Fluid-Contacting Nucleus is Involved in Neuropathic Pain

Contact Info

Product

Resources

About