Role of the Glucose Tolerance Test as a Predictor of Preeclampsia

Parra-Cordero, Mauro; Sepúlveda‐Martínez, A.; Preisler, Jessica; Pasten, Juan A.; Soto-Chacón, Emiliano; Valdés, Elena; Rencoret, G.

doi:10.1159/000358876

Cited by 10 publications

(9 citation statements)

References 35 publications

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“…Abnormal glucose tolerance has also been implicated as a risk factor for PE (Joffe et al 1998; Parra-Cordero et al 2014). Glucose enters and leaves the red blood cell by passive transport via an intrinsic protein, GLUT1, so that the facilitated diffusion of this species in and out of erythrocytes is in dynamic equilibrium (May 1998; Gabel et al 1997; O’Connell et al 1994; Potts et al 1990; Potts and Kuchel 1992; London and Gabel 1995).…”

Section: Introductionmentioning

confidence: 99%

Determination of glucose exchange rates and permeability of erythrocyte membrane in preeclampsia and subsequent oxidative stress-related protein damage using dynamic-19F-NMR

2017

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The cause of the pregnancy condition preeclampsia (PE) is thought to be endothelial dysfunction caused by oxidative stress. As abnormal glucose tolerance has also been associated with PE, we use a fluorinated-mimic of this metabolite to establish whether any oxidative damage to lipids and proteins in the erythrocyte membrane has increased cell membrane permeability. Data were acquired using 19F Dynamic-NMR (DNMR) to measure exchange of 3-fluoro-3-deoxyglucose (3-FDG) across the membrane of erythrocytes from 10 pregnant women (5 healthy control women, and 5 from women suffering from PE). Magnetisation transfer was measured using the 1D selective inversion and 2D EXSY pulse sequences, over a range of time delays. Integrated intensities from these experiments were used in matrix diagonalisation to estimate the values of the rate constants of exchange and membrane permeability. No significant differences were observed for the rate of exchange of 3-FDG and membrane permeability between healthy pregnant women and those suffering from PE, leading us to conclude that no oxidative damage had occurred at this carrier-protein site in the membrane.Electronic supplementary materialThe online version of this article (doi:10.1007/s10858-017-0092-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Determination of glucose exchange rates and permeability of erythrocyte membrane in preeclampsia and subsequent oxidative stress-related protein damage using dynamic-19F-NMR

2017

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“…The risk factors for preeclampsia and eclampsia are: nulliparity, family history of preeclampsia, multiple gestation, history of diabetes and hypertension, hypertension during pregnancy, rapidly growing hydatidiform mole, mother's age, antiphospholipid syndrome, impaired glucose tolerance, caesarean delivery, race [6,8,[21][22][23] . There is evidence that women who smoke are less likely to develop eclampsia, although the reason is not clear [24] .…”

Section: Risk -Factorsmentioning

confidence: 99%

The link between hypertension and preeclampsia/eclampsia-life-long cardiovascular risk for women

Vakhtangadze¹,

Gakhokidze²,

Хуцишвили³

et al. 2019

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Cardiovascular diseases remain the main cause of death and morbidity in women. Despite the active preventive measures and the reduction in the total number of morbidity and mortality rates, the rate of cardiovascular morbidity remains high in the population, moreover cardiovascular morbidity is increased in women of 35-54 years. Cardiovascular morbidity has several unique characteristics for women; pregnancy, gestational hypertension, preeclampsia/eclampsia are genderspecific risk-factors for further cardiovascular morbidity in women, it's possible to detect these risk-factors in younger age groups and start prevention as early as possible. Arterial hypertension, which is characterized by genetic polymorphism, is an important and a powerful risk factor for development of both acute and chronic cardiovascular diseases; association of arterial hypertension with different metabolic disorders suah as metabolic syndrome, diabetes seems particularly dangerous in pregnancy in terms of peri-pregnancy and lifelong morbidity. Preeclampsia shares some common features with atherogenesis and metabolic changes and atherogenesis and metabolic changes, so presence of hypertension during pregnancy increases the risk of cardiovascular diseases and diabetes later in the life. Is pregnancy revealing or predisposing factor of development cardiovascular diseases is not still clear and to answer these questions more and more studies are required.

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“…The aim of this study is to measure serum levels of calcium, magnesium, uric acid and liver enzymes in pre-eclamptic pregnancy and to compare with those in normal pregnancy. 6…”

Section: Introductionmentioning

confidence: 99%

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2019

MIJOBIO

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Background: Pre-eclampsia is one of the most common causes of maternal and fetal morbidity and mortality. It is a systemic disease that affects about 5-7 % of all pregnancies and is the most common, yet least understood disorder of pregnancy. It is a rapidly progressive condition characterized by high blood pressure, platelet aggregation, swelling of the lower extremities and protein in urine. Sudden weight gain, headaches and changes in vision are important symptoms. Materials and Methods: This case-control study was conducted at Department of Biochemistry, Dr PDM Medical College, Amravati(Maharashtra), India. Data was collected from 70 preeclampsia cases and 70 normal healthy pregnant mothers in the Dept. of Obstetrics and Gynaecology. We have selected 70 cases and 70 controls according to our convenience. Cases are pregnant women with preeclampsia and controls are normal healthy pregnant women. Results: The present study includes 70 cases with pregnancy induced hypertension and 70 controls with normal healthy pregnancy. Mean gestational age showed high significance with Mean ± SD of cases at 36.38 ± 4.19 weeks compared to that of controls at 39.62 ± 1.16 weeks with a p value of < 0.001. Mean gestational age showed high significance with Mean ± SD of cases at 36.38 ± 4.19 weeks compared to that of controls at 39.62 ± 1.16 weeks with a p value of < 0.001. Conclusion: Based on the present study, as serum calcium and magnesium levels are low in preeclamptic mothers and considering the high prevalence of preeclampsia, nutritional conditions of pregnant women seems to be of prime importance. Pregnant women should be educated about nutrition during pregnancy and probable risks of inappropriate diet should be informed.

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Role of the Glucose Tolerance Test as a Predictor of Preeclampsia

Cited by 10 publications

References 35 publications

Determination of glucose exchange rates and permeability of erythrocyte membrane in preeclampsia and subsequent oxidative stress-related protein damage using dynamic-19F-NMR

Determination of glucose exchange rates and permeability of erythrocyte membrane in preeclampsia and subsequent oxidative stress-related protein damage using dynamic-19F-NMR

The link between hypertension and preeclampsia/eclampsia-life-long cardiovascular risk for women

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