Role of the Extracellular Matrix in Muscle Injuries: Histoarchitectural Considerations for Muscle Injuries

Balius, Ramón; Alomar, Xavier; Pedret, Carles; Blasi, Marc; Rodas, Gil; Pruna, Ricard; Amaro, José Peña; Fernández-Jaén, Tomás

doi:10.1177/2325967118795863

Cited by 30 publications

(34 citation statements)

References 7 publications

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“…The absence of an inciting incident might be related to the precise anatomical location of injury and/or severity of tissue disruption, such as whether the injury primarily involves the epimysial layer versus injuries involving the intramuscular aponeuroses. 16,17 Clearly, further research is warranted to explore whether the mechanism of injury is associated with specific injury characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Specific injury characteristics warrant consideration, such as the injury site 14,15 as well as the presence and severity of connective tissue disruption. 13,16 These characteristics can be determined from MRI, hence it is possible that baseline MRI findings may provide some insight regarding differences in recovery time frames following CMSI. 13,15,16 Furthermore, clinical factors at baseline may explain some of the variation in the time taken to return to play (RTP), but the prognostic value of clinical factors for estimating recovery following CMSI requires further investigation.…”

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confidence: 99%

“…13,16 These characteristics can be determined from MRI, hence it is possible that baseline MRI findings may provide some insight regarding differences in recovery time frames following CMSI. 13,15,16 Furthermore, clinical factors at baseline may explain some of the variation in the time taken to return to play (RTP), but the prognostic value of clinical factors for estimating recovery following CMSI requires further investigation. 17 It is likely that intrinsic factors, such as strength, flexibility, and functional capacity, as well as extrinsic factors, such as the stage of the season, the mechanism of injury, and whether it is a first time injury or a re-injury, [17][18][19] play a role in the time that it takes to achieve recovery milestones and RTP following CMSI.…”

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confidence: 99%

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Calf muscle strain injuries in elite Australian Football players: A descriptive epidemiological evaluation

Green

Lin²,

Schache

et al. 2019

Scandinavian Med Sci Sports

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Background: Calf muscle strain injuries (CMSI) show consistent rates of prevalence and re-injury in elite Australian Football players. An epidemiological evaluation is warranted to better understand the clinical presentation and recovery of CMSI. Purpose: First, to describe the epidemiology of CMSI in elite Australian Football players. Second, to determine if recovery following injury is different according to: (a) injury type (index vs re-injury); (b) muscle injured (soleus vs gastrocnemius); and (c) mechanism of injury (running-related activity vs non running-related activity). Study design: Descriptive epidemiological. Methods: Data retrieved from the Soft Tissue injury Registry of the Australian Football League were analyzed. Sixteen clubs submitted data on CMSI from 2014 to 2017. Data included: player characteristics, training and match history at the time of injury, MRI, and the time to reach recovery milestones. Results: One hundred and eighty-four CMSI were included (149 index injuries; 35 re-injuries). Soleus injuries were most prevalent (84.6%). Soleus injuries took 25.4 ± 16.2 days to return to play, whereas gastrocnemius injuries took19.1 ± 14.1 days (P = .097). CMSI sustained during running-related activities took approximately 12 days longer to recover than injuries sustained during non runningrelated activities (P = .001). Compared to index injuries, re-injuries involved older players (P = .03) and significantly more time was taken to run at >90% of maximum speed, return to full training, and return to play (P ≤ .001). Almost all of the observed re-injuries involved soleus (91.4%). Conclusion: Soleus injuries are more prevalent than gastrocnemius injuries in elite Australian Football players. Prognosis appears to be influenced by clinical factors, with CMSI sustained during running-related activities and re-injuries needing more time to recover.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Calf muscle strain injuries in elite Australian Football players: A descriptive epidemiological evaluation

Green

Lin²,

Schache

et al. 2019

Scandinavian Med Sci Sports

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“…Two injuries in exactly the same topographic location and with the same treatment can heal differently depending on the degree of the damage to the connective tissue component (ie, the extent of damage to its extracellular matrix). 5 Injuries of either MCJ-peripheral or central-internalmay have different degrees of histoarchitectural involvement. In this work, we have updated the nomenclature with respect to that in a previous report 5 through broad discussions and have ultimately reached a consensus with more authors.…”

Section: Histological Nomenclature Of Muscle Injuries: Optimizing Thementioning

confidence: 99%

“…19 These 3 structures make up what is known as the myofascial junction (MFJ) between muscle and fascia or the myotendinous junction (MTJ) between muscle and tendon, which mainly has structural function but may also have a mechanical function. 5 The aponeuroses have a direct connective continuum with the MFJ via the perimysium. 14 Histologically, the perimysium joins the aponeurosis at the ends of the muscle fascicles, facilitating the overall functional unity of the skeletal muscle between the MFJ and the tendons themselves ( Figure 1).…”

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A Histoarchitectural Approach to Skeletal Muscle Injury: Searching for a Common Nomenclature

Balius¹,

Blasi²,

Pedret³

et al. 2020

Orthopaedic Journal of Sports Medicine

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In recent years, different classifications for muscle injuries have been proposed based on the topographic location of the injury within the bone-tendon-muscle chain. We hereby propose that in addition to the topographic classification of muscle injuries, a histoarchitectonic (description of the damage to connective tissue structures) definition of the injury be included within the nomenclature. Thus, the nomenclature should focus not only on the macroscopic anatomy but also on the histoarchitectonic features of the injury.

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Polygenic mechanisms underpinning the response to exercise‐induced muscle damage in humans: In vivo and in vitro evidence

Baumert

Cocks

Strauss

et al. 2022

Journal Cellular Physiology

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We investigated whether 20 candidate single nucleotide polymorphisms (SNPs) were associated with in vivo exercise‐induced muscle damage (EIMD), and with an in vitro skeletal muscle stem cell wound healing assay. Sixty‐five young, untrained Caucasian adults performed 120 maximal eccentric knee‐extensions on an isokinetic dynamometer to induce EIMD. Maximal voluntary isometric/isokinetic knee‐extensor torque, knee joint range of motion (ROM), muscle soreness, serum creatine kinase activity and interleukin‐6 concentration were assessed before, directly after and 48 h after EIMD. Muscle stem cells were cultured from vastus lateralis biopsies from a separate cohort (n = 12), and markers of repair were measured in vitro. Participants were genotyped for all 20 SNPs using real‐time PCR. Seven SNPs were associated with the response to EIMD, and these were used to calculate a total genotype score, which enabled participants to be segregated into three polygenic groups: ‘preferential’ (more ‘protective’ alleles), ‘moderate’, and ‘non‐preferential’. The non‐preferential group was consistently weaker than the preferential group (1.93 ± 0.81 vs. 2.73 ± 0.59 N ∙ m/kg; P = 9.51 × 10−4) and demonstrated more muscle soreness (p = 0.011) and a larger decrease in knee joint ROM (p = 0.006) following EIMD. Two TTN‐AS1 SNPs in linkage disequilibrium were associated with in vivo EIMD (rs3731749, p ≤ 0.005) and accelerated muscle stem cell migration into the artificial wound in vitro (rs1001238, p ≤ 0.006). Thus, we have identified a polygenic profile, linked with both muscle weakness and poorer recovery following EIMD. Moreover, we provide evidence for a novel TTN gene‐cell‐skeletal muscle mechanism that may help explain some of the interindividual variability in the response to EIMD.

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Role of the Extracellular Matrix in Muscle Injuries: Histoarchitectural Considerations for Muscle Injuries

Cited by 30 publications

References 7 publications

Calf muscle strain injuries in elite Australian Football players: A descriptive epidemiological evaluation

Calf muscle strain injuries in elite Australian Football players: A descriptive epidemiological evaluation

A Histoarchitectural Approach to Skeletal Muscle Injury: Searching for a Common Nomenclature

Polygenic mechanisms underpinning the response to exercise‐induced muscle damage in humans: In vivo and in vitro evidence

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